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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 11
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Original Article

In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): Substrate activities and effects of inducers

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Pages 1131-1141 | Received 30 Apr 1996, Published online: 27 Aug 2009

References

  • Back D. J., Tjia J., Mönig H., Ohnaus E. E., Park B. K. Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide. European Journal of Clinical Pharmacology 1988; 34: 157–163
  • Berthou F., Guillois B., Riche C., Dreano Y., Jacqz-Aigrain E., Beaune P. H. Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes. Xenobiotica 1992; 22: 671–680
  • Butler M. A., Iwasaki M., Guengerich F. P., Kadlubar F. K. Human cytochrome P450pa (P4501A2), the phenacetin o-deethylase is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proceedings of the National Academy of Sciences, USA 1989; 86: 7696–7700
  • Chhabra R. S., Gram T. E., Fouts J. R. A comparative study of two procedures used in the determination of hepatic microsomal aniline hydroxylation. Toxicology and Applied Pharmacology 1972; 22: 50–58
  • Gee S. J., Green C. E., Tyson C. A. Comparative metabolism of tolbutamide by isolated hepatocytes from rat, rabbit, dog and squirrel monkey. Drug Metabolism and Disposition 1984; 12: 174–178
  • van Gogh H., van Deurzen E. J. M., van Duin C. T. M., van Miert A. S. J. P. A. M. Effect of staphylococcal enterotoxin B-induced diarrhoea on the pharmacokinetics of sulpha-dimidine in the goat. Journal of Veterinary Pharmacology and Therapeutics 1984; 7: 303–305
  • Goubier C., Girard I., Ferry S. High-performance liquid chromatographic assay of debrisoquine and its 4-hydroxy metabolite in human urine. Chromatographia 1991; 32: 523–526
  • TopFit 2–0. Pharmacokinetic and Pharmacodynamic Data Analysis System for the PC, G. Heinzel, R. Woloszcak, P. Thomann. Gustav Fischer, Stuttgart 1993
  • Imai Y., Ito A., Sato R. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. Journal of Biochemistry 1966; 60: 417–428
  • Kato R. Characteristics and differences in the hepatic mixed function oxidases of different species. Pharmacology and Therapeutics 1979; 6: 41–98
  • Klooster van't G. A. E., Horbach G. J. M. J., Natsuhori M., Blaauboer B. J., Noordhoek J., van Miert A. S. J. P. A. M. Hepatic cytochrome P450 induction in goats: effects of model inducers on the metabolism of alkoxyresorufins, testosterone end ethylmorphine, and on apoprotein and mRNA levels. Biochemical Pharmacology 1993; 45: 113–122
  • Klooster van't G. A. E., van Seeventer P. B., Kolker H. J., Smit L. A., Witkamp R. F. High-performance liquid chromatographic method for the routine determination of sulphadimidine, its hydroxy metabolites and N4-acetyl sulphadimidine in body fluids and cell culture media. Journal of Chromatography, Biomedical Applications 1992; 571: 157–168
  • Koop D. R., Crump B. L., Nordblom G. D., Coon M. J. Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proceedings of the National Academy of Sciences, USA 1985; 82: 4065–4069
  • Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
  • Larrey D., Distlerath L. M., Dannan G. A., Wilkinson G. R., Guengerich F. P. Purification and characterization of the rat liver microsomal cytochrome P450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism. Biochemistry 1984; 23: 2787–2795
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265–275
  • Lubet R. A., Mayer R. T., Cameron J. W., Nims R. W., Burke M. D., Wolfe T., Guengerich F. P. Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in the rat. Archives of Biochemistry and Biophysics 1985; 238: 43–48
  • Matsuo Y., Iwahashi K., Ichikawa Y. Debrisoquine 4-monooxygenase and bufuralol 1′-monooxygenase activities in bovine and rabbit tissues. Biochemical Pharmacology 1992; 43: 1911–1919
  • Monshouwer M., Witkamp R. F., Nijmeijer S. M., van Leengoed L. A. M. G., Verheijden J. H. M., van Miert A. S. J. P. A. M. Infection (Actinobacillus pleuropneumoniae) mediated suppression of oxidative hepatic drug metabolism and cytochrome P4503A mRNA levels in pigs. Drug Metabolism and Disposition 1995; 23: 44–47
  • Murray M. Microsomal cytochrome P450-dependent steroid metabolism in male sheep liver. Quantitative importance of 6β-hydroxylation and evidence for the involvement of a P450 from the IIIA subfamily in the pathway. Journal of Steroid Biochemistry and Molecular Biology 1991; 38: 611–619
  • Natsuhori M., Witkamp R. F., Klooster van't G. A. E., van Miert A. S. J. P. A. M. Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme inducing agents phenobarbital, troleandomycin and rifampicin. Xenobiotica 1992; 25: 491–499
  • Relling M. V., Aoyama T., Gonzales F. J., Meyer U. A. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. Journal of Pharmacology and Experimental Therapeutics 1990; 252: 442–447
  • Rutten A. A. J. J. L., Falke H. E., Catsburg J. F., Topp R., Blaauboer B. J., van Holsteyn I., Doorn L., van Leeuwen F. X. R. Interlaboratory comparison of total cytochrome P450 and protein determinations in rat liver microsomes. Archives of Toxicology 1987; 61: 27–33
  • Rutten A. A. J. J. L., Falke H. E., Catsburg J. F., Wortelboer H. M., Blaauboer B. J., Doorn L., van Leeuwen F. X. R., Theelen R., Rietjens I. M. C. M. Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations—standardization of assay conditions. Archives of Toxicology 1992; 66: 237–244
  • Ryan D. E., Koop D. R., Thomas P. E., Coon M. J., Levin W. Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a. Archives of Biochemistry and Biophysics 1986; 246: 663–644
  • Schellens J. H. M., van der Wart J. H. F., Brugman M., Breimer D. D. Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a ‘cocktail’ study design. Journal of Pharmacology and Experimental Therapeutics 1989; 249: 638–645
  • Sharer J. A., Wrighton S. A. Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metabolism and Disposition 1996; 24: 487–494
  • Shimada M. S., Murayama N., Yamazoe Y., Hashimoto H., Ishikawa H., Kato R. Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. Journal of Pharmacology and Experimental Therapeutics 1995; 275: 972–977
  • Smith D. A. Species differences in metabolism and pharmacokinetics: are we close to understanding. Drug Metabolism Reviews 1991; 23: 355–373
  • Teunissen M. W. E., van der Meerburg-Torren J. E., Vermeulen N. P. E., Breimer D. D. Automated HPLC-determination of antipyrine and its main metabolites in plasma, saliva and urine including 4,4′-dihydroxy antipyrine. Journal of Chromatography (Biomedical Applications) 1983; 278: 367–378
  • Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences, USA 1979; 76: 4350–4354
  • Veronese M. E., Mackenzie P. E., Doecke C. J., McManus M. E., Miners J. O., Birkett D. J. Tolbutamide and phenytion hydroxylation by cDNA expressed human liver cytochrome P4502C9. Biochemical and Biophysical Research Communications 1991; 175: 1112–1118
  • Veronese M. E., McManus M. E., Laupattarakasem P., Miners J. O., Birkett D. J. Tolbutamide hydroxylation by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. Drug Metabolism and Disposition 1990; 18: 356–361
  • Weaver R. J., Thompson S., Smith G., Dickins M., Elcombe C. R., Mayer R. T., Burke D. A comparative study of constitutive and induced alkoxyresorufin O-dealkylation and individual cytochrome P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver microsomes. Biochemical Pharmacology 1994; 47: 763–773
  • Witkamp R. F., Klooster van't G. A. E., Nijmeijer S. M., Kolker H. J., Noordhoek J., van Miert A. S. J. P. A. M. Hormonal regulation of oxidative drug metabolism in the dwarf goat. The effects of sex and hormonal treatment on plasma disposition and metabolite formation of sulphadimidine. Journal of Veterinary Pharmacology and Therapeutics 1993a; 16: 55–62
  • Witkamp R. F., Lohuis J. A. C. M., Nijmeijer S. M., Kolker H. J., Noordhoek J., van Miert A. S. J. P. A. M. Species- and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species: cattle, goat, rat and rabbit. Xenobiotica 1992; 21: 1483–1492
  • Witkamp R. F., Nijmeijer S. M., Yun H-I., Kolker H. J., Noordhoek J., van Miert A. S. J. P. A. M. Sulfamethazine as a model compound to assess sex-hormone-dependent cytochrome P-450 activity in rats. Drug Metabolism and Disposition 1993b; 21: 441–446
  • Wolkers J., Jorgensen E. H., Nijmeijer S. M., Witkamp R. F. Time dependent induction of two distinct hepatic cytochrome P4501A catalytic activities at low temperatures in Arctic charr (Salvelinus alpinus) after oral exposure to benzo(a)pyrene. Aquatic Toxicology 1996, (in press)
  • Wortelboek H. M., de Kruif C. A., van Iersel A. A. J., Falke H. E., Noordhoek J., Blaauboer B. J. Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures: the effects of model inducers on apoproteins and biotransformation activities. Biochemical Pharmacology 1991; 42: 381–390
  • Wortelboer H. M., de Kruif C. A., van Iersel A. A. J., Falke H. E., Noordhoek J., Blaauboer B. J. The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers. Biochemical Pharmacology 1990; 40: 2525–2534
  • Zeilmaker W. M., Klooster van't G. A. E., Fink Gremmels-Gehrmann J., van Miert A. S. J. P.-A. M., Horbach G. J. M. J. cDNA and deduced amino acid sequence of a dwarf goat liver cytochrome P450 fragment belonging to the CYP2C gene subfamily. Biochemical and Biophysical Research Communications 1994; 200: 120–125
  • Zweers-Zeilmaker W. M., Maas R. F. M., Horbach G. J., van Miert A. S. J. P. A. M., Witkamp R. F. Cytochrome P4502E in vivo and in vitro in the dwarf goat: Effects of enzyme induction and the applicability of chlorzoxazone as markersubstrate. Journal of Veterinary Pharmacology and Therapeutics 1996; 19: 245–250

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