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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 9
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Original Article

The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations

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Pages 935-946 | Received 02 Mar 1996, Published online: 27 Aug 2009

References

  • Bezek Š., Kukan M., Kállay Z., Trnovec T., ŠKtefek M., Piotrovskiy L. B. Disposition of ethimizol, a xanthine-related nootropic drug, in perfused rat liver and isolated hepatocytes. Drug Metabolism and Disposition: The Biological Fate of Chemicals 1990; 18: 88–95
  • Boobis A. R., Sesardic D., Murray B. P., Edwards R. J., Singleton A. M., Rich K. J., Murray S., de la Torre R., Segura J., Pelkonen O., Pasanen M., Kobayashi S., Zhi-Guang T., Davies D. S. Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors. Xenobiotica 1990; 20: 1139–1161
  • Ewans G. H., Wilkinson G. R., Shand D. G. The disposition of propranolol. V. A dominate role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver. Journal of Pharmacology and Experimental Therapeutics 1973; 186: 447–454
  • Farlow M., Gracon S. I., Hershey L. A., Lewis K. W., Sadowsky C. H., Eolan-Ureno J. A controlled trial of tacrine in Alzheimer's disease. Journal of the American Medical Association 1992; 268: 2523–2529
  • Franklin M. R. The enzymic formation of methylenedioxyphenyl derivative exhibiting an isocyanide-like spectrum with reduced cytochrome P-450 in hepatic microsomes. Xenobiotica 1971; 1: 581–591
  • Hasegawa T., Sadai M., Kuzuya T., Muraoka I., Apichartpichean R., Takagi K., Miyamoto K. The possible mechanism of interaction between xanthines and quinolones. Journal of Pharmacy and Pharmacology 1990; 42: 767–772
  • Hsu R. S., Shutske G. M., Dileo E. M., Chesson S. M., Linville A. R., Allen R. C. Identification of the urinary metabolites of tacrine in the rat. Drug Metabolism and Disposition. The Biological Fate of Chemicals 1990; 18: 779–783
  • Kanaeva I. P., Dedinskii I. R., Skotselyas E. D., Krainev A. G., Guleva I. V., Sevryukova I. F., Koen Y. M., Kuznetsova G. P., Bachmanova G. I., Archakov A. I. Comparative study of monomeric reconstituted and membrane microsomal monooxygenase systems of the rabbit liver. I. Properties of NADPH-cytochrome P450 reductase and cytochrome P450 LM2 (2B4) monomers. Archives of Biochemistry and Biophysics 1992; 298: 395–402
  • Kukan M., Bezek Š., Pool W. F., Woolf T. F. Metabolic disposition of tacrine in primary suspension of rat hepatocytes and in single-pass perfused liver: in vitro/in vivo comparisons. Xenobiotica 1994; 24: 1107–1117
  • Kukan M., Bezek Š., Štefek M., Trnovec T., Ďurišová M., Piotrovskiy L. B. The effect of enzyme induction and inhibition on the disposition of the xanthine-related nootropic drug ethimizol in perfused liver and hepatocytes of rats. Drug Metabolism and Disposition: The Biological Fate of Chemicals 1990; 18: 96–101
  • Kunze K. L., Trager W. F. Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chemical Research in Toxicology 1993; 6: 649–656
  • Madden S., Spaldin V., Hayes R. N., Woolf T. F., Pool W. F., Park B. K. Species variation in the bioactivation of tacrine by hepatic microsomes. Xenobiotica 1995; 25: 103–116
  • Madden S., Woolf T. F., Pool W. F., Park B. K. An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro: studies with human and rat liver microsomes. Biochemical Pharmacology 1993; 46: 13–20
  • Marquis J. K. Pharmacological significance of acetylcholinesterase inhibition by tetrahydroaminoacridine. Biochemical Pharmacology 1990; 40: 1071–1076
  • McNally W. P., Pool W. F., Sinz M. W., DeHart P., Ortwine D. F., Huang C. C., Chang T., Woolf T. F. Distribution of tacrine and metabolites in rat brain and plasma following single and multiple dose regimens: evidence for accumulation of tacrine in brain tissue. Drug metabolism and disposition: the biological fate of chemicals 1996; 24: 628–633
  • Murray M. Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline. Molecular Pharmacology 1992; 42: 931–938
  • Murray M., Wilkinson C. F., Dube C. E. Effects of dihydrosafrole on cytochromes P-450 and drug oxidation in hepatic microsomes from control and induced rats. Toxicology Applications and Pharmacology 1983; 68: 66–76
  • O'Brien J. T., Eagger S., Levy R. Effects of tetrahydroaminoacridine on liver function in patients with Alzheimer's disease. Age and Ageing 1991; 20: 129–131
  • Ormstad K., Låstbom T., Orrenius S. Translocation of amino acids and glutathione studied with the perfused kidney and isolated renal cells. Federation of American Societies of Experimental Biological Letters 1980; 112: 55–59
  • Park B. K., Madden S., Spaldin V., Woolf T. F., Pool W. F. Tacrine transaminitis: potential mechanisms. Alzheimer Disease and Associated Disorders 1993; 8(Suppl. 2)S39–S49
  • Park B. K., Pirmohamed M., Tingle M. D., Madden S., Kitteringham N. R. Bioactivation and bioinactivation of drugs and drug metabolites: relevance to adverse drug reactions. Toxicology In Vitro 1994; 8: 613–621
  • Peters M. M. C. G., Walters D. G., van Ommen B., van Bladeren P. J., Lake B. G. Effect of inducers of cytochrome P-450 on the metabolism of [3-14C]coumarin by rat hepatic microsomes. Xenobiotica 1991; 21: 499–514
  • Pool W. F., Bjorge S. M., Chang T., Woolf T. F. Metabolic disposition of the cognition activator tacrine in man: identification of phenol glucuronides metabolites in urine. ISSX Proceedings Fourth North American Meeting. 1992a, 164, 2
  • Pool W. F., Bjorge S. M., Chang T., Woolf T. F. Effect of 3-methylcholanthrene induction on the disposition of the cognition activator tacrine in rat. ISSX Proceedings Fourth North American Meeting. 1992b, 163, 2
  • Pool W. F., Bjorge S. M., Reily M. D., Chang T., Woolf T. F. Metabolic disposition of the cognition activator tacrine in dog: identification of dihydroxy metabolites including a dihydrodiol. ISSX Proceedings Fourth North American Meeting. 1992c, 162, 2
  • Raval P., Iversen P. L., Bresnick E. Induction of cytochromes P450IA1 and P450IA2 as determined by solution hybridization. Biochemical Pharmacology 1991; 41: 1719–1723
  • Saville B. A., Gray M. R., Tam Y. K. Models of hepatic drug elimination. Drug Metabolism Reviews 1992; 24: 49–88
  • Seglen P. O. Preparation of isolated rat liver cells. Methods Cell Biology 1976; 13: 29–83
  • Sies H. The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems. Methods in Enzymology 1978; 52: 48–59
  • Spaldin V., Madden S., Adams D. A., Edwards R. J., Davies D. S., Park B. K. Determination of human hepatic cytochrome P4501A2 activity in vitro—Use of tacrine as an isoenzyme-specific probe. Drug Metabolism and Disposition: The Biological Fate of Chemicals 1995; 23: 929–934
  • Spaldin V., Madden S., Pool W. F., Woolf T. F., Park B. K. The effect of enzyme inhibition on the metabolic activation of tacrine by human liver microsomes. British Journal Clinical Pharmacology 1994; 38: 15–22
  • Stefek M., Bezek Š. Hepatic uptake and metabolism of pentacaine: a study with microsomes, hepatocytes and perfused livers of rats. Xenobiotica 1985; 15: 805–812
  • Stegman R., Bickel M. H. Dominant role for tissue binding in the first-pass extraction of imipramine by the perfused rat liver. Xenobiotica 1977; 7: 737–746
  • Summers W. K., Majovaki L. V., Marsh A. U., Tachiki K., Kling A. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer's type. New England Journal Medicine 1986; 315: 1241–1245
  • Summers W. K., Tachiki K., Kling A. Tacrine in the treatment of Alzheimer's disease. European Journal of Neurology 1989; 29(Suppl. 3)28–32
  • Truman C. A., Ford J. M., Roberts C. J. C. Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes. Biochemical Pharmacology 1991; 42: 956–959
  • Turcan R. G., Hillbeck D., Hartley T. E., Gilbert P. J., Coe R. A. J., Troke J. A., Vose C. W. Disposition of [14C]velnacrine maleate in rats, dogs, and humans. Drug Metabolism and Disposition: The Biological Fate of Chemicals 1993; 21: 1037–1047
  • Watkins P. B., Zimmerman H. J., Knapp M. J., Gracon S. I., Lewis K. W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. Journal of the American Medical Association 1994; 271: 992–998
  • Waxman D. J., Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochemical Journal 1992; 281: 577–592
  • Woolf T. F., Pool W. F., Bjorge S. M., Chang T., Goel O. P., Purchase C. F. I., Schroeder M. C., Kunze K. L., Trager W. F. Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations: species difference. Drug Metabolism and Disposition: The Biological Rate of Chemicals 1993; 21: 874–882

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