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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 9
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Original Article

Discontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British population

A. Q. Zhang Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
,
S. C. Mitchell Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
&
R. L. Smith Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
Pages 957-961 | Received 18 Mar 1996, Published online: 27 Aug 2009

References

  • Al-Waiz M., Ayesh R., Mitchell S. C., Idle J. R., Smith R. L. A genetic polymorphism of the N-oxidation of trimethylamine in humans. Clinical Pharmacology and Therapeutics 1987b; 42: 588–594
  • Al-Waiz M., Ayesh R., Mitchell S. C., Idle J. R., Smith R. L. Trimethylaminuria; the detection of carriers using a trimethylamine load test. Journal of Inherited Metabolic Disease 1989; 12: 80–85
  • Al-Waiz M., Mitchell S. C., Idle J. R., Smith R. L. The metabolism of 14C-labelled trimethylamine and its N-oxide in man. Xenobiotica 1987a; 17: 551–558
  • Ayesh R., Mitchell S. C., Zhang A. Q., Smith R. L. The fish-odour syndrome: biochemical, familiar and clinical aspects. British Medical Journal 1993; 307: 655–657
  • Cashman J. R. Structural and catalytic properties of the mammalian flavin-coating mono-oxygenase. Chemical Research in Toxicology 1995; 8: 165–181
  • Hadidi H. F., Cholerton S., Atkinson S., Irshaid Y. M., Rawashdeh N. M., Idle J. R. The N-oxidation of trimethylamine in a Jordanian population. British Journal of Clinical Pharmacology 1995; 39: 179–181
  • Inaba T., Olton S. V., Kalow W. Debrisoquine hydroxylation capacity: problems of assessment in two populations. Clinical Pharmacology and Therapeutics 1981; 29: 218–223
  • Jackson P. R., Tucker G. T., Lennard M. S., Woods H. F. Polymorphic drug oxidation: phamacokinetic basis and comparison of experimental indices. British Journal of Clinical Pharmacology 1986; 22: 541–550
  • Mitchell S. C. The fish-odour syndrome. Perspectives in Biology and Medicine 1996; 39(4)223–235
  • Mitchell S. C., Zhang A. Q., Smith R. L. Fish odour syndrome and impaired N-oxidation. Biochemical Society Transactions 1996; 24: 965
  • Willey G. R. Trimethylamine—a Pungent experience. Education in Chemistry 1985; 22: 175–178
  • Zhang A. Q., Mitchell S. C., Ayesh R., Smith R. L. Determination of trimethylamine and related aliphatic amines in human urine by head-space gas chromatography. Journal of Chromatography 1992; 584: 141–145
  • Zhang A. Q., Mitchell S. C., Smith R. L. Fish odour syndrome: verification of carrier detection test. Journal of Inherited Metabolic Disease 1995; 18: 669–674

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