Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 10
21
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Expression of human cytochrome P4501A1 (CYP1A1) in Saccharomyces cerevisiae inhibits cell division

, , , , &
Pages 1013-1023 | Received 22 Apr 1996, Published online: 27 Aug 2009

References

  • Aoyama T., Gonzalez F. J., Gelboin H. V. Human cDNA-expressed cytochrome P450 1A2: mutagen activation and substrate specificity. Molecular Carcinogesis 1989; 2: 192–198
  • Barker C. W., Fagan L. B., Pasco D. S. Interleukin-1β suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes. Journal of Biological Chemistry 1992; 267: 8050–8055
  • Becker D. M., Guarente L. High efficiency transformation of yeast by electroporation. Methods in Enzymology 1991; 194: 182–187
  • Bradford M. M. A rapid and sensitive method for the quantitative of microgram quantities of protein utilising the principle of protein-dye binding. Annals of Biochemistry 1976; 72: 248–254
  • Brent R., Ptashne M. A bacterial protein or a yeast transcriptional terminator can block upstream activation of a yeast gene. Nature 1984; 312: 612–615
  • Burke M. D., Meyer R. T. Ethoxyresorufin: direct fluorometric assay of a microsomal o-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metabolism and Disposition 1974; 2: 583–588
  • Chae Y.-M., Yun C.-H., Geungerich F. P., Kadlubar F. F., El-Bayoumy K. Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene. Cancer Research 1993; 53: 2028–2034
  • Ching M. S., Lennard M. S., Tucker G. T., Woods H. F., Kelly D. E., Kelly S. L. The expression of human cytochrome P4501A1 in the yeast. Sacchromyces cerevisiae. Biochemical Pharmacology 1991; 42: 753–758
  • Crespi C. L., Langenbach R., Rudo K., Chen Y.-T., Davies R. L. Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1 and use of the recombinant cell line in gene mutation assays. Carcinogenesis 1989; 10: 295–301
  • Crespi C. L., Langenbach R., Penman B. W. Human cell lines, derived from AHH-1 TK +/- human lymphoblasts, genetically engineered for expression of cytochromes P450. Toxicology 1993; 82: 89–104
  • Ellis S. W., Ching M. S., Watson P. E., Henderson C. J., Simula A. P., Lennard M. S., Tucker G. T., Woods H. F. Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast. Biochemical Pharmacology 1992; 44: 617–620
  • Eugster H.-P., Probst M., Würgler F. E., Sengstag C. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2: evidence from cDNA expression in. Sacchromyces cerevisiae. Drug Metabolism and Disposition 1993; 21: 43–49
  • Eugster H.-P., Sengstag C., Meyer U. A., Hinnen A., Würgler F. E. Constitutive and inducible expression of human cytochrome P4501A1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies. Biochemical and Biophysical Research Communications 1990; 172: 737–744
  • Fisher C. W., Caudle D. L., Martin-Wixtrom C., Quattrochi L. C., Tukey R. H., Waterman M. R., Estabrook R. W. High-level expression of functional human cytochrome P450 1A2 in. Escherichia coli. FASEB Journal 1992; 6: 759–764
  • Fukuda Y., Ishida N., Noguchi T., Kappas A., Sassa S. Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells. Biochemical and Biophysical Research Communications 1992; 184: 960–965
  • George S. G., Scott J., Ellis S. W. Genetically engineered fish cytochromes P-450 from yeasts for aquatic toxicological studies. Journal of Marine Biotechnology 1995; 3: 220–223
  • Gillette J. R., Brodie B. B., La Du B. N. The oxidation of drugs by liver microsomes: on the role of TNPH and oxygen. Journal of Pharmacology and Experimental Therapeutics 1957; 119: 532–540
  • Glick A. B., Kulkarni A. B., Tennenbaum T., Hennings H., Flanders K. C., O'Reilly M., Sporn M. B., Karlsson S., Yuspa S. H. Loss of expression of transforming growth factor β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proceedings of the National Academy of Science, USA 1993; 90: 6076–6080
  • Gonzalez F. J. The molecular biology of cytochromes P450. Pharmacological Reviews 1989; 40: 243–288
  • Guengerich F. P. Cytochrome P450: advances and prospects. FASEB Journal 1992; 6: 667–668
  • Itoh S., Tagawa S., Sawada M., Kamataki T. High susceptibility to aflatoxin B1 and benzo(a)pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1. Journal of Toxicological Science 1993; 18: 207–210
  • Iwasaki M., Lindberg R. L. P., Juvonen R. O., Negishi M. Site-directed mutagenesis of mouse steroid 7α-hydroxylase (cytochrome P-4507α): role of residue-209 in determining steroidcytochrome P-450 interaction. Biochemical Journal 1993; 291: 569–573
  • Jorgensen E. C. B., Autrup H. Autoregulation of human CYP1A1 gene promoter activity in HepG2 and MCF-7 cells. Carcinogenesis 1996; 17: 435–441
  • Kärenlampi S. O., Eisen H. J., Hankinson O., Nebert D. W. Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12, 13-dibutyrate, or insulin of culture mouse hepatoma cells. Journal of Biological Chemistry 1983; 258: 10378–10383
  • Landers J. P., Bunce N. J. The Ah receptor and the mechanism of dioxin toxicity. Biochemical Journal 1991; 276: 273–287
  • Leaver M.J., Pirrit L., George S. G. Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methyl-cholanthrene and isosafrole. Molecular Marine Biology and Biotechnology 1993; 2: 338–345
  • Lindsay C. K., Chenery R. C., Hawksworth G. M. Primary culture of rat hepatocytes in the presence of dimethyl sulfoxide: a system to investigate the regulation of cytochromes P450 1A. Biochemical Pharmacology 1991; 42: S17–25
  • Lopez Garcia M. P., Dansette P. M., Valadon P., Amar C., Beaune P. H., Guengerich F. P., Mansuy D. Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. European Journal of Biochemistry 1993; 213: 223–232
  • Lu A. Y. H., Levin W., West S., Jacobson M., Ryan D., Kuntzman R., Conney A. H. The role of cytochrome P-450 and P-448 in drug and steroid hydroxylations. Annals of the New York Academy of Science 1973; 212: 156–164
  • Lum P. Y., Walker S., Ioanndies C. Foetal and neonatal development of cytochrome P-450 and cytochrome P-448 catalysed mixed function oxidases in the rat: induction by 3-methylcholanthrene. Toxicology 1985; 35: 307–317
  • McManus M. E., Burgess W. M., Veronese M. E., Huggett A., Quattrochi L. C., Tukey R. H. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Research 1990; 50: 3367–3376
  • Miller J. A. Research in chemical carcinogenesis with Elizabeth Miller—a tail of discovery with our associates. Drug Metabolism Review 1994; 26: 1–36
  • Morray B. P., Edwards R. J., Murray S., Singleton A. M., Davies D. S., Boobis A. R. Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP. Carcinogenesis 1993; 14: 585–592
  • Nebert D. W. Proposed role of drug-metabolising enzymes: regulation of steady state levels of ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Molecular Endocrinology 1991; 5: 1203–1214
  • Nebert D. W., Puga A., Visiliou V. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Annals of the New York Academy of Science 1993; 685: 624–640
  • Nelson D. R., Strobel E. Evolution of cytochrome P-450 proteins. Molecular and Biological Evolution 1987; 4: 572–593
  • Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370–2378
  • Raychaudhuri B., Nebert D. W., Puga A. The murine Cypla-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery. Molecular Endocrinology 1990; 4: 1773–1781
  • Sadek C. M., Allen-Hoffman B. F. Cytochrome P450IA1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics. Journal of Biological Chemistry 1994; 269: 16067–16074
  • Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA 1989
  • Sakaki T., Kominami S., Takemori S., Ohkawa H., Akiyoshi-Shibata M., Yabusaki Y. Kinetic studies on a genetically engineered fused enzyme between rat cytochrome P450 1A1 and yeast NADPH-P450 reductase. Biochemistry 1994; 33: 4933–4939
  • Sesardic D., Boobis A. R., Edwards R. J., Davies D. S. A form of cytochrome P-450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. British Journal of Clinical Pharmacology 1988; 26: 363–372
  • Strathern J. N., Higgins D. R. Recovery of plasmids from yeast into Escherichia coli: shuttle vectors. Methods in Enzymology 1991; 194: 319–329
  • Tassaneeyakul M., Birkett D. J., Veronese M. E., McManus M. E., Tukey R. H., Quattrochi L. C., Gelboin H. V., Miners J. O. Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. Journal of Pharmacology and Experimental Therapeutics 1993; 265: 401–407
  • Vecchini F., Lenoir-Viale M. C., Cathelineau C., Magdalou J., Bernard B. A., Shroot B. Presence of a retinoid responsive element in the promoter region of the human cytochrome P4501A1 gene. Biochemical and Biophysical Research Communications 1994; 201: 1205–1212
  • Vogel C., Döhr O., Abel J. Transforming growth factor-β11 inhibits TCDD-induced cytochrome P4501A1 expression in human lung cancer A549 cells. Archives of Toxicology 1994; 68: 303–307

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.