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Drug and Chemical Toxicology Volume 33, 2010 - Issue 3
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Research Article

A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats

Meng WangCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaCorrespondence[email protected]
,
Bin ShuJiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, China
,
Wen-Xia BaiJiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, China
,
Jin LiuJiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, China
,
Jun YaoJiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, China
,
Wei-Na PanJiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, China
&
Yu-Ying PanJiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, China
 show all
Pages 244-253 | Received 15 Jun 2009, Accepted 31 Aug 2009, Published online: 30 Apr 2010

References

  • Boriskin, Y. S., Leneva, I. A., Pécheur, E. I., Polyak, S. J. (2008). Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem 15:997–1005.
  • Boriskin, Y. S., Pécheur, E. I., Polyak, S. J. (2006). Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection. Virol J 3:56.
  • Brooks, M. J., Sasadeusz, J. J., Tannock, G. A. (2004). Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what’s in the pipeline? Curr Opin Pulm Med 10:197–203.
  • Dippel, D. W., van Breda, E. J., van der Worp H. B., van Gemert H. M., Meijer, R. J., Kappelle, L. J., et al. (2003). PISA Investigators. Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. BMC Cardiovasc Disord 3:2.
  • Dippel, D. W., van Breda E. J., van Gemert H. M., van der Worp H. B., Meijer, R. J., Kappelle, L. J., et al. (2001). Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized, phase II clinical trial. Stroke 32:1607–1612.
  • Fediakina, I. T., Leneva, I. A., Iamnikova, S. S., Livov, D. K., Glushkov, R. G., Shuster, A. M. (2005). Sensitivity of influenza A/H5 viruses isolated from wild birds on the territory of Russia to arbidol in the cultured MDCK cells. Vopr Virusol 50:32–35.
  • Gagarinova, V. M., Ignat’eva, G. S., Sinitskaia, L. V., Ivanova, A. M., Rodina, M. A., Tur’eva, A.V. (1993). The new chemical preparation arbidol: its prophylactic efficacy during influenza epidemics. Zh Mikrobiol Epidemiol Immunobiol 40–43.
  • Gatich, R. Z., Kolobukhina, L. V., Vasil’ev, A. N., Isaeva, E. I., Burtseva, E. I., Orlova, T. G., et al. (2008). Viferon suppositories in the treatment of influenza in adults. Antibiot Khimioter 53:13–17.
  • Glushkov, R. G. (1992). Arbidol, antiviral, immunostimulant, interferon inducer. Drugs Fut 17:1079–1081.
  • Graham, G. G., Scott, K. F., Day, R. O. (2005). Tolerability of paracetamol. Drug Saf 28:227–240.
  • Khamitov, R. A., Loginova, S. Ia., Shchukina, V. N., Borisevich, S. V., Maksimov, V. A., Shuster, A. M. (2008). Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures. Vopr Virusol 53:9–13.
  • Leneva, I. A., Fediakina, I. T., Guskova, T. A., Glushkov, R. G. (2005). Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A. Ter Arkh 77:84–88.
  • Leneva, I. A., Russell, R. J., Boriskin, Y. S., Hay, A. J. (2009). Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol. Antiviral Res 81:132–140.
  • National Research Council. (1996). Guide for the care and use of laboratory animals. Washington, DC: National Academy Press.
  • Obrosova-Serova, N. P., Burtseva, E. I., Nevskii, I. M., Karmanova, R. I., Nazarov, V. I., Pitkenen, A. A., et al. (1991). The protective action of arbidol during a rise in respiratory diseases in 1990. Vopr Virusol 36:380–381.
  • Perrott, D. A., Piira, T., Goodenough, B., Champion, G. D. (2004). Efficacy and safety of acetaminophen vs. ibuprofen for treating children’s pain or fever: a meta-analysis. Arch Pediatr Adolesc Med 158:521–526.
  • Prescott, L. F. (2000). Therapeutic misadventure with paracetamol: fact or fiction? Am J Ther 7:99–114.
  • Semenenko, T. A., Sel’kova, E. P., Gotvianskaia, T. P., Gaidarenko, A. D., Polezhaeva, N. A., Evseeva, L. F., et al. (2005). Characteristics of the immune status in specific and nonspecific prophylaxis of influenza in elderly persons. Zh Mikrobiol Epidemiol Immunobiol 24–28.
  • Shi, L., Xiong, H., He, J., Deng, H., Li, Q., Zhong, Q., et al. (2007). Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus, and adenovirus in vitro and in vivo. Arch Virol 152:1447–1455.
  • Van Breda E. J., van der Worp H. B., van Gemert H. M., Algra, A., Kappelle, L. J., van Gijn J., et al. (2005). PAIS investigators. PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double-blind, clinical trial [ISCRTN 74418480]. BMC Cardiovasc Disord 5:24.
  • Wang, M. Z., Cai, B. Q., Li, L. Y., Lin, J. T., Su, N., Yu, H. X., et al. (2004). Efficacy and safety of arbidol in treatment of naturally acquired influenza. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:289–293.

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