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Research Article

Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats

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Pages 1-7 | Received 11 Dec 2009, Accepted 10 Mar 2010, Published online: 18 Oct 2010

References

  • Brinker, A. M., Ma, J., Lipsky, P. E., Raskin, I. (2007). Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68:732–766.
  • Canter, P. H., Lee, H. S., Ernst, E. (2006). A systematic review of randomized, clinical trials of Tripterygium wilfordii for rheumatoid arthritis. Phytomedicine 13:371–377.
  • Conneely, O. M., Mulac-Jericevic, B., Lydon, J. P. (2003). Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids 68:771–778.
  • Fu, P., Mao, C. S., Gong, Y. (1999). Study on sex hormone levels in Tripterygium wilfordii induced amenorrhea. J Clin Dermatol 28:163–164.
  • Fu, W. J., Yi, J., Zheng, L. J. (2005). The clinical observation on hysteromyoma treated with low-dose Tripterygium wilfordii Hook.f. J Hebei North Univ 22:46–48.
  • Fu, Y. F., Liang, J. N., Shi, Y. P. (1993). The clinical observation on 26 cases of endometriosis treated with Tripterygium wilfordii. Jiangsu J Trad Chin Med 14:36–38.
  • Gao, Y. P., Chen, D. F., Chang, C. (2002). Effect of glycosides of Tripterygium wilfordii on uterus and blood supply of hysteromyoma patients. Shanghai Med J 25:237–239.
  • Gao, Y. P., Chen, D. F., Zhu, J. S. (2003). Effect of glycosides of Tripterygium wilfordii Hook.f. on estrogen and progestors in uterine leiomyoma and muscular tissues. Acta Univ Med Secondae Shanghai 23:47–50.
  • Gao, Y. P., Jin, Z. M., Chen, D. F. (2001). The effect of Tripterygium wilfordii Hook. f. on uterine leiomyoma. Acta Univ Med Secondae Shanghai 21:137–140.
  • Gruenberg, M. L., Steger, R. W., Peluso, J. J. (1983). Follicular development, steroidogenesis, and ovulation within ovaries exposed in vitro to hormone levels which mimic those of the rat estrous cycle. Biol Reprod 29:1265–1275.
  • Gu, W. Z., Brandwein, S. R. (1998). Inhibition of type II collagen-induced arthritis in rats by triptolide. Int J Immunopharm 20:389–400.
  • Guo, J. L., Ren, M. L. (2007). Adverse effect of nonylphenol on the reproductive function of adult female SD rats. J Southeast Univ (Med Sci Edi) 26:287–290.
  • Haruyama, N., Igarashi, K., Saeki, S., Otsuka-Isoya, M., Shinoda, H., Mitani1, H. (2002). Estrous-cycle-dependent variation in orthodontic tooth movement. J Dent Res 81:406–410.
  • Hikim, A. P., Lue, Y. H., Wang, C., Reutrakul, V., Sangsuwan, R., Swerdloff, R. S. (2000). Post-testicular antifertility action of triptolide in the male rat: evidence for severe impairment of cauda epididymal sperm ultrastructure. J Androl 21:431–437.
  • Hoyer, P. (2005). Impact of metals on ovarian function. In: Golub, M. S. (Ed.), Metals, fertility, and reproductive toxicity (pp 155–169). Boca Raton, Florida, USA: Taylor and Francis.
  • Huang, Y. (1995). 50 cases of endometriosis treated with glycosides of Tripterygium wilfordii. Acta Acad Med Nantong 15:70–71.
  • Li, F. Q., Lu, X. Z., Liang, X. B., Zhou, H. F., Xue, B., Liu, X. Y., et al. (2004). Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation. J Neuroimmunol 148:24–31.
  • Li, H. Y., Zhang, W. C., Lin, W., Huang, S. Q., Yan, P. (2001). Study on mechanism of female gonad toxicity induced by carbon disulfide in rats. Chin Occup Med 28:12–14.
  • Liu, J., Jiang, Z. Z., Xiao, J. W., Zhang, Y., Lin, S. S., Duan, W. G., et al. (2009). Effects of triptolide from Tripterygium wilfordii on ERα and p53 expression in two human breast cancer cell lines. Phytomedicine 16:1006–1013.
  • Lue, Y., Sinha Hikim, A. P., Wang, C., Leung, A., Baravarian, S., Reutrakul, V., et al. (1998). Triptolide: a potential male contraceptive. J Androl 19:479–486.
  • Luo, J. H., Hu, Z. H. (2002). Tripterygium wilfordii treating the postoperation cases of endometriosis. J Clin Mil Surg 30:41–42.
  • Madhabananda, S., Frank, W. (1999). Differential expression of estrogen receptor-b and estrogen receptor-a in the rat ovary. Endocrine 2:963–971.
  • Matlin, S. A., Belenguer, A., Stacey, V. E., Qian, S. Z., Xu, Y., Zhang, J. W., et al. (1993). Male antifertility compounds from Tripterygium wilfordii Hook f. Contraception 47:387–400.
  • McDonnell, D. P., Norris, J. D. (2002). Connections and regulation of the human estrogen receptor. Science 296:1642–1644.
  • Michel, F., Antanio, T., Paula, E. Z., Raymond, L. V. W. (1969). Effect of antibodies to 17b-estradiol and progesterone on the estrous cycle of the rat. Endocrine 85:1070–1078.
  • Natraj, U., Richards, J. S. (1993). Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles. Endocrine 133:761–769.
  • Ni, B., Jiang, Z., Huang, X., Xu, F., Zhang, R., Zhang, Z., et al. (2008). Male reproductive toxicity and toxicokinetics of triptolide in rats. Arzneimittelforschung 58:673–680.
  • Qian, S. Z., Xu, Y., Zhang, J. W. (1995). Recent progress in research on Tripterygium: a male antifertility plant. Contraception 51:121–129.
  • Qian, S. Z., Zhong, C. Q., Xu, Y. (1986). Effect of Tripterygium wilfordii on the fertility of rats. Contraception 33:105–110.
  • Shamon, L. A., Pezzuto, J. M., Graves, J. M., Mehta, R. R., Wangcharoentrakul, S., Sangsuwan, R., et al. (1997). Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii. Cancer Lett 112:113–117.
  • Shi, J. H., Wang, M. J., Liu, X. D. (2003). High gonadotropin and amenorrhea induced by Tripterygium wilfordii in two patients. Chin J New Drugs Clin Rem 22:635–636.
  • Smith, M. S., Freeman, M. E., Neill, J. D. (1975). The control of progesterone secretion during estrous cycle and early pseudopregnancy in the rat: prolaction, gonadotropin, and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrine 96:219–226.
  • Smith, E. L., Hill, R. L., Leliman, I. R., Lefkocoitz, R. J., Handler, P., White, A. (1987). Principles of biochemistry; mammalian biochemistry, 7th ed. New York: McGraw-Hill.
  • Sun, X., Zhang, S. M., Tian, C. H., Yan, L., Wang, L. M., Li, S. L. (2001). Safety of Tripterygium wilfordii. Chin J New Drugs 10:539–543.
  • Thakur, S. C., Thakur, S. S., Chaube, S. K., Singh, S. P. (2005). An etheral extract of Kamala (Mallotus philippinensis (Moll.Arg) Lam) seed induce adverse effects on reproductive parameters of female rats. Reprod Toxicol 20:149–156.
  • Yang, S. X., Gao, H. L., Xie, S. S., Zhang, W. R., Long, Z. Z. (1992). Immunosuppression of triptolide and its effect on skin allograft survival. Int J Immunopharm 14:963–969.
  • Zhang, S. Y. (1995). 5 cases report of Tripterygium wilfordii inducing premature ovarian failure. Sichuan Med 16:19–29.
  • Zhang, Q. X., Song, M., Yang, Y. X. (2004). 1 case of dysfunctional uterine bleeding indued by Tripterygium wilfordii. Chin J Pharmacoepidemiol 13:83–85.
  • Zhao, L. X. (2003). 64 cases of hysteromyoma treated with Tripterygium wilfordii Hook.f. Chin J Integr Trad West Med 23:787–788.

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