An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline

References

• Akgun, A., Kalkan, S., Demir, A., Aksay Hocaoglu, N., Gidener, S., Tuncok, Y. (2009). Does adenosine A1 receptor stimulation causes QRS prolongation by blocking beta adrenergic receptors in amitriptyline poisoning? Toxicol Lett 186:130–138.
   PubMed Web of Science ®Google Scholar
• Akgun, A., Kalkan, S., Hocaoglu, N., Gidener, S., Tuncok, Y. (2008). Effects of adenosine receptor antagonists on amitriptyline-induced QRS prolongation in isolated rat hearts. Clin Toxicol 46:677–685.
   Web of Science ®Google Scholar
• Baldessarini, R. J. (2005). Drug therapy of depression and anxiety disorders. In: Brunton, L. L., Lazo, J. S., Parker, K. (Ed.), Goodman & Gilman’s, the pharmacological basis of therapeutics (pp 429–459). New York: McGraw-Hill.
   Google Scholar
• Barry, J. D., Durkovich, D. W., Williams, S. R. (2006). Vasopressin treatment for cyclic antidepressant overdose. J Emerg Med 3:65–68.
   Google Scholar
• Belardinelli, L., Shryock, J. C., Snowdy, S., Zhang, Y., Monopoli, A., Lozza, G., et al. (1998). The A2a adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284:1066–1073.
   PubMed Web of Science ®Google Scholar
• Benowitz, N. L. (2004). Antidepressants, tricyclic. In: Olson, K. R. (Ed.)., Poisoning and drug overdose (pp 90–93). Stamford, Connecticut, USA: Appleton and Lange.
   Google Scholar
• Bianchi, C. P. (1968). Pharmacological actions on excitation-contraction coupling in striated muscle. Fed Proc 27:126–131.
   PubMedGoogle Scholar
• Bryan, P. T., Marshall, J. M. (1999). Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. J Physiol 514:151–162.
   PubMed Web of Science ®Google Scholar
• Downes, M. A. (2003). Glucagon. Emerg Med (Fremantle) 15:480–485.
   PubMedGoogle Scholar
• Fakioglu, H., Gelvez, J., Torbati, D., Glover, M. L., Olarte, J. L., Camacho, M. T., et al. (2004). Aminophylline therapy during endotoxemia in anesthetized spontaneously breathing rats. Pharmacol Res 49:45–50.
   PubMed Web of Science ®Google Scholar
• Heard, K., Dart, R. C., Bogdan, G., O’Malley, G. F., Burkhart, K. K., Donovan, J. W., Ward, S. B. (2006). A preliminary study of tricyclic antidepressant (TCA) ovine FAB for TCA toxicity. Clin Toxicol (Phila) 44:275–281.
   PubMed Web of Science ®Google Scholar
• Hinschen, A. K., Rose’Meyer, R. B., Headrick, J. P. (2003). Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. J Cardiovasc Pharmacol 41:73–80.
   PubMed Web of Science ®Google Scholar
• Kalkan, S., Tuncok, Y., Guven, H. (1998). Poisoning reported to Drug and Poison Information Center, in Izmir [Turkish]. J Dokuz Eylul Univ School Med 12:275–283.
   Google Scholar
• Kalkan, S., Aygoren, O., Akgun, A., Gidener, S., Guven, H., Tuncok,  Y. (2004). Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats. J Toxicol Clin Toxicol 42:945–954.
   PubMed Web of Science ®Google Scholar
• Kalkan, S., Hocaoglu, N., Akgun, A., Gidener, S., Tuncok, Y. (2007). Effects of the adenosine receptor antagonists on amitriptyline-induced vasodilation in rat isolated aorta. J Toxicol Clin Toxicol 45:600–604.
   Google Scholar
• Kaplan, Y. C., Hocaoglu, N., Oransay, K., Kalkan, S., Tuncok, Y. (2008). Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats. Hum Exp Toxicol 27:321–325.
   PubMed Web of Science ®Google Scholar
• Klasco, R. K. (Ed.). POISINDEX® System (vol 140: expires 06/2009). Greenwood Village, Colorado, USA: Thomson Reuters.
   Google Scholar
• Lerman, B. B., Belardinelli, L. (1991). Cardiac electrophysiology of adenosine. Basic and clinical concepts. Circulation 83:1499–1509.
   PubMed Web of Science ®Google Scholar
• Liebelt, E. L., Francis, P. D. (2002). Cyclic antidepressants. In: Goldfrank, L. R., Flomenbaum, N. M., Lewin, N. A., Howland,  M. A., Hoffman, R. S., Nelson, L. S. (Eds.)., Goldfrank’s toxicology emergencies (pp 847–864). New York: McGraw-Hill.
   Google Scholar
• Lynge, J., Hellsten, Y. (2000). Distribution of adenosine A1, A2a, and A2b receptors in human skeletal muscle. Acta Physiol Scand 169:283–290.
   PubMedGoogle Scholar
• McCabe, J. L., Menegazzi, J. J., Cobaugh, D. J., Auble, T. E. (1994). Recovery from severe cyclic antidepressant overdose with hypertonic saline/dextran in a swine model. Acad Emerg Med 1:111–115.
   PubMedGoogle Scholar
• Nattel, S., Mittleman, M. (1984). Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity in dogs. J Pharmacol Exp Ther 231:430–435.
   PubMed Web of Science ®Google Scholar
• Ngai, A. C., Coyne, E. F., Meno, J. R., West, G. A., Winn, H. R. (2001). Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles. Am J Physiol 280:2329–2335.
   Google Scholar
• Olsson, R. A., Pearson, J. D. (1990). Cardiovascular purinoceptors. Physiol Rev 70:761–845.
   PubMed Web of Science ®Google Scholar
• Pentel, P. R, Wananukul, W., Scarlett, W., Keyler, D. E. (1996). Nitric oxide contributes to desipramine-induced hypotension in rats. Hum Exp Toxicol 15:320–328.
   PubMed Web of Science ®Google Scholar
• Persson, C. G., Erjefält, I., Andersson, K. E. (1983). Positive inotropic and chronotropic effects and coronary vasodilation in vitro by two antiasthmatic xanthines with different abilities to antagonize adenosine. J Cardiovasc Pharmacol 5:778–785.
   PubMed Web of Science ®Google Scholar
• Rongen, G. A., Brooks, S. C., Pollard, M. J., Ando, S., Dajani, H. R., Notarius, C. F., et al. (1999). Effect of adenosine on heart rate variability in humans. Clin Sci 96:597–604.
   PubMed Web of Science ®Google Scholar
• Sensky, P. R., Olczak, S. A. (1999). High dose intravenous glucagon in severe tricyclic poisoning. Postgrad Med J 75:611–612.
   PubMed Web of Science ®Google Scholar
• Sharp, P. E., La Regina, M. C. (1998). Important biological features. In: Suchow, M. A. (Ed.), The laboratory rat (pp 1–15). Boca Raton, Florida, USA: CRC Press.
   Google Scholar
• Shryock, J. C., Belardinelli, L. (1997). Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am J Cardiol 79:2–10.
   PubMed Web of Science ®Google Scholar
• Stork, C. M., Howland, M. A. (2001). Theophylline. In: Ford, M. D., Delaney, K. A., Ling, L. J., Erickson, T. (Eds.), Clinical toxicology, 1st ed. (pp 412–417). Philadelphia, Pennsylvania, USA: W.B. Saunders Company.
   Google Scholar
• Thanacoody, H. K., Thomas, S. H. (2005). Tricyclic antidepressant poisoning: cardiovascular toxicity. Toxicol Rev 24:205–214.
   PubMedGoogle Scholar
• Tuncok, Y., Kalkan, S., Murat, N., Arkan, F., Guven, H., Aygoren,  O., et al. (2002). The effect of the nitric oxide synthesis inhibitor, L-NAME, on amitriptyline-induced hypotension in rats. J Toxicol Clin Toxicol 40:121–127.
   PubMed Web of Science ®Google Scholar
• Vassallo, R., Lipsky, J. J. (1998). Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice. Mayo Clin Proc 73:346–354.
   PubMed Web of Science ®Google Scholar
• Waring, W. S., Good, A. M., Bateman, D. N. (2007). Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit. Clin Toxicol 45:45–50.
   Web of Science ®Google Scholar
• Weinberger, M., Hendeles, L. (1996). Theophylline in asthma. NEJM 334:1380–1388.
   PubMed Web of Science ®Google Scholar
• Whyte, I. M., Dawson, A. H., Buckley, N. A. (2003). Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. QJM 96:369–374.
   PubMed Web of Science ®Google Scholar