86
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Methylphenidate lacks genotoxic effects in mouse peripheral blood erythrocytes

, , , , &
Pages 294-299 | Received 23 Jul 2010, Accepted 20 Sep 2010, Published online: 07 Jun 2011

References

  • American Academy of Child and Adolescent Psychiatry. (2002). Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 41:26S–48S
  • Andreazza, A. C., Frey, B. N., Valvassori, S. S., Zanotto, C., Gomes, K. M., Comim, C. M., et al. (2007). DNA damage in rats after treatment with methylphenidate. Prog Neuropsychopharmacol Biol Psychiatry 31:1282–1288.
  • Biederman, J., Faraone, S. V. (2005). Attention-deficit hyperactivity disorder. Lancet 366:237–248.
  • Bonassi, S., Znaor, A., Norppa, H., Hagmar, L. (2004). Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective. Cytogenet Genome Res 104:376–382.
  • Bonassi, S., Znaor, A., Ceppi, M., Lando, C., Chang, W. P., Holland, N., et al. (2007). An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28:625–631.
  • Cammerer, Z., Elhajouji, A., Kirsch-Volders, M., Suter, W. (2007). Comparison of the peripheral blood micronucleus test using flow cytometry in rat and mouse exposed to aneugens after single-dose applications. Mutagenesis 22:129–134.
  • Devilbiss, D. M., Berridge, C. W. (2008). Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsiveness. Biol Psychiatry 64:626–635.
  • El-Zein, R. A., Abdel-Rahman, S. Z., Hay, M. J., Lopez, M. S., Bondy, M. L., Morris, D. L., et al. (2005). Cytogenetic effects in children treated with methylphenidate. Cancer Lett 23:284–291.
  • Faraone, S. V., Sergeant, J., Gillberg, C., Biederman, J. (2003). The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2:104–113.
  • Gray, J. D., Punsoni, M., Tabori, N. E., Melton, J. T., Fanslow, V., Ward, M. J., et al. (2007). Methylphenidate administration to juvenile rats alters brain areas involved in cognition, motivated behaviors, appetite, and stress. J Neurosci 27:7196–7207.
  • Greenhill, L. L., Pliszka, S., Dulcan, M. K., Bernet, W., Arnold, V., Beitchman, J., et al. (2001). Summary of the practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 40:1352–1355.
  • Hagmar, L., Stromberg, U., Bonassi, S., Hansteen, I. L., Knudsen, L. E., Lindholm, C., et al. (2004). Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts. Cancer Res 64:2258–2263.
  • Kimko, H. C., Cross, J. T., Abernethy, D. R. (1999). Pharmacokinetics and clinical effectiveness of methylphenidate. Clin Pharmacokinet 37:457–470.
  • Klein-Schwartz, W. (2002). Abuse and toxicity of methylphenidate. Curr Opin Pediatr 14:219–223.
  • Klein-Schwartz, W. (2003). Pediatric methylphenidate exposures: 7-year experience of poison centers in the United States. Clin Pediatr (Phila) 42:159–164.
  • Manjanatha, M. G., Shelton, S. D., Dobrovolsky, V. N., Shaddock, J. G., McGarrity, LG, Doerge, D. R., et al. (2008). Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice. Environ Mol Mutagen 49:585–593.
  • Manjanatha, M. G., Shelton, S. D., Dobrovolsky, V. N., Shaddock, J. G., McGarrity, L. G., Twaddle, N. W., et al. (2009). Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks. Mutat Res 680(1–2):43–48.
  • Mannuzza, S., Klein, R. G., Bessler, A., Malloy, P., Hynes, M. E. (1997). Educational and occupational outcome of hyperactive boys grown up. J Am Acad Child Adolesc Psychiatry 36:1222–1227.
  • Mannuzza, S., Klein, R. G., Bessler, A., Malloy, P., LaPadula, M. (1998). Adult psychiatric status of hyperactive boys grown up. Am J Psychiatry 155:493–498.
  • Ponsa, I., Ramos-Quiroga, J. A., Ribasés, M., Bosch, R., Bielsa, A., Ordeig, M. T., et al. (2009). Absence of cytogenetic effects in children and adults with attention-deficit/hyperactivity disorder treated with methylphenidate. Mutat Res 666(1–2):44–49.
  • Safer, D. J. (2000). Are stimulants overprescribed for youths with ADHD? Ann Clin Psychiatry 12:55–62.
  • Sunohara, G. A., Malone, M. A., Rovet, J., Humphries, T., Roberts, W., Taylor, M. J. (1999). Effect of methylphenidate on attention in children with attention deficit hyperactivity disorder (ADHD): ERP evidence. Neuropsychopharmacology 21:218–228.
  • Suter, W., Martus, H. J., Elhajouji, A. (2006). Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. Mutat Res 607:153–159.
  • Swanson, J. M., Gupta, S., Guinta, D., Flynn, D., Agler, D., Lerner, M., et al. (1999). Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children. Clin Pharmacol Ther 66:295–305.
  • Swanson, J. M., Volkow, N. D. (2002). Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD. Behav Brain Res 130:73–78.
  • Teicher, M. H., Polcari, A., Foley, M., Valente, E., McGreenery, C. E., Chang, W-W., et al. (2006). Methylphenidate blood levels and therapeutic response in children with attention-deficit hyperactivity disorder I. Effects of different dosing regimens. J Child Adolesc Psychopharmacol 16:416–431.
  • Teo, S. K., San, R. H., Wagner, V. O., Gudi, R., Stirling, D. I., Thomas, S. D., et al. (2003). Methylphenidate is non-genotoxic in in vitro and in vivo assays. Mutat Res 537:67–79.
  • Tucker, J. D., Suter, W., Petibone, D. M., Thomas, R. A., Bailey, N. L., Zhou, Y., et al. (2009). Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder. Mutat Res 677(1–2):53–58.
  • Volkow, N. D., Wang, G. J., Fowler, J. S., Ding, Y. S. (2005). Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1410–1415.
  • Walitza, S., Werner, B., Romanos, M., Warnke, A., Gerlach, M., Stopper, H. (2007). Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder? Environ Health Perspect 115:936–940.
  • Walitza, S., Kampf, K., Artamonov, N., Romanos, M., Gnana Oli, R., Wirth, S., et al. (2009). No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy. Toxicol Lett 184:38–43.
  • Wargin, W., Patrick, K., Kilts, C., Gualtieri, C. T., Ellington, K., Mueller, R. A., et al. (1983). Pharmacokinetics of methylphenidate in man, rat, and monkey. J Pharmacol Exp Ther 226:382–386.
  • Witt, K. L., Shelby, M. D., Itchon-Ramos, N., Faircloth, M., Kissling, G. E., et al. (2008). Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. J Am Acad Child Adolesc Psychiatry 47:1375–1383.
  • Witt, K. L., Malarkey, D. E., Hobbs, C. A., Davis, J. P., Kissling, G. E., Caspary, W., et al. (2010). No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen 51:80–88.
  • Zito, J. M., Safer, D. J., dos Reis, S., Gardner, J. F., Boles, M., Lynch, F. (2000). Trends in the prescribing of psychotropic medications to preschoolers. JAMA 283:1025–1030.
  • Zuddas, A., Ancilletta, B., Muglia, P., Cianchetti, C. (2000). Attention-deficit/hyperactivity disorder, a neuropsychiatric disorder with childhood onset. Eur J Paediatr Neurol 4:53–62.
  • Zúñiga-González, G., Gómez-Meda, B. C., Zamora-Perez, A., Ramos-Ibarra, M. L., Batista-González, C. M., Espinoza-Jiménez, S., et al. (2003). Induction of micronuclei in proestrus vaginal cells from colchicine- and cyclophosphamide-treated rats. Environ Mol Mutagen 42:306–310.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.