Chronic treatment of haloperidol induces pathological changes in striatal neurons of guinea pigs: a light and electron microscopical study

References

• Altunkaynak, B. Z., Ozbek, E., Aydin, N., Aydin, M. D., Altunkaynak, M. E., Vuraler, O., et al. (2011). Effects of haloperidol on striatal neurons: relation to neuronal loss (a stereological study). Folia Neuropathol 49:21–27.
   PubMed Web of Science ®Google Scholar
• Andreassen, O. A., Aamo, T. O., Jùrgensen, H. A. (1996). Inhibition by memantine of the development of persistent oral dyskinesias induced by long-term haloperidol treatment of rats. Br J Pharmacol 119:751–757.
   PubMed Web of Science ®Google Scholar
• Andreassen, O. A., Ferrante, R. J., Aamo, T. O., Beal, M. F., Jørgensen, H. A. (2003). Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of rats. Neuroscience 122:717–725.
   PubMed Web of Science ®Google Scholar
• Bardgett, M. E., Humphrey, W. M., Csemansky, J. G. (2002). The effects of excitotoxic hippocampal lesions in rats on risperidone- and olanzapine-induced locomotor suppression. Neuropsychopharmacology 27:930–938.
   PubMed Web of Science ®Google Scholar
• Behl, C., Lezoulac’h, F., Widmann, M., Rupprecht, R, Holsboer, F. (1996). Oxidative stressresistant cells are protected against haloperidol toxicity. Brain Res 717:193–195.
   PubMed Web of Science ®Google Scholar
• Cesario, V. (2008). Acute extrapyramidal syndrome and neuroleptical malignant syndrome. A case report. [Article in Italian]. Recenti Prog Med 99:146–148.
   PubMedGoogle Scholar
• Crawford, K. W., Bowen, W. D. (2002). Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 62:313–322.
   PubMed Web of Science ®Google Scholar
• Geptiremen, A., Aydin, N., Halici, Z., Sahin, O., Unal, B., Aydin, M. D., et al. (2004). Chronic treatment of haloperidol causes vasoconstriction on basilar arteries of rats, dose dependently. Pharmacol Res 50:569–574.
   PubMed Web of Science ®Google Scholar
• Kane, J. M. (1995). Tardive dyskinesia: epidemiology and clinical presentation. In: Bloom, F. E., Kupfer, D. J. (Eds.), Psychopharmacology: the fourth generation of progress (vol. 39, pp. 1485–1495). New York: Raven Press.
   Google Scholar
• Kondo, Y., Iwatsubo, K. (1980). Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum. Brain Res 181:237–240.
   PubMed Web of Science ®Google Scholar
• Lacasse, H., Perreault, M. M., Williamson, D. R. (2006). Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients. Ann Pharmacother 40:1966–1973.
   PubMed Web of Science ®Google Scholar
• Lezoualc’h, F., Rupprecht, R., Holsboer, F., Behl, C. (1996). Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol. Brain Res 738:176–179.
   PubMed Web of Science ®Google Scholar
• Martins, M. R., Petronilho, F. C., Gomes, K. M., Dal-Pizzol, F., Streck, E. L., Quevedo, J. (2008). Antipsychotic-induced oxidative stress in rat brain. Neurotox Res 13:63–69.
   PubMed Web of Science ®Google Scholar
• Merchant, K. M., Miller, M. A., Ashleigh, E. A., Dorsa, D. M. (1991). Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain. Brain Res 540:311–314.
   PubMed Web of Science ®Google Scholar
• Mitchell, I. J., Cooper, A. C., Griffiths, M. R., Cooper, A. J. (2002). Acute administration of haloperidol induces apoptosis of neurones in the striatum and substantia nigra in the rat. Neuroscience 109:89–99.
   PubMed Web of Science ®Google Scholar
• Ozbek, E, Altunkaynak, BZ, Aydin, MD, Aydin, N, Vuraler, O, Unal, B. (2010). Haloperidol-Induced Neuronal Damage in Guinea Pig Hippocampus: A Microscopic Study. J. Neurol Sci [Turk] 27:438–445.
   Web of Science ®Google Scholar
• Pillai, A., Dhandapani, K. M., Pillai, B. A., Terry, A. V., Jr., Mahadik, S. P. (2008). Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Neuropsychopharmacology 33:1942–1951.
   PubMed Web of Science ®Google Scholar
• Post, A., Rucker, M., Ohl, F., Uhr, M., Holsboer, F., Almeida, O. F., et al. (2002). Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity. Neuropsychopharmacology 26:397–407.
   PubMed Web of Science ®Google Scholar
• Seitz, D. P., Gill, S. S. (2009). Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: case reports and a review of the literature. Psychosomatics 50:8–15.
   PubMed Web of Science ®Google Scholar
• Shivakumar, B. R., Ravindranath, V. (1992). Oxidative stress induced by administration of the neuroleptic drug haloperidol is attenuated by higher doses of haloperidol. Brain Res 595:256–262.
   PubMed Web of Science ®Google Scholar
• Skoblenick, K. J., Castellano, J. M., Rogoza, R. M., Dyck, B. A., Thomas, N., Gabriele, J. P., et al. (2006). Translocation of AIF in the human and rat striatum following protracted haloperidol, but not clozapine treatment. Apoptosis 11:663–672.
   PubMed Web of Science ®Google Scholar
• Tsai, G., Goff, D. C., Chang, R. W., Flood, J., Baer, L., Coyle, J. T. (1998). Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. Am J Psychiatry 155:1207–1213.
   PubMed Web of Science ®Google Scholar
• Unal, B., Bradley, P. M., Sahin, B., Canan, S., Aslan, H., Kaplan, S. (2002). Estimation of numerical density and mean synaptic height in chick hippocampus 24 and 48 hours after passive avoidance training. Dev Brain Res 136:135–144.
   PubMedGoogle Scholar
• Unal, B., Özbek, M. E., Aydın, M. D., Aydın, N., Bulucu, Z., Vuraler, Ö., et al. (2004). Effect of haloperidol on the numerical density of neurons and nuclear height in the rat hippocampus: a stereological and histopathological study. Neurosci Res Commun 34:1–9.
   Google Scholar
• Wakade, C. G., Mahadik, S. P., Waller, J. L., Chiu, F. C. (2002). Atypical neuroleptics stimulate neurogenesis in adult rat brain. J Neurosci Res 69:72–79.
   PubMed Web of Science ®Google Scholar
• Yamamoto, B. K., Cooperman, M. A. (1994). Differential effects of chronic antipsychotic drug treatment on extracellularglutamate and dopamine concentrations. J Neurosci 14:4159–4166.
   PubMed Web of Science ®Google Scholar
• Zhuravliova, E., Barbakadze, T., Natsvlishvili, N., Mikeladze, D. G. (2007). Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity. Neurochem Int 50:976–982.
   PubMed Web of Science ®Google Scholar