Acute effects of thymoquinone on the pregnant rat and embryo-fetal development

References

• Abdelmeguid, N. E., Fakhoury, R., Kamal, S. M., Al Wafai, R. J. (2010). Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic beta-cells of streptozotocin-induced diabetic rats. J Diabetes 2:256–266.
   PubMed Web of Science ®Google Scholar
• Aerts, L., Assche, F. A. (1975). Ultrastructural changes of the endocrine pancreas in pregnant rats. Diabetologia 11:285–289.
   PubMed Web of Science ®Google Scholar
• Ahuja, H. S., Tenniswood, M., Lockshin, R., Zakeri, Z. F. (1994). Expression of clusterin in cell differentiation and cell death. Biochem Cell Biol 72:523–530.
   PubMed Web of Science ®Google Scholar
• Al-Ali, A., Alkhawajah, A. A., Randhawa, M. A., Shaikh, N. A. (2008). Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad 20:25–27.
   PubMedGoogle Scholar
• Al-Naqeeb, G., Ismail, M. (2009). Regulation of apolipoprotien A-1 and apolipoprotien B100 genes by thymoquinone rich fraction and thymoquinone in HepG2 Cells. J Food Lipids 16:245–258.
   Web of Science ®Google Scholar
• Banerjee, S., Padhye, S., Azmi, A., Wang, Z., Philip, P. A., Kucuk, O., et al. (2010). Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer 62:938–946.
   PubMed Web of Science ®Google Scholar
• Badary, O., Al-Shabanah, O. A., Nagi, M. N., Al-Bekairi, A. M., Almazar, M. M. A. (1998). Acute and subchronic toxicity of thymoquinone in mice. Drug Develop Res 44:56–61.
   Web of Science ®Google Scholar
• Badary, O. A., Taha, R. A., Gamal El-Din, A. M., Abdel-Wahab, M. H. (2003). Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 26:87–98.
   PubMed Web of Science ®Google Scholar
• Benhaddou-Andaloussi, A., Martineau, L. C., Vallerand, D., Haddad, Y., Afshar, A., Settaf, A., et al. (2010). Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte, and liver cells. Diabetes Obes Metab 12:148–157.
   PubMed Web of Science ®Google Scholar
• Bertrand, M., Pinton, Y., Pascalon, A., Lepercg, M. F. (1975). Study of the fetal toxicity of alpha tocopherol quinone. Therapie 30:767–776.
   PubMed Web of Science ®Google Scholar
• Bjorklund, A. O., Adamson, U. K., Carlstrom, K. A., Hennen, G., Igout, A., Lins, P. E., et al. (1998). Placental hormones during induced hypoglycaemia in pregnant women with insulin-dependent diabetes mellitus: evidence of an active role for placenta in hormonal counter-regulation. Br J Obstet Gynaecol 105:649–655.
   PubMedGoogle Scholar
• Bolton, J. L., Trush, M. A., Penning, T. M., Dryhurst, G., Monks, T. J. (2000). Role of quinones in toxicology. Chem Res Toxicol 13:135–160.
   PubMed Web of Science ®Google Scholar
• Butt, M. S., Sultan, M. T. (2010). Nigella sativa: reduces the risk of various maladies. Crit Rev Food Sci Nutr 50:654–665.
   PubMed Web of Science ®Google Scholar
• Burits, M., Bucar, F. (2000). Antioxidant activity of Nigella sativa essential oil. Phytother Res 14:323–328.
   PubMed Web of Science ®Google Scholar
• Butler, A. E., Cao-Minh, L., Galasso, R., Rizza, R. A., Corradin, A., Cobelli, C., et al. (2010). Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia 53:2167–2176.
   PubMed Web of Science ®Google Scholar
• Brelje, T., Scharp, D. W., Lacy, P. E., Ogren, L., Talamantes, F., Robertson, M., et al. (1993). Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology 32:879–887.
   Google Scholar
• Brelje, T., Sorenson, R. L. (1997). The physiological roles of prolactin, growth hormone, and placental lactogen in the regulation of islet b-cell proliferation. In: Sarvetnick, N. (Ed.), Pancreas regeneration (pp. 1–23). Austin, Texas, USA: Landes Company Biomedical.
   Google Scholar
• Briggs, G., Freeman, R., Yaffe, S. (2008). Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk (pp. 151, 152, 483). Philadelphia, Pennsylvania, USA: Lippincott Williams & Wilkins.
   Google Scholar
• Calvo, E. L., Mallo, G. V., Fiedler, F., Malka, D., Vaccaro, M. I., Keim, V., et al. (1998). Clusterin overexpression in rat pancreas during the acute phase of pancreatitis and pancreatic development. Eur J Biochem 254:282–289.
   PubMedGoogle Scholar
• Cannon, J. R., Pitha, J. V., Everett, M. A. (1979). Subcutaneous fat necrosis in pancreatitis. J Cutan Pathol 6:501–506.
   PubMed Web of Science ®Google Scholar
• Collins, J. W., Jr., Finley, S. L., Merrick, D., Ogata, E. S. (1988). Human placental lactogen administration in the pregnant rat: acceleration of fetal growth. Pediatr Res 24:663–667.
   PubMed Web of Science ®Google Scholar
• Edris, A. E. (2009). Anti-cancer properties of Nigella spp. essential oils and their major constituents, thymoquinone and β-elemene. Curr Clin Pharmacol 4:43–46.
   Google Scholar
• Effting, C., de Paula, D. J., Nunes, G. D. Jr (2004). A model for the study of skeletal anomalies in rat fetuses. Brazil Arch Biol Technol 47:33–39.
   Web of Science ®Google Scholar
• El-Dakhakhny, M. (1965). Studies on the Egyptian Nigella sativa L. IV. Some pharmacological properties of the seeds’ active principle in comparison to its dihydro compound and its polymer. Arzneimittelforschung 15:1227–1229.
   Google Scholar
• El-Dakhakhny, M., Mady, N., Lembert, N., Ammon, H. P. (2002). The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 68:465–466.
   PubMed Web of Science ®Google Scholar
• Fararh, K. M., Ibrahim, A. K., Elsonosy, Y. A. (2010). Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats. Res Vet Sci 88:400–404
   PubMed Web of Science ®Google Scholar
• Fararh, K. M., Shimizu, Y., Shiina, T., Nikami, H., Ghanem, M. M., Takewaki, T. (2005). Thymoquinone reduces hepatic glucose production in diabetic hamsters. Res Vet Sci 79:219–223.
   PubMed Web of Science ®Google Scholar
• Freemark, M. (2010). Placental hormones and the control of fetal growth. J Clin Endocrinol Metab 95:2054–2057.
   PubMed Web of Science ®Google Scholar
• French, L. E., Chonn, A., Ducrest, D., Baumann, B., Belin, D., Wohlwend, A., et al. (1993). Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis. J Cell Biol 122:1119–1130.
   PubMed Web of Science ®Google Scholar
• Gali-Muhtasib, H., Roessner, A., Schneider-Stock, R. (2006). Thymoquinone: a promising anti-cancer drug from natural sources. Int J Biochem Cell Biol 38:1249–1253.
   PubMed Web of Science ®Google Scholar
• Gumaste, V. V. (1996). Hyperlipidemia and pancreatitis: the chicken or the egg? Am J Gastroenterol 91:1275–1276.
   PubMedGoogle Scholar
• Gianfrate, L., Ferraris, L. (1998). Acute pancreatitis, hyperlipidemia, and diabetic ketoacidosis: who comes first?. Am J Gastroenterol 98:1393–1394.
   Google Scholar
• Handwerger, S. (1988). Human placental lactogen and fetal growth. Growth Genet Horm 4:5–8.
   Google Scholar
• Handwerger, S., Freemark, M. (2000). The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development. J Pediatr Endocrinol Metab 13:343–356.
   PubMed Web of Science ®Google Scholar
• Handwerger, S., Myers, S., Richards, R., Richardson, B., Turzai, L., Moeykins, C., et al. (1995). Anantharamahiah GM. Apolipoprotein A-I stimulates placental lactogen expression by human trophoblast cells. Endocrinology 136:5555–5560.
   Google Scholar
• Handwerger, S., Quarfordt, S., Barrett, J., Harjn, I. (1987). Apolipoproteins AI, AII, and CI stimulate placental lactogen release from human placental tissue. A novel action of high density lipoprotein apolipoproteins. J Clin Invest 79:625–628.
   Google Scholar
• Hawsawi, Z. A., Ali, B. A., Bamosa, A. O. (2001). Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann Saudi Med 21:242–244.
   PubMed Web of Science ®Google Scholar
• Ivankovic, S., Stojkovic, R., Jukic, M., Milos, M., Milos, M., Jurin, M. (2006). The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo. Exp Oncol 28:220–224.
   PubMedGoogle Scholar
• Josimovich, J. B., Mintz, D. H. (1968). Biological and immunochemical studies on human placental lactogen. Ann N Y Acad Sci 148:488–500.
   PubMed Web of Science ®Google Scholar
• Kanda, Y., Richards, R. G., Handwerger, S. (1998). Apolipoprotein A-I stimulates human placental lactogen release by activation of MAP kinase. Mol Cell Endocrinol 143:125–131.
   PubMed Web of Science ®Google Scholar
• Karabulut, A. K., Layfield, R., Pratten, M. K. (2001). Growth promoting effects of human placental lactogen during early organogenesis: a link to insulin-like growth factors. J Anat 198:651–562.
   PubMed Web of Science ®Google Scholar
• Kawai, M., Kishi, K. (1997). In vitro studies of the stimulation of insulin secretion and B-cell proliferation by rat placental lactogen-II during pregnancy in rats. J Reprod Fertil 109:145–152.
   PubMedGoogle Scholar
• Khader, M., Bresgen, N., Eckl, P. M. (2009). In vitro toxicological properties of thymoquinone. Food Chem Toxicol 47:129–133.
   PubMed Web of Science ®Google Scholar
• Krasavage, W. J., Blacker, A. M., English, J. C., Murphy, S. J. (1992). Hydroquinone: a developmental toxicity study in rats. Fundam Appl Toxicol 18:370–375.
   PubMedGoogle Scholar
• Mansour, M. A., Ginawi, O. T., El-Hadiyah, T., El-Khatib, A. S., Al-Shabanah, O. A., Al-Sawaf, H. A. (2001). Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Res Commun Mol Pathol Pharmacol 110:239–251.
   PubMedGoogle Scholar
• Mansour, M. A., Nagi, M. N., El-Khatib, A. S., Al-Bekairi, A. M. (2002). Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation, and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 20:143–151.
   PubMed Web of Science ®Google Scholar
• Mathur, M. L., Gaur, J., Sharma, R., Haldiya, K. R. (2011). Antidiabetic properties of a spice plant Nigella sativa. J Endocrinol Metabol 1:1–8.
   Google Scholar
• Murphy, S. J., Schroeder, R. E., Blacker, A. M., Krasavage, W. J., English, J. C. (1992). A study of developmental toxicity of hydroquinone in the rabbit. Fundam Appl Toxicol 19:214–221.
   PubMedGoogle Scholar
• Mutabagani, A., El-Mahdy, S. (1997). A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone. Saudi Pharm J 5:110–113.
   Google Scholar
• Ogata, E. S., Paul, R. I., Finley, S. L. (1987). Limited maternal fuel availability due to hyperinsulinemia retards fetal growth and development in the rat. Pediatr Res 22:432–437.
   PubMed Web of Science ®Google Scholar
• Padhye, S., Banerjee, S., Ahmad, A., Mohammad, R., Sarkar, F. H. (2008). From here to eternity—the secret of pharaohs: therapeutic potential of black cumin seeds and beyond. Cancer Ther 6:495–510.
   PubMedGoogle Scholar
• Pari, L., Sankaranarayanan, C. (2009). Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats. Life Sci 85:830–834.
   PubMed Web of Science ®Google Scholar
• Pierzynowski, S., Zabielski, R. (1999). Biology of the pancreas in growing animals (p. 45). Amsterdam: Elsevier Science.
   Google Scholar
• Qadri, S. M., Mahmud, H., Foller, M., Lang, F. (2009). Thymoquinone-induced suicidal erythrocyte death. Food Chem Toxicol 47:1545–1549.
   PubMed Web of Science ®Google Scholar
• Raja, S. (2007). Access to surgery: 500 SBAs in general and systemic physiology (p. 511). Cheshire, UK: Pastest.
   Google Scholar
• Rooney, S., Ryan, M. F. (2005). Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res 25:2199–2204.
   PubMed Web of Science ®Google Scholar
• Sadler, T. W., Hunter, E. S. (1987). Hypoglycemia: how little is too much for the embryo? Am J Obstet Gynecol 157:190–193.
   PubMed Web of Science ®Google Scholar
• Salem, M. L. (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Intl Immunopharmacol 5:1749–1770.
   PubMed Web of Science ®Google Scholar
• Schoknecht, P. A., Nobrega, S. N., Petterson, J. A., Ehrhardt, R. A., Slepetis, R., Bell, A. W. (1991). Relations between maternal and fetal plasma concentrations of placental lactogen and placental and fetal weights in well-fed ewes. J Anim Sci 69:1059–1063.
   PubMed Web of Science ®Google Scholar
• Shimizu, Y., Takahiko, S., El-Mahkoudy, A., Hideki, N., Tadashi, T. (2004). Mechanism of the pharmacological actions of a plant-derived active compound, thymoquinone. Vet Biochem 41:15–21.
   Google Scholar
• Shoieb, M., Elgayyar, M., Dudrick, S., Bell, L., Tithof, K. (2003). In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 22:107–113.
   PubMed Web of Science ®Google Scholar
• Smoak, I. W., Sadler, T. W. (1990). Embryopathic effects of short-term exposure to hypoglycemia in mouse embryos in vitro. Am J Obstet Gynecol 163:619–624.
   PubMed Web of Science ®Google Scholar
• Smith, J. P., Arnoletti, J. P., Varadarajulu, S., Morgan, D. E. (2008). Post-pancreatitis fat necrosis mimicking carcinomatosis. Radiol Case Rep 3:1–4.
   Google Scholar
• Sorenson, R. L., Brelje, T. C. (1997). Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion, and the role of lactogenic hormones. Horm Metab Res 29:301–307.
   PubMed Web of Science ®Google Scholar
• Tonkowicz, P., Robertson, M., Voogt, J. (1983). Secretion of rat placental lactogen by the fetal placenta and its inhibitory effect on prolactin surges. Biol Reprod 28:707–716.
   PubMed Web of Science ®Google Scholar
• Tonkowicz, P. A., Voogt, J. L. (1983). Examination of rat placental lactogen and prolactin at 6-hr intervals during midpregnancy. Proc Soc Exp Biol Med 173:583–587.
   PubMed Web of Science ®Google Scholar
• Williams, C., Coltart, T. M. (1978). Adipose tissue metabolism in pregnancy: the lipolytic effect of human placental lactogen. Br J Obstet Gynaecol 85:43–46.
   PubMedGoogle Scholar
• Woolley, D. W. (1945). Some biological effects produced by alpha-tocopherol quinone. J Biol Chem 159:59–66.
   Web of Science ®Google Scholar