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Research Article

Investigation of antigenotoxic potential of Syzygium cumini extract (SCE) on cyclophosphamide-induced genotoxicity and oxidative stress in mice

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Pages 396-402 | Received 05 Apr 2012, Accepted 05 Oct 2012, Published online: 09 Jan 2013

References

  • Abalea V, Cillard J, Dubos MP, et al. (1999). Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures. Free Radic Biol Med 26:1457–66
  • Abdel-Wahhab MA, Aly SE. (2003). Antioxidants and radical scavenging properties of vegetable extracts in rats fed aflatoxin contaminated diet. J Agric Food Chem 51:2409–14
  • Abdel-Wahhab MA, Aly SE. (2005). Antioxidant property of Nigella sativa (Black cumin) and Syzygium aromaticum (Clove) in rats during aflatoxicosis. J Appl Toxicol 25:218–23
  • Aebi H. (1974). Catalase. In: Bergmayer HU, ed. Methods of Enzymatic Analysis. New York/London: Verlag Chemie Academic, 673–84
  • Anil KP, Diptirani S, Ramesh CC. (1999). Cytosine arabinoside-induced cytogenotoxicity in bone marrow and spermatogonial cells of mice and its potential transmission through the male germline. Mutat Res 673:29–36
  • Arumugam N, Sivakumar V, Thanislass J, Devaraj H. (1997). Effects of acrolein on rat liver antioxidant defense system. Indian J Exp Biol 35:1373–74
  • Au WW, Hsu TC. (1980). The genotoxic effects of adriamycin in somatic and germinal cells of mouse. Mutat Res 79:351–61
  • Bhuiyan MA, Mia MY, Rashid MA. (1996). Antibacterial principles of the seeds of Eugenia jambolana. Bangladesh J Biol 25:239–41
  • Block G. (1992). The data support a role for antioxidants in reducing cancer risk. Nutr Rev 50:207–13
  • Brookes P. (1990). The early history of the biological alkylating agents. Mutat Res 233:3–14
  • Bruce WR, Furrer R, Wyrobek AJ. (1974). Abnormalities in the shape of murine sperm after acute testicular X-irradiation. Mutat Res 23:381–6
  • Chaudhuri AKN, Pal S, Games A, Bhattacharya S. (1990). Anti-inflammatory and related actions of Syzigium cummini seed extract. Phytother Res 4:5–10
  • Chopra RN, Chopra IC, Handa KL, Kapur LD. (1958). Chopr’s indigenous drugs of India, 2nd ed. Calcutta, India: UN Dhar and Sons Pvt. Ltd, 686–9
  • Cole R, Cole C. (1979). Transplacental effects of chemical mutagens detected by the micronucleus test. Nature 277:317–18
  • De Salvia R, Fiore M, Aglitti T, et al. (1999). Inhibitory action of melatonin on H2O2- and cyclophosphamide-induced DNA damage. Mutagenesis 14:107–12
  • Dumontet C, Drai J, Thieblemont C. (2001). The superoxide dismutase content in erythrocytes predicts short-term toxicity of high-dose cyclophosphamide. Br J Haematol 112:405–9
  • Ferguson LR. (2001). Role of plant polyphenols in genomic stability. Mutat Res 475:89–111
  • Fernando M, Peralta L, Raviolo J, et al. (2009). Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests. Environ Toxicol Pharmacol 28:37–41
  • Flora, SD. (1998). Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat Res 402:151–8
  • Flora S, Izzotti DA, Agostini FD, et al. (2001). Multiple points of intervention in the prevention of cancer and other mutation-related diseases. Mutat Res 480–481:9–22
  • Fraiser LH, Kanekal S, Kehrer JP. (1991). Cyclophosphamide toxicity. Drugs 42:781–95
  • Ghosh MN. (1984). Toxicity studies. In: Ghosh MN, ed. Fundamentals of experimental pharmacology. Calcutta, India: Scientific Book Agency, 153–8
  • Grover JK, Yadav S, Vats V. (2002). Medicinal plants of India with antidiabetic potential. J Ethanopharmacol 81:81–100
  • Guadalupe LP, Paul AK, Elvira GM, et al. (1996). Antimutagenicity of ellagic acid against aflatoxin B 1 in the Salmonella microsuspension assay. Mutat Res 360:15–21
  • Ho CT. (1992). Phenolic compounds in food: an overview. In: Huang MT, Ho CT, Lee CY, eds. Phenolic compounds in food and their effects on health II. Antioxidants and cancer prevention. Washington, DC: American Chemical Society, 2–7
  • Jackson MA, Stack HF, Waters MD. (1996). Genetic activity profiles of anticancer drugs. Mutat Res 355:171–208
  • Jadhav VM, Kamble SS, Kadam VJ. (2009). Herbal medicine: Syzygium cumini: a review. J Pharm Res 2: 8:1212–19
  • Jagetia GC, Baliga MS. (2002). Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study. Toxicol Lett 132:19–25
  • Kapiszewska M, Cierniak A, Papiez MA, et al. (2007). The prolonged quercetin administration diminishes the etoposide-induced DNA damage in bone marrow cells of rats. Drug Chem Toxicol 30: 1:67–80
  • Kaura S, Aroraa S, Kaura K, Kumar S. (2002). The in vitro antimutagenic activity of Triphala – an Indian herbal drug. Food Chem Toxicol 40:527–34
  • Kawanishi M, Matsuda T, Nakayama A, et al. (1998). Molecular analysis of mutations induced by acrolein in human fibroblast cells using supF shuttle vector plasmids. Mutat Res 417:65–73
  • Kehrer JP, Biswal SS. (2000). The molecular effect of acrolein. Toxicol Sci 57:6–15
  • Kern JC, Kehrer JP. (2002). Acrolein-induced cell death: a caspase influenced decision between apoptosis and oncosis/necrosis. Chem Biol Interact 139:79–95
  • Korina LG, Afanas'ev IB. (1997). Antioxidant and chelating properties of flavonoids. Adv Pharmacol 38:151–63
  • Kuo ML, Lee KC, Lin JK. (1992). Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems. Mutat Res 270:87–95
  • Kusumoto IT, Nakabayashi T, Kida H, et al. (1995). Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type I (HIV-I) protease. Phytother Res 12:488–93
  • Lambert IB, Singer TM, Boucher SE, Douglas GR. (2005). Detailed review of transgenic rodent mutation assays. Mutat Res 590:1–280
  • Lambert JD, Yang CS. (2003). Mechanisms of cancer prevention by tea constituents. J Nutr 133:3262S–7S
  • Lear L, Nation RL, Stupans I. (1992). Effects of cyclophosphamide and adriamycin on rat hepatic microsomal glucuronidation and lipid peroxidation. Biochem Pharmacol 44:747–53
  • Loadman PM, Bibby MC. (1994). Pharmacokinetic drug interactions with anti-cancer drugs. Clin Pharmacokinet 26:486–500
  • Lopes GK, Schulman HM, Hermes-Lima M. (1999). Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochim Biophys Acta 1472:142–52
  • Lowry OH, Rosebrough JN, Farr AL, Randall RJ. (1951). Protein measurement with the Folin reagent. J Biol Chem 193:265–75
  • Maridonneau PI, Braquet P, Garay RP. (1986). Heterogeneous effect of flavonoids on K+ loss and lipid peroxidation induced by oxygen-free radicals in human red cells. Pharmacol Res Commun 18:61–72
  • Mathew S, Kuttan G. (1997). Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J Exp Clin Cancer Res 16:407–11
  • Mazur L, Augustynek A, Bochenek M. (2002). Flow cytometric estimation of the plasma membrane diversity of bone marrow cells in mice treated with WR-2721 and cyclophosphamide. Toxicology 171:63–72
  • Misra HP, Fridovich I. (1972). The role of superoxide anion in the antioxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:31–70
  • Mitchell JR, Jollow DJ, Potter WZ, et al. (1973). Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187:211–17
  • Moon YH, Lee HJ, Sohn SJ, William WA. (1996). Anticlastogenic effects of galangin against mitomycin C-induced micronuclei in reticulocytes of mice. Mutat Res 360:37–41
  • Moore MJ. (1991). Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet 20:194–208
  • Morrison H, Jernstrom B, Nordenskjold M, et al. (1984). Induction of DNA damage by menadione (2-methyl-l, 4-naphthoquinone) in primary cultures of rat hepatocytes. Biochem Pharmacol 33:1763–69
  • Mythili Y, Sudharsan PT, Selvakumar E, Varalakshmi P. (2004). Protective effect of dl lipoic acid on cyclophosphamide induced oxidative cardiac injury. Chem Biol Interact 151:13–19
  • Nakagawa K, Hidaka T, Kitano M, et al. (2008). Genotoxicity studies on licorice flavonoid oil (LFO). Food Chem Toxicol 46:2525–32
  • Nakayama T. (1994). Suppression of hydroperoxide-induced cytotoxicity by polyphenols. Cancer Res 54(7 Suppl.):1991s–3s
  • Nakayama T, Yamada M, Osawa T, Kawakishi S. (1993). Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochem Pharmacol 45:265–7
  • Ohkawa I, Ohisi N, Yagi K. (1979). Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 95:351–8
  • Park EJ, Pezzuto JM. (2002). Botanicals in cancer chemoprevention. Cancer Metastasis Rev 21:231–55
  • Premkumar K, Pachiappan A, Abraham SK. (2001). Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice. Fitoterapia 72:906–11
  • Preston RJ, Dean BJ, Galloway S, et al. (1987). Mammalian in vivo cytogenetics assays: analysis of chromosome aberrations in bone marrow cells. Mutat Res 189:157–65
  • Prieur DJ, Young DM Davis RD. (1973). Procedure for preclinical toxicological evaluation of cancer chemotherapeutic agents: protocol for laboratory toxicology. Cancer Chemother Rep 4:1–28
  • Qiu HZ, Chun FW, Lian D, Jing YY. (2008). Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells. Food Chem Toxicol 46:293–302
  • Rabello-Gay MN. (1991). Micronucleus test in bone marrow. In: Rabello-Gay MN, Rodrigues MAR, Monteleone-Neto R, Mutagenesis, carcinogenesis, and teratogenesis: methods and evaluation criteria. Ribeirão Preto, São Paulo, Brazil: Brazilian Society of Genetics, 83–90
  • Rastogi RM, Mehrotra BN. (1990). Compendium of Indian medicinal plant (1). Lucknow, India: Central Drug Research Institute, Lucknow India, 388–9
  • Salamone MF, Heddle JA. (1983). The bone marrow micronucleus assay: rationale for a revised protocol. In: de Serres FJ, ed. Chemical mutagens: principles and methods for their detection. New York: Plenum, 111–49
  • Schmid W. (1975). The micronucleus test. Mutat Res 35:9–15
  • Singleton LV, Orthofer R, Lamuela-Raventos RML. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Method Enzymol 299:152–78
  • Sladek NE. (1971). Metabolism of cyclophosphamide by rat hepatic microsomes. Cancer Res 31:901–8
  • Sladek NE. (1988). Metabolism of oxazaphosphorines. Pharmacol Ther 37:301–55
  • Stoner GD, Mukhtar H. (1995). Polyphenols as cancer chemopreventive agents. J Cell Biochem 22:169–80
  • Subramanian S, Surinder KY, Rajakannu S, Thiruvengadam D. (2006). Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. Chem Biol Interact 160:252–60
  • Tanaka T. (1994). Cancer chemoprevention by natural products. Oncol Rep 1:1139–55
  • Teel RW. (1986). Ellagic acid binding to DNA as a possible mechanism for its antimutagenic and anticarcinogenic action. Cancer Lett 30:329–36
  • Teitz F. (1967). Enzymatic method of quantitative determination of nanogram amounts of total and oxidized glutathione. Anal Biochem 27:502–50
  • Tice RR, Luke CA, Shelby MD. (1987). Methyl isocynate: an evaluation of in vivo cytogenetic activity. Environ Mutagen 9:37–58
  • Tripathi P, Tripathi R, Patel RK, Pancholi SS. (2013). Investigation of antimutagenic potential of Foeniculum vulgare essential oil on cyclophosphamide induced genotoxicity and oxidative stress in mice. Drug Chem Toxicol 36:35–41
  • Tzyh-Chyuan H, Yu-Chih L. (1999). Inhibition of eleven mutagens by various tea extracts, (-)-epigallocatechin-3-gallate, gallic acid, and caffeine. Food and Chem Toxicol 37:569–79
  • Valko M, Leibfritz D, Moncol J, et al. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44–84
  • VanderJagt TJ, Ghattas R, VanderJagt DJ, et al. (2002). Comparison of the total antioxidant content of 30 widely used medicinal plants of New Mexico. Life Sci 70:1035–40
  • Varmus H, Weinberg RA. (1993). Genes and biology of cancer. New York: Scientific America Library
  • Venkatesan N, Chandrakasan G. (1995). Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol Cell Biochem 142:79–87
  • Weisburger JH. (2001). Antimutagenesis and anticarcinogenesis from the past to future. Mutat Res 480–481:23–35
  • Woisky R, Salatino A. (1998). Analysis of propolis: some parameters and procedures for chemical quality control. J Apicult Res 37:99–105
  • Yu R, Jiao JJ, Duh JL, et al. (1997). Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression. Carcinogenesis 18:451–6

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