Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis

References

• Adjei AA. (2001). Blocking oncogenic ras signaling for cancer therapy. J Natl Cancer Inst 93:1062–1073
   PubMed Web of Science ®Google Scholar
• Alvaro-Gracia JM. (2004). Licofelone-clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology 43:21–25
   PubMed Web of Science ®Google Scholar
• Campbell PM, Der CJ. (2004). Oncogenic ras and its role in tumor cell invasion and metastasis. Semin Cancer Biol 14:105–114
   PubMed Web of Science ®Google Scholar
• Cao Y, Pearman AT, Zimmerman GA, et al. (2000). Intracellular unesterified arachidonic acid signals apoptosis. Proc Natl Acad Sci U S A 97:11280–11285
   PubMed Web of Science ®Google Scholar
• Claria J, Romano M. (2005). Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer. Curr Pharm Des 11:3431–3447
   PubMed Web of Science ®Google Scholar
• Claria J. (2003). Cyclooxygenase-2 biology. Curr Pharm Des 9:2177–2190
   PubMed Web of Science ®Google Scholar
• Ding XZ, Iversen P, Cluck MV, et al. (1999). Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. Biochem Biophys Res Commun 261:218–223
   PubMed Web of Science ®Google Scholar
• Engeland MV, Nieland JWL, Ramaekers FCS, et al. (1998). Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31:1–9
   PubMedGoogle Scholar
• Gao J, Fan HR, Mei LY. (2010). Pharmacological activities and pharmacokinetics of licofelone. Asian J Pharmacodyn Pharmacokinet 4:287–299
   Google Scholar
• Ganesh R, Marks DJ, Sles K, et al. (2012). Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. World J Surg Oncol 10:200 . doi: 10.11.1186/1477-7819-10-200
   PubMed Web of Science ®Google Scholar
• Gupta S, Srivastava M, Ahmad N, et al. (2001). Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. Cancer 91:737–743
   PubMed Web of Science ®Google Scholar
• Hajighasemi F, Mirshafiey A. (2009). In vitro sensitivity of leukemia cells to propranolol. J Clin Med Res 1:144–149
   PubMedGoogle Scholar
• Herr I, Debatin KM. (2001). Cellular stress response and apoptosis in cancer therapy. Blood 98:2603–2614
   PubMed Web of Science ®Google Scholar
• Hu KQ, Yu CH, Mineyama Y, et al. (2003). Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor. Int J Oncol 22:757–763
   PubMed Web of Science ®Google Scholar
• Huerta S, Gaulet EJ, Huerta-Yepez S, Livingston EH. (2007). Screening and detection of apoptosis. J Surg Res 139:143–156
   PubMed Web of Science ®Google Scholar
• Hyde CAC, Missailidis S. (2009). Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis. Int Immunopharmacol 9:701–705
   PubMed Web of Science ®Google Scholar
• Incesu Z, Kutlu M, Saltan N, Iscan A. (2009). Morphological effects of folic acid on ras transformed cell line by using a transmission electron microscope. Anadolu University J Sci Technol 10:215–222
   Google Scholar
• Isıkdag I, Incesu Z, Gulnaz D, Ozkay Y. (2008). Cytotoxic effects of some perimidine derivates on F2408 and 5RP7 cell lines. FABAD J Pharm Sci 33:135–143
   Google Scholar
• Jiang WG, Douglas JA, Mansel RE. (2003). Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. Prostaglandins Leukot Essent Fatty Acids 69:275–281
   PubMed Web of Science ®Google Scholar
• Kalluri R, Zeisberg M. (2006). Fibroblasts in cancer. Nat Rev Can 6:392–401
   PubMed Web of Science ®Google Scholar
• Kamijo T, Sato T, Nagotomi Y, Kitamura T. (2001). Induction apoptosis by cyclooxygenase-2 inhibitors in prostate cell lines. Int J Urol 8:35–39
   PubMed Web of Science ®Google Scholar
• Koontongkaew S, Leelahavanichkul K. (2012). Arachidonic acid metabolism and its implication on head and neck cancer. Head Neck Cancer 236:167–183
   Google Scholar
• Kundu N, Yang Q, Dorsey R, Fulton AM. (2001). Increased cyclooxygenase-2 expression and activity in a murine model of metastatic breast cancer. Int J Cancer 93:681–686
   PubMed Web of Science ®Google Scholar
• Kurkjian C, Janakiram NB, Guruswamy S, et al. (2007). The effects of licofelone, a dual lipoxygenase and cyclooxygenase inhibitor, with and without rosiglitazone in human MCF-7 and MDA-MB-231 breast cancer cells. J Clin Oncol 25:1537
   Google Scholar
• Li N, Sood S, Wang S, et al. (2005). Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res 11:2089–2096
   PubMed Web of Science ®Google Scholar
• Liu W, Zhou J, Bensdorf K, et al. (2011). Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivates. Eur J Med Chem 46:907–913
   PubMed Web of Science ®Google Scholar
• Melstrom LG, Bentrem DJ, Salabat MR, et al. (2008). Overexpression of 5-Lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin Can Res 14:6525–6530
   PubMed Web of Science ®Google Scholar
• Mohammed A, Janakiram NB, Li Q, et al. (2011). Chemoprevention of colon and small intestinal tumorigenesis in apcmin/+ mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention. Cancer Prev Res 4:2015–2026
   PubMed Web of Science ®Google Scholar
• Mossmann T. (1983). Rapid colorimetric assay of cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods 65:55–63
   PubMed Web of Science ®Google Scholar
• Nakagawa H, Liyanarachchi S, Davuluri RV, et al. (2004). Role of cancer associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles. Oncogene 23:7366–7377
   PubMed Web of Science ®Google Scholar
• Narayanan K, Nargi D, Attur M, et al. (2007). Anticancer effects of licofelone in prostate cancer cells. Anticancer Res 27:2393–2402
   PubMed Web of Science ®Google Scholar
• Osaki M, Tatebe S, Goto A, et al. (1997). 5-Fluorouracil (5-FU) induces apoptosis in gastric cancer cell lines: role of the p53 gene. Apoptosis 2:221–226
   PubMed Web of Science ®Google Scholar
• Ravindran J, Prasad S, Aggarwal BB. (2009). Circumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 11:595–610
   Google Scholar
• Riedl SJ, Shi Y. (2004). Molecular mechanisms of caspase regulation during apoptosis. Mol Cell Biol 5:897–907
   Google Scholar
• Romano M, Claria J. (2003). Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J 17:1986–1995
   PubMed Web of Science ®Google Scholar
• Salseven GS, Dixit VM. (1999). Caspase activation: the induced proximity model. Proc Natl Acad Sci U S A 96:10964–10967
   PubMed Web of Science ®Google Scholar
• Sánchez-Alcázar JA, Bradbury DA, Pang L, Knox AJ. (2003). Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. Lung Cancer 40:33–44
   PubMed Web of Science ®Google Scholar
• Schroeder CP, Yang P, Newman RA, Lotan R. (2007). Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines. Exp Ther Oncol 6:183–192
   PubMedGoogle Scholar
• Sigal E. (1991). The molecular biology of mammalian arachidonic acid metabolism. Lung Physiol 260:13–28
   Google Scholar
• Smith WL, Murphy RC. (2002). The eicosanoids: cyclooxygenase, lipoxygenase and epoxygenase pathways. In: Biochemistry of lipids, lipoproteins and membranes. 4th ed. Amsterdam: Elsevier Science B.V., 341--371
   Google Scholar
• Takahashi T, Kozaki K, Yatabe Y, et al. (2002). Increased expression of COX-2 in the development of human lung cancers. J Environ Pathol Toxicol Oncol 21:177–181
   PubMedGoogle Scholar
• Takeda M, Suzuki Y, Obara N, Agai Y. (2000). Induction of apoptosis by colchicine in taste bud and epithelial cells of the mouse circumvallate papillae. Cell Tissue Res 302:391–395
   PubMed Web of Science ®Google Scholar
• Tauler J, Mulshine JL. (2008). Combination therapy of PPARgamma ligands and inhibitors of arachidonic acid in lung cancer. PPAR Res 2008:750238 . doi: 10-1155/2008/750238
   PubMedGoogle Scholar
• Tavolari S, Bonafè M, Marini M, et al. (2008). Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 29:371–380
   PubMed Web of Science ®Google Scholar
• Ye NY, Wu WKK, Shin VY, et al. (2005). Dual inhibition of 5-LOX and COX-2 supresses colon cancer formation promoted by cigarette smoke. Carcinogenesis 26:827–834
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang CL, Zhao WH, et al. (2008). Effect of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2. World J Gastroenterol 28:2494–2500
   Google Scholar