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Research Article

Screening of herbal components for attenuating amiodarone-induced hepatotoxicity on gel-entrapped rat hepatocytes

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Pages 100-106 | Received 13 Nov 2012, Accepted 23 Jun 2013, Published online: 26 Nov 2013

References

  • Agoston M, Orsi F, Feher E, et al. (2003). Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats. Toxicology 190:231–241
  • Berson A, De Beco V, Letteron P, et al. (1998). Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 114:764–774
  • Donato MT, Lahoz A, Jimenez N, et al. (2006). Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug Metab Dispos 34:1556–1562
  • Emaus RK, Grunwald R, Lemasters JJ. (1986). Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 850:436–448
  • Fromenty B, Fisch C, Labbe G, et al. (1990). Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther 255:1371–1376
  • Harjai KJ, Licata AA. (1997). Effects of amiodarone on thyroid function. Ann Intern Med 126:63–73
  • Jessurun GA, Boersma WG, Crijns HJ. (1998). Amiodarone-induced pulmonary toxicity. Predisposing factors, clinical symptoms and treatment. Drug Saf 18:339–344
  • Kaufmann P, Torok M, Hanni A, et al. (2005). Mechanisms of benzarone and benzbromarone-induced hepatic toxicity. Hepatology 41:925–935
  • Kelly JP, Kaufman DW, Kelley K, et al. (2005). Recent trends in use of herbal and other natural products. Arch Intern Med 165:281–286
  • Kim YC, Kim EJ, Lee ED, et al. (2003). Comparative bioavailability of silibinin in healthy male volunteers. Int J Clin Pharm Th 41:593–596
  • Lewis JH, Ranard RC, Caruso A, et al. (1989). Amiodarone hepatotoxicity: prevalence and clinicopathologic correlations among 104 patients. Hepatology 9:679–685
  • Lu Y, Dai J, Shen C, et al. (2009). Primary throughput screening of protectants for hypothermic preservation of bioartificial liver in gel entrapped hepatocytes. Biochem Eng J 44:160–166
  • Masubuchi Y, Kano S, Horie T. (2006). Mitochondrial permeability transition as a potential determinant of hepatotoxicity of antidiabetic thiazolidinediones. Toxicology 222:233–239
  • Meng Q, Zhang G, Shen C, Qiu H. (2006). Sensitivities of gel entrapped hepatocytes in hollow fibers to hepatotoxic drug. Toxicol Lett 166:19–26
  • Miguet-Alfonsi C, Prunet C, Monier S, et al. (2002). Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7β-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. Biochem Pharmacol 64:527–541
  • Morse RM, Valenzuela GA, Greenwald TP, et al. (1988). Amiodarone-induced liver toxicity. Ann Intern Med 109:838–840
  • Negi AS, Kumar JK, Luqman S, et al. (2008). Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads. Med Res Rev 28:746–772
  • Nieusma JL, Claffey DJ, Ruth JA, Ross D. (1998). Stereochemical aspects of the conjugation of epoxide metabolites of butadiene with glutathione in rat liver cytosol and freshly isolated rat hepatocytes. Toxicol Sci 43:102–109
  • Ouazzani-Chahdi A, Elimadi A, Chabli A, et al. (2007). Combining ursodeoxycholic acid or its NO-releasing derivative NCX-1000 with lipophilic antioxidants better protects mouse hepatocytes against amiodarone toxicity. Can J Physiol Pharmacol 85:233–242
  • Pollak PT. (1999). Clinical organ toxicity of antiarrhythmic compounds: ocular and pulmonary manifestations. Am J Cardiol 84:37R–45R
  • Ruch RJ, Bandyopadhyay S, Somani P, Klaunig JE. (1991). Evaluation of amiodarone free-radical toxicity in rat hepatocytes. Toxicol Lett 56:117–126
  • Shen C, Zhang G, Meng Q. (2010a). Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber. Toxicol Appl Pharmacol 249:140–147
  • Shen C, Zhang G, Meng Q. (2010b). Evaluation of amiodarone-induced phospholipidosis by in vitro system of 3D cultured rat hepatocytes in gel entrapment. Biochem Eng J 49:308–316
  • Singh BN. (1996). Antiarrhythmic actions of amiodarone: a profile of a paradoxical agent. Am J Cardiol 78:41–53
  • Sirajudeen KN, Gurumoorthy P, Devaraj H, Devaraj SN. (2002). Amiodarone-induced phospholipidosis: an in vivo [14C]-acetate uptake study in rat. Drug Chem Toxicol 25:247–254
  • Vejux A, Kahn E, Dumas D, et al. (2005). 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation. Cytometry Part A 64:87--100
  • Vejux A, Kahn E, Ménétrier F, et al. (2007). Cytotoxic oxysterols induce caspase-independent myelin figure formation and Caspase-dependent polar lipid accumulation. Histochem Cell Biol 127:609--624
  • Vejux A, Guyot S, Montange T, et al. (2009). Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. J Nutr Biochem 20:45–61
  • Wang HZ, Chang CH, Lin CP, Tsai MC. (1996). Using MTT viability assay to test the cytotoxicity of antibiotics and steroid to cultured porcine corneal endothelial cells. J Ocul Pharmacol Ther 12:35–43
  • Wong SH, Knight JA, Hopfer SM, et al. (1987). Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33:214–220
  • Wu X, Yamashita F, Hashida M, et al. (2003). Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Talanta 59:965--971
  • Wu DQ, Zhang GL, Shen C, et al. (2005). Evaluation of diffusion in gel entrapment cell culture within hollow fibers. World J Gastroenterol 11:1599–1604
  • Yuan R, Lin Y. (2000). Traditional Chinese medicine: an approach to scientific proof and clinical validation. Pharmacol Therapeut 86:191--198
  • Zaki MS, Eid RA. (2009). Role of vitamin-E on rat liver-amiodarone: an ultrastructural study. Saudi J Gastroenterol 15:104–110

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