301
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Enhanced cytotoxic and genotoxic effects of gadolinium following ELF-EMF irradiation in human lymphocytes

, , , &
Pages 440-447 | Received 08 Aug 2013, Accepted 28 Dec 2013, Published online: 30 Jan 2014

References

  • Abraham JL, Thakral C, Skov L, et al. (2008). Dermal inorganic gadolinium concentrations: evidence for in vivo transmetallation and long-term persistence in nephrogenic systemic fibrosis. Br J Dermatol 158:273–280
  • Adding LC, Bannenberg GL, Gustafsson LE. (2001). Basic experimental studies and clinical aspects of gadolinium salts and chelates. Cardiovascular Drug Rev 19:41–56
  • Allen RG, Burstein D, Gray ML. (1999). Monitoring glycosaminoglycan replenishment in cartilage explants with gadolinium-enhanced magnetic resonance imaging. J Orthop Res 17:430–436
  • Bashir A, Gray ML, Boutin RD, Burstein D. (1997). Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 205:551–558
  • Bashir A, Gray ML, Hartke J, Burstein D. (1999). Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 41:857–865
  • Bertin A, Michou-Gallani AI, Gallani JL, Felder-Flesch D. (2010). In vitro neurotoxicity of magnetic resonance imaging (MRI) contrast agents: influence of the molecular structure and paramagnetic ion. Toxicol In Vitro 24:1386–1394
  • Broome DR. (2008). Nephrogenic systemic fibrosis associated with gadolinium-based contrast agents: a summary of the medical literature reporting. Eur J Radiol 66:230–234
  • Buttke TM, Sandstrom PA. (1994). Oxidative stress as a mediator of apoptosis. Immunol Today 15:7–10
  • Caravan P, Ellison JJ, McMurry TJ, Lauffer RB. (1999). Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev 99:2293–2352
  • Caroline R, Sarah C, De Marie-Christine G, et al. (2011). The role of phosphate on Omniscan (R) dechelation: an in vitro relaxivity study at pH 7. Biometals 24:759–768
  • Cho YH, Chung HW. (2003). The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene. Toxicol Lett 143:37–44
  • Evill CA, Wilson AJ, Fletcher MC, Sage MR. (1996). Neurotoxicity of contrast media for magnetic resonance imaging after generalized breakdown of the blood-brain barrier. Acad Radiol 3:S336–S338
  • Fenech M. (1993). The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35–44
  • Fenech M. (2000). The in vitro micronucleus technique. Mutat Res 455:81–95
  • Hasebroock KM, Serkova NJ. (2009). Toxicity of MRI and CT contrast agents. Expert Opin Drug Metab Toxicol 5:403–416
  • Lagroye I, Poncy JL. (1997). The effect of 50-Hz electromagnetic fields on the formation of micronuclei in rodent cell lines exposed to gamma radiation. Int J Radiat Biol 72:249–254
  • Lee BC, Johng HM, Lim JK, et al. (2004). Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study. J Photochem Photobiol B 73:43–48
  • Liu H, Yuan L, Yang X, Wang K. (2003). La(3+), Gd(3+) and Yb(3+) induced changes in mitochondrial structure, membrane permeability, cytochrome c release and intracellular ROS level. Chem Biol Interact 146:27–37
  • Loscher W, Mevissen M. (1994). Animal studies on the role of 50/60-Hertz magnetic fields in carcinogenesis. Life Sci 54:1531–1543
  • Luo J, Shi R. (2005). Acrolein induces oxidative stress in brain mitochondria. Neurochem Int 46:243–252
  • Lupke M, Rollwitz J, Simko M. (2004). Cell activating capacity of 50 Hz magnetic fields to release reactive oxygen intermediates in human umbilical cord blood-derived monocytes and in Mono Mac 6 cells. Free Radic Res 38:985–993
  • Marckmann P, Skov L, Rossen K, et al. (2006). Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging. J Am Soc Nephrol: JASN 17:2359–2362
  • Mevissen M, Haussler M, Lerchl A, Loscher W. (1998). Acceleration of mammary tumorigenesis by exposure of 7,12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100-microT magnetic field: replication study. J Toxicol Environ Health A 53:401–418
  • Perazella MA. (2008). Tissue deposition of gadolinium and development of NSF: a convergence of factors. Semin Dial 21:150–154
  • Perazella MA, Rodby RA. (2007). Gadolinium use in patients with kidney disease: a cause for concern. Semin Dial 20:179–185
  • Ray DE, Cavanagh JB, Nolan CC, Williams SC. (1996). Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats. AJNR Am J Neuroradiol 17:365–373
  • Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184–191
  • Takahashi M, Tsutsui H, Murayama C, et al. (1996). Neurotoxicity of gadolinium contrast agents for magnetic resonance imaging in rats with osmotically disrupted blood-brain barrier. Magn Reson Imaging 14:619–623
  • Toney GM, Chavez HA, Ibarra R, Jinkins JR. (2001). Acute and subacute physiological and histological studies of the central nervous system after intrathecal gadolinium injection in the anesthetized rat. Invest Radiol 36:33–40
  • Toritsuka N, Daimon H, Sawada S, et al. (1999a). Mutagenicity study of gadobenate dimeglumine formulation (E7155) (2)–Chromosome aberration test with human lymphocytes in culture. J Toxicol Sci 24:95–101
  • Toritsuka N, Daimon H, Sawada S, et al. (1999b). Mutagenicity study of gadobenate dimeglumine formulation (E7155) (3)–Micronucleus test in rat bone marrow cells. J Toxicol Sci 24:103–106
  • Trattnig S, Mlynarik V, Breitenseher M, et al. (1999). MRI visualization of proteoglycan depletion in articular cartilage via intravenous administration of Gd-DTPA. Magn Reson Imaging 17:577–583
  • Walleczek J, Shiu EC, Hahn GM. (1999). Increase in radiation-induced HPRT gene mutation frequency after nonthermal exposure to nonionizing 60 Hz electromagnetic fields. Radiat Res 151:489–497
  • WHO – World Health Organization. (2007). Extremely low frequency fields. Environmental Health Criteria 238. Geneva: World Health Organization
  • Xia Q, Feng X, Huang H, et al. (2011). Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons. J Neurochem 117:38–47
  • Yan G-P, Robinson L, Hogg P. (2007). Magnetic resonance imaging contrast agents: overview and perspectives. Radiography 13:e5–e19
  • Ye LH, Shi Z, Liu HX, et al. (2011). Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway. J Rare Earths 29:178–184
  • Yongxing W, Xiaorong W, Zichun H. (2000). Genotoxicity of lanthanum (III) and gadolinium (III) in human peripheral blood lymphocytes. Bull Environ Contam Toxicol 64:611–616

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.