References
- Aprikian O, Duclos V, Guyot S, et al. (2003). Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats. J Nutr 133:1860–1865
- Barth SW, Fähndrich C, Bub A, et al. (2005). Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 26:1414–1421
- Barth SW, Fähndrich C, Bub A, et al. (2007). Cloudy apple juice is more effective than apple polyphenols and an apple juice derived cloud fraction in a rat model of colon carcinogenesis. J Agric Food Chem 55:1181–1187
- Benson AM, Barretto PB, Stanley JS. (1986). Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice. J Natl Cancer Inst 76:467–473
- Bhattacharya P, Keating AF. (2012). Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity. Toxicol Appl Pharmacol 260:201–208
- Boyer J, Liu RH. (2004). Apple phytochemicals and their health benefits. Nutr J 3:1–15
- Burke MD, Thompson S, Weaver RJ, et al. (1994). Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem Pharmacol 4:923–936
- Coles B, Ketterer B. (1999). The role of glutathione transferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol 25:47–70
- Collins AR. (2004). The comet assay for DNA damage and repair: principles, applications and limitations. Mol Biotech 26: 249–261
- Diwan BA, Henneman JR, Rice JM, Nims RW. (1996). Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B. Carcinogenesis 17:37–43
- Ernster L. (1967). DT-diaphorase. Methods Enzymol 10:309–317
- Gerhauser C. (2008). Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med 74:1608–1624
- Girolami F, Abbadessa G, Racca S, et al. (2008). Time-dependent acetylsalicylic acid effects on liver CYP1A and antioxidant enzymes in rat model of 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis. Toxicol Lett 181:87–92
- Gossé F, Guyot S, Roussi S, et al. (2005). Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 26:1291–1295
- Habig WH, Pabs MJ, Jacoby WB. (1974). Glutathione S-transferse. The first enzymatic steps in mercapturic acid formation. J Biol Chem 249:7130–7139
- Han EH, Hwang YO, Jeong TC, et al. (2007). Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase. FEBS Lett 581:749–756
- Hartmann A, Agurell E, Beevers C, et al. (2003). Recommendations for conducting the in vivo alkaline Comet assay. Mutagenesis 8:45–51
- Henderson CJ, Smith AG, Ure J, et al. (1998). Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci USA 95:5275–5280
- Hyson DA. (2011). A comprehensive review of apples and apple components and their relationship to human health. Adv Nutr 2:408–420
- Jung KJ, Wallig MA, Singletary KW. (2006). Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 233:279–288
- Keum YS, Han YH, Liew C, et al. (2006). Induction of heme oxygenase-1 (HO-1) and NAD[P]H:quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-buthylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharm Res 23:2586–2594
- Krajka-Kuźniak V, Kaczmarek J, Baer-Dubowska W. (2008). Effect of naturally occurring phenolic acids on the expression of glutatione S-transferase isozymes in the rat. Food Chem Toxicol 46:1097–1102
- Krajka-Kuźniak V, Paluszczak J, Celewicz L, et al. (2013). Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes. Food Chem Toxicol 51:202–209
- Krajka-Kuźniak V, Szaefer H, Baer-Dubowska W. (2004). Modulation of 3-methylcholanthrene-induced rat hepatic and renal cytochrome P450 and phase II enzymes by plant phenols: protocatechuic and tannic acids. Toxicol Lett 152:117–126
- Kujawska M, Ignatowicz E, Ewertowska M, et al. (2011). Cloudy apple juice protects against chemical-induced oxidative stress in rat. Eur J Nutr 50:53–60
- Kujawska M, Ignatowicz E, Ewertowska M, et al. (2013). Attenuation of KBrO3-induced renal and hepatic toxicity by cloudy apple juice in rat. Phytother Res 27:1214–1219
- Laemmli UK. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685
- Lambard SE, Burnett AK, Wolf CR, Craft JA. (1991). The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro. Biochem Pharmacol 42:1529–1535
- Liu JR, Dong HW, Chen BQ, et al. (2009). Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat. J Agric Food Chem 57:297–304
- Liu RH, Liu J, Chen B. (2005). Apples prevent mammary tumors in rats. J Agric Food Chem 53:2341–2343
- Long DJ II, Waikel RL, Wang X-J, et al. (2001). NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]anthracene-induced carcinogenesis in mouse skin. J Nat Cancer Inst 93: 1166–1170
- Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
- Markowski J, Kołodziejczyk K, Król B, et al. (2007). Phenolic in apples and processed apple products. Pol J Food Nutr Sci 57:383–388
- Nijhoff WA, Groen GM, Peters WHM. (1993). Induction of rat hepatic and intestinal glutathione S-transferases and glutathione by dietary naturally occurring anticarcinogens. Inter J Oncol 3:1131–1139
- Oszmiański J, Wolniak M, Wojdyło A, Wawer I. (2007). Comparative study of polyphenolic content and antiradical activity of cloudy and clear apple juices. J Sci Food Agric 87:573–579
- Pohl C, Will F, Dietrich H, Schrenk D. (2006). Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols. J Agric Food Chem 54:10262–10268
- Schaefer S, Baum M, Eisenbrand G, et al. (2006). Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines. Mol Nutr Food Res 50:24–33
- Soyalan B, Minn J, Schmitz HJ, et al. (2011). Apple juice intervention modulates expression of ARE-dependent genes in rat colon and liver. Eur J Nutr 50:135–143
- Towbin H, Staehelin T, Gordon J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some application. Proc Natl Acad Sci USA 76:4350–4354
- Tsao R, Yang R. (2003). Optimization of a new mobile phase to know the complex and real polyphenolic composition: towards a total phenolic index using high-performance liquid chromatography. J Chromatogr A 1018:29–40
- Wattenberg LW. (1971). Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer: effect of diet on benzpyrene hydroxylase activity. Cancer 28:99–102
- Wilms LC, Boots AW, de Boer VC, et al. (2007). Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis 28:1800–1806
- Zessner H, Pan L, Will F, et al. (2008). Fractionation of polyphenol-enriched apple juice extracts to identify constituents with cancer chemopreventive potential. Mol Nutr Food Res 52:S28–S44