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Research Article

Protective effects of silymarin on epirubicin-induced mucosal barrier injury of the gastrointestinal tract

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Pages 442-451 | Received 16 Apr 2014, Accepted 23 Nov 2014, Published online: 22 Jan 2015

References

  • Abascal K, Yarnell E. (2003). The many faces of Silybum marianum (Milk Thistle). Alternat Complement Ther 9:251–256
  • Ahmad I, Shuka S, Kumar A, et al. (2013). Biochemical and molecular mechanisms of N-acetyl cysteine and sylimarin-mediated protection against maneb- and paraquat induced hepatotoxicity in rats. Chem Biol Interact 201:9–18
  • Al-Dasooqi N, Sonis ST, Bowen JM, et al. (2013). Emerging evidence on the pathobiology of mucositis. Support Care Cancer 21:3233–3241
  • Alderton PM, Gross J, Green MD. (1992). Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model. Cancer Res 52:194–201
  • Barcelo A, Claustre J, Moro F, et al. (2000). Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon. Gut 46:218–224
  • Bowen J, Gibson R, Keefe DM, Cummings AG. (2005). Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans. Pathology 37:56–62
  • Bowen JM, Gibson RJ. (2006). Cummins Dorothy M. K. Keefe, Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer 14:713–731
  • Buschini A, Poli P, Rossi C. (2003). Saccharomyces cerevisiae as an eukaryotic cell model to assess cytotoxicity and genotoxicity of three anticancer anthraquinones. Mutagenesis 18:25–36
  • Carneiro-Filho BA, Oriá RB, Wood Rea K, et al. (2004). Alanyl-glutamine hastens morphologic recovery from 5-fluorouracil-induced mucositis in mice. Nutrition 20:934–941
  • Cawley MM, Benson LM. (2005). Current trends in managing oral mucositis. Clin J Oncol Nurs 9:584–592
  • Charak S, Jangir DK, Tyagi G, Mehrotra R. (2011). Interaction studies of Epirubicin with DNA using spectroscopic techniques. J Cryst Mol Struct 1000:150–154
  • Chung-Ta C, Tin-Yun H, Ho L, et al. (2012). 5-Fluorouracil induced intestinal mucositis via nuclear factor-kB activation by transcriptomic analysis and in vivo bioluminescence imaging. PLoS One 7:e31808
  • Esmaily H, Vaziri-Bami A, Miroliae AE, et al. (2011). The correlation between NF-jB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis. Fundam Clin Pharm 25:723–733
  • Gaurav K, Goel RK, Shukla M, Pandey M. (2012). Glutamine: a novel approach to chemotherapy-induced toxicity. Indian J Med Paediatr Oncol 33:13–20
  • Gibson R. (2007). Establishment of a single-dose irinotecan model of gastrointestinal mucositis. Chemotherapy 53:360–369
  • Gibson R, Bowen J, Keefe D. (2008). Technological advances in mucositis research: new insights and new issues. Cancer Treat Rev 34:476–482
  • Girish C, Koner B, Jaianthy S, et al. (2009). Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharm 23:735–745
  • Greenle H, Abscal K, Yarnell E, Ladas E. (2007). Clinical applications of Silybum marianum in oncology. Integr Cancer Ther 6:158–165
  • Jain A, Yadav A, Bozhkov AI, et al. (2011). Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats. Ecotox Environ Safe 74:607–614
  • Jensen SB, Mouridsen HT, Bergmann OJ, et al. (2008). Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:217–226
  • Jiang Y, Wang H, Jing Wang J, et al. (2009). The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells. J Pharmacol Sci 111:137–146
  • Kaczmarek A, Brinkman BM, Heyndrickx L, et al. (2012). Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways. J Pathol 226:598–608
  • Kanareka N, Grivennikovb SI, Leshetsa M, et al. (2014). Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci USA 111:E702–E711
  • Kaya A, Coskun U, Buyukberber S, et al. (2010). Efficacy and toxicity of preoperative chemotherapy with docetaxel and epirubicin in locally advanced invasive breast cancer. J Buon 15:248–254
  • Keefe DM, Schubert MM, Elting LS, et al. (2007). Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820–831
  • Kerr J, Winterford C, Harmon B. (1994). Apoptosis: its significant in cancer and cancer therapy. Cancer 73:2013–2026
  • Komarova EA, Gudkov AV. (2000). Suppresion of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry 65:657–667
  • Komarova EA, Gudkov AV. (2001). Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors. Biochem Pharmacol 62:657–667
  • Komarova EA, Neznanov N, Komarov PG, et al. (2003). p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278:15465–15468
  • Kshirsagar A, Ingawale D, Ashok P, Vyawahare N. (2009). Silymarin: a comprehensive review. Phcog Rev 3:126–134
  • Logan RM, Gibson RJ, Sonis ST. (2007). Nuclear factor-kappaB (NF-kappaB) and cycloxygenase-2 (COX-2) expression in oral mucosa following cancer chemotherapy. Oral Oncol 43:395–401
  • Loo W, Jin LJ, Chow L, et al. (2010). Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients. Expert Opin Investig Drugs 19:S91–S100
  • Merritt AJ, Potten CS, Watson AJ, et al. (1995). Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 108:2261–2271
  • Morelli D, Menard S, Colnaghi MI. (1996). Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice. Cancer Res 56:2082–2085
  • Olinski R, Jaruga P, Foksinski M, et al. (1997). Epirubicin-induced oxidative DNA damage and evidence for its repair in lymphocytes of cancer patients who are undergoing chemotherapy. Mol Pharmacol 52:882–885
  • Ozkan A, Fiskin K. (2004). Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. Pol J Pharmacol 56:435–444
  • Patel N, Joseph C, Corcoran GB, Ray SD. (2010). Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. Toxicol Appl Pharmacol 245:143–153
  • Peterson DE, Keefe DM, Hutchins RD, Schubert MM. (2006). Alimentary tract mucositis in cancer patients: impact of terminology and assessment on research and clinical practice. Support Care Cancer 14:499–504
  • Pritchard DM, Potten CS, Hickman JA. (1998). The relationship between p53-dependent apoptosis, inhibition of proliferation and 5-fluorouracil-induced histopathology in murine small intestinal epithelia. Cancer Res 58:5453–5465
  • Radko L, Cybulski W. (2007). Application of silymarin in human and animal medicine. J Pre-Clin Clin Res 1:022–026
  • Raskovic A, Stilinovic N, Kolarovic J, et al. (2011). The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules 16:8601–8613
  • Rooseboom A, Commandeur J, Vermeulen N. (2004). Enzyme-catalyzed activation of anticancer prodrugs. Pharmacol Rev 56:53–102
  • Ruemmele FM, Russo P, Beaulieu J, et al. (1999). Susceptibility to FAS-induced apoptosis in human non-tumoral enterocytes the role of co-stimulatory factors. J Cell Physiol 181:45–54
  • Sonis ST. (2004). The pathobiology of mucositis. Nat Rev Cancer 4:277–284
  • Sonis ST. (2010). New thoughts on the initiation of mucositis. Oral Dis 16:597–600
  • Sonis ST. (2011). Oral mucositis. Anti-Cancer Drugs 22:607–612
  • Sonis S, Keefe DM. (2013). Pathobiology of cancer regimen-related toxicities. New York: Springer Science+Business Media
  • Stringer AM, Gibson RJ, Bowen JM, et al. (2007). Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment. J Support Oncol 5:259–267
  • Sun Z, Wang X, Wallen R, et al. (1998). The influence of apoptosis on intestinal barrier integrity in rats. Scand J Gastroenterol 33:415–422
  • Sung L, Tomlinson GA, Greenberg ML, et al. (2007). Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur J Cancer 43:1269–1275
  • Tunca R, Sozmen M, Citil M, et al; Pyridine induction of cytochrome P4501A1. (2009). iNOS and metallothionein in Syrian hamsters and protective effects of silymarin. Exp Toxicol Pathol 61:243–255
  • Upadhyay G, Singh AK, Kumar A, et al. (2008). Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress. Eur J Pharmacol 596:146–152
  • van’t Land B, van Beek NM, van den Berg JJ, M’Rabet L. (2004). Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation. Dig Dis Sci 49:425–433
  • Yeoh A, Gibson R, Yeoh E, et al. (2006). Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2. Cancer Treat Review 32:645–651

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