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Research Article

Assessment of in vitro genotoxic and cytotoxic effects of flurbiprofen on human cultured lymphocytes

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Pages 338-343 | Received 18 Jun 2015, Accepted 13 Nov 2015, Published online: 07 Jan 2016

References

  • Albertini RJ, Anderson D, Douglas GR, et al. (2000). IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. Mutat Res 463:111–172
  • Andrews P, Zhao X, Allen J, et al. (2008). A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. Cancer Chemother Pharmacol 61:203–214
  • Battisti N. (1994). The evaluation of the analgesic and anti-inflammatory effects of flurbiprofen mouthwash and 100-mg tablets in oral medicine. Minerva Stomatol 43:141–144
  • Bock JM, Menon SG, Goswami PC, et al. (2007). Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition. Mol Carcinog 46:857–864
  • Brambilla G, Martelli A. (2009). Genotoxicity and carcinogenicity studies of analgesics, anti-inflammatory drugs and antipyretics. Pharmacol Res 60:1–17
  • Endo H, Yano M, Okumura Y, Kido H. (2014). Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70. Cell Death Dis 5:e1027
  • Escarcega RO, Fuentes-Alexandro S, Garcia-Carrasco M, et al. (2007). The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol) 19:154–161
  • Falfushynska HI, Gnatyshyna LL, Osadchuk OY, et al. (2014). Diversity of the molecular responses to separate wastewater effluents in freshwater mussels. Comp Biochem Physiol C Toxicol Pharmacol 164:51–58
  • Fang JY, Hwang TL, Fang CL, Chiu HC. (2003). In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int J Pharm 255:153–166
  • Fenech M. (2000). The in vitro micronucleus technique. Mutat Res 455:81–95
  • Fratelli M, Minto M, Crespi A, et al. (2003). Inhibition of nuclear factor-kappaB by a nitro-derivative of flurbiprofen: a possible mechanism for antiinflammatory and antiproliferative effect. Antioxid Redox Signal 5:229–235
  • Fu H, Chen H, Wang C, et al. (2012). Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3β signaling and mitochondrial permeability transition. Mol Med 18:1128–1135
  • Grosch S, Schilling K, Janssen A, et al. (2005). Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. Biochem Pharmacol 69:831–839
  • Hoferova Z, Soucek K, Hofmanova J, et al. (2004). In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase. Cancer Invest 22:234–247
  • Jaju M, Jaju M, Ahuja YR. (1984). Evaluation of genotoxicity of ampicillin and carbenicillin on human lymphocytes in vitro: chromosome aberrations, mitotic index, cell cycle kinetics, satellite associations of acrocentric chromosomes and sister chromatid exchanges. Hum Toxicol 3:173–191
  • Jin H, Wang Z, Liu L, et al. (2010). R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. Mol Pharm 7:156–168
  • Jurima-Romet M, Crawford K, Huang HS. (1994). Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes. Toxicol in Vitro 8:55–66
  • Kawadkar J, Pathak A, Kishore R, Chauhan MK. (2013). Formulation, characterization and in vitro-in vivo evaluation of flurbiprofen-loaded nanostructured lipid carriers for transdermal delivery. Drug Dev Ind Pharm 39:569–578
  • Khwaja F, Allen J, Lynch J, et al. (2004). Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res 64:6207–6213
  • Kim KS, Yoon JH, Kim JK, et al. (2004). Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys Res Commun 325:1298–1303
  • Koga T, Fujiwara R, Nakajima M, Yokoi T. (2011). Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes. Drug Metab Dispos 39:54–60
  • Koseoglu BG, Ozturk S, Kocak H, et al. (2008). The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery. Yonsei Med J 49:742–747
  • Kullich W, Klein G. (1986). Investigations of the influence of nonsteroidal antirheumatic drugs on the rates of sister-chromatid exchange. Mutat Res 174:131–134
  • Kusuhara H, Komatsu H, Sumichika H, Sugahara K. (1999). Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. Eur J Pharmacol 383:331–337
  • Liu JK, Patel SK, Gillespie DL, et al. (2012). R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. J Neurooncol 106:561–569
  • Martin JE, Young GP, LE Leu RK, Hu Y. (2013). Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer model. Anticancer Res 33:3581–3588
  • Masubuchi Y, Saito H, Horie T. (1998). Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther 287:208–213
  • Nath N, Liu X, Jacobs L, Kashfi K. (2013). Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin. Drug Des Devel Ther 7:389–396
  • OECD. (1997). Test No. 473: in vitro mammalian chromosome aberration test. Paris: OECD Publishing
  • Oldham JW, Preston RF, Paulson JD. (1986). Mutagenicity testing of selected analgesics in Ames Salmonella strains. J Appl Toxicol 6:237–243
  • Philipose B, Singh R, Khan KA, Giri AK. (1997). Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen. Mutat Res 393:123–131
  • Quann EJ, Khwaja F, Zavitz KH, Djakiew D. (2007). The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res 67:3254–3262
  • Rakesh KS, Jagadish S, Vinayaka AC, et al. (2014). A new ibuprofen derivative inhibits platelet aggregation and ROS mediated platelet apoptosis. PLoS One 9:e107182
  • Rothfuss A, Schutz P, Bochum S, et al. (2000). Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60:390–394
  • Sheikh MS, Huang Y. (2003). The FADD is going nuclear. Cell Cycle 2:346–347
  • Speit G, Haupter S. (1985). On the mechanism of differential Giemsa staining of bromodeoxyuridine-substituted chromosomes. II. Differences between the demonstration of sister chromatid differentiation and replication patterns. Hum Genet 70:126–129
  • Sun Y, Huang L, Mackenzie GG, Rigas B. (2011). Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. J Pharmacol Exp Ther 338:775–783
  • Tegeder I, Niederberger E, Israr E, et al. (2001). Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. FASEB J 15:595–597
  • Tewari AK, Srivastava P, Singh VP, et al. (2010). Novel anti-inflammatory agents based on pyrazole based dimeric compounds; design, synthesis, docking and in vivo activity. Chem Pharm Bull (Tokyo) 58:634–638
  • Tripathi R, Pancholi SS, Tripathi P. (2012). Genotoxicity of ibuprofen in mouse bone marrow cells in vivo. Drug Chem Toxicol 35:389–392
  • Watson N, Nimmo WS, Christian J, et al. (2000). Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 54:490–496
  • Wechter WJ, Leipold DD, Murray ED, Jr, et al. (2000). E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse. Cancer Res 60:2203–2208
  • Williams GM, Mori H, McQueen CA. (1989). Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals. Mutat Res 221:263–286
  • Zhao X, Rebeck GW, Hoe HS, Andrews PM. (2008). Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins. J Alzheimers Dis 15:397–407
  • Zielinska-Przyjemska M, Glowka FK, Klaczynska J. (2008). Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils. Chirality 20:159–165

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