Advanced search
Publication Cover
Drug and Chemical Toxicology Volume 39, 2016 - Issue 4
Submit an article Journal homepage
104
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Quercetin and vitamin E attenuate Bonny Light crude oil-induced alterations in testicular apoptosis, stress proteins and steroidogenic acute regulatory protein in Wistar rats

Azubuike P. EbokaiweDepartment of Chemistry/Biochemistry and Molecular Biology, Federal University Ndufu-Alike Ikwo, Ebonyi, Nigeria, Correspondence[email protected]
,
Premendu P. MathurReproductive & Endocrine Biochemistry Research Laboratories, Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, India, and
&
Ebenezer O. FarombiDrug Metabolism & Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Pages 424-431 | Received 01 Jul 2015, Accepted 28 Dec 2015, Published online: 28 Jan 2016

References

  • Abarikwu SO, Farombi EO. (2014). Quercetin ameliorates atrazine-induced changes in the testicular function of rats. Toxicol Ind Health 3:1701–1715.
  • Adedara IA, Ebokaiwe AP, Mathur PP, Farombi EO. (2014). Nigerian bonny light crude oil induces endocrine disruption in male rats. Drug Chem Toxicol 37:198–203.
  • Adedara IA, Teberen R, Ebokaiwe AP, et al. (2012). Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil. Environ Toxicol 27:372–379.
  • Ahmad A, Khan MM, Hoda MN, et al. (2011). Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion. Neurochem Res 36:1360–1371.
  • CPCSEA. (2003). CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol 35:257–274.
  • Ebokaiwe AP, Adedara IA, Owoeye O, Farombi EO. (2013). Neurotoxicity of Nigerian bonny light crude oil in rats. Drug Chem Toxicol 36:187–195.
  • Ebokaiwe AP, D’Cruz CS, Jubendradass R, et al. (2015a). Nigerian bonny-light crude oil induces alteration in testicular stress response proteins and caspase-3 dependent apoptosis in albino Wistar rats. Environ Toxicol 30:242–252.
  • Ebokaiwe AP, Farombi EO. (2015). Influence of vitamin E and quercetin on Nigerian Bonny Light crude oil-induced neuronal and testicular toxicity in Wistar rats. J Basic Clin Physiol Pharmacol 26:223–231.
  • Ebokaiwe AP, Ramesh P, Mathur PP, Farombi EO. (2015b). Transient effect of single dose exposure of Nigerian Bonny-light crude oil on testicular steroidogenesis in Wistar rats is accompanied by oxidative stress. Drug Chem Toxicol 38:428–435.
  • Farombi EO, Adedara IA, Ebokaiwe AP, et al. (2010). Nigerian Bonny light crude oil disrupts antioxidant systems in testes and sperm of rats. Arch Environ Contam Toxicol 59:166–174.
  • Fukushima T, Yamamoto T, Kikkawa R, et al. (2005). Effects of male reproductive toxicants on gene expression in rat testes. J Toxicol Sci 30:195–206.
  • Grundman M. (2000). Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr 71:630S–636S.
  • Kaur P, Kaur G, Bansal MP. (2006). Tertiary-butyl hydroperoxide induced oxidative stress and male reproductive activity in mice: role of transcription factor NF-kappaB and testicular antioxidant enzymes. Reprod Toxicol 22:479–484.
  • Kreuz S, Siegmund D, Rumpf JJ, et al. (2004). NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J Cell Biol 166:369–380.
  • Laemmli UK. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685.
  • Liu CM, Zheng YL, Lu J, et al. (2010). Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environ Toxicol Pharmacol 29:158–166.
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265.
  • Mathur PP, Huang L, Kashou A, et al. (2011). Environmental toxicants and testicular apoptosis. Open Reprod Sci J 3:114–124.
  • Renugadevi J, Prabu SM. (2010). Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol 62:471–481.
  • Sahoo DK. (2013). Testicular protection from thyroid hormone mediated oxidative stress. Reproduction 4:WMC004252.
  • Saradha B, Mathur PP. (2006). Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol 21:34–41.
  • Saradha B, Vaithinathan S, Mathur PP. (2009). Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria dependent pathways. Toxicology 255:131–139.
  • Trougakos IP, Gonos ES. (2006). Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res 40:1324–1334.
  • Vaithinathan S, Saradha B, Mathur PP. (2008). Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study. Arch Toxicol 82:833–839.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.