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Research Article

l-carnitine protects rat hepatocytes from oxidative stress induced by T-2 toxin

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Pages 445-450 | Received 10 Aug 2015, Accepted 10 Jan 2016, Published online: 18 Feb 2016

References

  • Albano E. (2008). Oxidative mechanism in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29:9–16
  • Bouaziz C, Dein OSE, Golli EE, et al. (2008). Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells. Toxicology 254:19–28
  • Chaudhari M, Jayaraj R, Bhaskar ASB, Rao PVL. (2009). Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology 262:153–161
  • Chaudhary M, RAO PVL. (2010). Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice. Food Chem Toxicol 48:3436–3442
  • Doi K, Ishigami N, Sehata S. (2008). T-2 toxin-induced toxicity in pregnant mice and rats. Int J Mol Sci 9:2146–2158
  • Ellman GL, Courtney KD, Valentino Andres J, Featherstone RM. (1960). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95
  • Fang H, Wu Y, Guo J, et al. (2012). T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway. Apoptosis 17:895–907
  • Gaigé S, Djelloul M, Tardivel C, et al. (2014). Modification of energy balance induced by the food contaminant T-2 toxin: a multimodal gut-to-brain connection. Brain Behav Immun 37:54–72
  • Garcia CL, Filippi S, Mosesso P, et al. (2006). The protective effect of L-carnitine in peripheral blood human lymphocytes exposed to oxidative agents. Mutagenesis 21:21–27
  • He MD, Xu SC, Lu YH, et al. (2011). L-carnitine protects against nickel-induced neurotoxicity by maintaining mitochondrial function in Neuoro-2a cells. Toxicol Appl Pharmacol 253:38–44
  • Izgüt-Uysal VN, Agaç A, Karadogan I, Derin N. (2004). Peritoneal macrophages function modulation by L-carnitine in aging rats. Aging Clin Exp Res 16:337–341
  • Josse L, Li X, D.Coker R, et al. (2011). Transcriptomic and phenotypic analysis of the effects of T-2 toxin on Saccharomyces cerevisiae: evidence of mitochondrial involvement. FEMS Yeast Res 11:133–150
  • Li JL, Wang QY, Luan HY, et al. (2012). Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha. J Biomed Sci 19:32
  • Liu J, Wang L, Guo X, et al. (2014). The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis. PLoS One 9:e108394
  • Mansour HH. (2006). Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res 54:165–171
  • Minervini F, Fornelli F, Lucivero G, et al. (2005). T-2 toxin immunotoxicity on human B and T lymphoid cell lines. Toxicology 210:81–91
  • Oyanagi E, Yano H, Uchida M, et al. (2011). Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acid stress. Biochem Biophys Res Commun 412:61–67
  • Oyanagi E, Yano H, Y Kato EA. (2008). L-carnitine suppresses oleic acid-induced membrane permeability transition of mitochondria. Cell Biochem Funct 26:778–786
  • Pourahmad J, O’Brien PJ. (2000). A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+. Toxicology 143:263–273
  • Ravindran J, Agrawal M, Gupta N, Lakshmana Rao PV. (2011). Alteration of blood brain barrier permeability by T-2 toxin: role of MMP-9 and inflammatory cytokines. Toxicology 280:44–52
  • Rezaei M, Rasekh HR, Ahmadiani A, Pourahmad J. (2008). Involvement of subcellular organelles in inflammatory pain-induced oxidative stress and apoptosis in the rat hepatocytes. Arch Iran Med 11:407–417
  • Rezaei M, Salimi A, Taghidoost M, et al. (2014). A comparison of toxicity mechanisms of dust storm particles collected in the southwest of Iran on lung and skin using isolated mitochondria. Toxicol Environ Chem 96:1–17
  • Riazipour M, Fooladi AAI, Bagherpour G. (2012). Survey of T-2 toxin present in cereals destined for human consumption. Jundishapur J Microbiol 5:497–501
  • Riazipour M, Fooladi AI, Razzaghi-Abyaneh M. (2009). Natural occurrence of T-2 toxin in domestic and imported rice. Iran J Publ Health 38:111–116
  • Savitha S, Panneerselvam C. (2006). Mitochondrial membrane damage during aging process in rat heart: potential efficacy of l-carnitine and dl alpha lipoic acid. Mech Ageing Dev 127:349–355
  • Singh NP. (2000). A simple method for accurate estimation of apoptotic cells. Exp Cell Res 256:328–337
  • Singh NP. (2005). Apoptosis assessment by the DNA diffusion assay. Methods Mol Med 111:55–67
  • Sue Y, Chou H, Chang C, et al. (2014). L-carnitine protects against carboplatin-mediated renal injury: AMPK- and PPARa-dependent inactivation of NFAT3. PLoS One 9:1–12
  • Tice RR, Agurell E, Anderson D, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206–221
  • Vescovo G, Ravara B, Gobbo V, et al. (2002). l-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure. Am J Physiol Cell Physiol 283:C802–C810. DOI: 10.1152/ajpcell.00046.2002
  • Virmani A, Binienda Z. (2004). Role of carnitine esters in brain neuropathology. Mol Aspects Med 25:533–549
  • Wu J, Tu D, Yuan LY, et al. (2015). T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway. Toxicol Lett 232:573–579
  • Wu QH, Wang X, Yang W, et al. (2014). Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Arch Toxicol 88:1309–1326
  • Xiang Y, Piao SG, Zou HB, et al. (2013). L-carnitine protects against cyclosporine-induced pancreatic and renal injury in rats. Transplant Proc 45:3127–3134
  • Yapar K, Kart A, Karapehlivan M, et al. (2007). Hepatoprotective effect of l-carnitine against acute acetaminophen toxicity in mice. Exp Toxicol Pathol 59:121–128
  • Yuan G, Wang Y, Yuan X, et al. (2014). T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos. J Environ Sci 26:917–925
  • Zhuang Z, Yang D, Huang Y, Wang S. (2013). study on the apoptosis mechanism induced by T-2 Toxin. PLoS One 8:e83105

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