15
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Acute and Subchronic Toxicity of the Protease Inhibitor N-α-Tosyl-L-Lysyl-Chloromethylketone (TLCK) in Mice

Pages 227-235 | Published online: 27 Sep 2008

References

  • Goetz I. E., Weinstein C., Roberts E. Effect of protease inhibitors on growth of hamster tumor cells in culture. Cancer Res. (1972); 32: 2469
  • Wever M. J. Inhibition of protease activity in cultures of Rous sarcoma virus‐transformed cells: Effect on the transformed phenotype. Cell (1975); 5: 253
  • Baker M. E., Fanestil D. D. Effect of protease inhibitors and substrates on deoxycorticosterone binding to its receptor in dog MDCK kidney cells. Nature (1977); 269: 810
  • Troll W., Klassen A., Janoff A. Tumorigenesis in mouse skin: Inhibition by synthetic inhibitors of proteases. Science (1970); 169: 1211
  • Rickert N., Davies P. J.A., Jay G., Pastan I. Inhibition of the transformation‐specific kinase in ASV transformed cells by N‐α‐tosyl‐L‐lysyl‐chloromethylketone. Cell (1979); 18: 369
  • Finney D. J. Probit Analysis2nd edit. Cambridge University Press. 1951
  • O'Neil J. D., Brown D. J., Forney R. B. A new approach to an old method—a BASIC program for the calculation of the ED50 or LD50 using probit analysis. Tox. appl. Pharmacol. (1979); 48: A102
  • Gleason M. N., Gosselin R. E., Hodge H. C., Smith M. C. Clinical Toxicology of Commercial Products2nd edit. Williams and Wilkins, Baltimore 1972
  • Rossman T., Norris C., Troll W. Inhibition of macromolecule synthesis in E. coli by protease inhibitors: Specific reversal by glutathione of the effects of chloromethylketones. J. biol. Chem. (1974); 249: 3413
  • Smith H. J. Perspectives in the design of small molecule enzyme inhibitors as useful drugs. J. Theor. Biol. (1978); 73: 531

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.