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Drug and Chemical Toxicology Volume 15, 1992 - Issue 4
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Research Article

Successful Pretreatment/Therapy of Soman, Sarin and Vx Intoxication

W. J. Lennox U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, MD, 21010-5425
,
L. W. Harris U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, MD, 21010-5425
,
D. R. Anderson U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, MD, 21010-5425
,
R. P. Solana U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, MD, 21010-5425
,
M. L. Murrow U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, MD, 21010-5425
&
J. V. Wade U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, MD, 21010-5425
Pages 271-283 | Published online: 27 Sep 2008

References

  • Fonnum F., Guttormsen D. M. Changes in acetylcholine content of rat brain by toxic doses of diisopropylphosphorofluoridate. Experientia (1969); 25: 305
  • Harris L. W., Heyl W. C., Stitcher D. L., Moore R. D. Effect of atropine and/or physostigmine on cerebral acetylcholine in rats poisoned with soman. Life Sci. (1978); 22: 907
  • Lennox W. J., Harris L. W., Talbot B. G., Anderson D. R. Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality. Life Sci. (1985); 37: 793
  • Wolthuis O. L., Berends F., Meeter E. Problems in the therapy of soman poisoning. Fund. Appl. Toxicol. (1981); 1: 183
  • Fleisher J. H., Harris L. W. Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolyl methylphosphonofluoridate. Biochem Pharmacol (1965); 14: 641
  • Berry W. K., Davies D. R. The use of carbamates and atropine in the protection of animals against poisoning by 1,2,2,-trimethylpropyl methylphosphonofluoridate. Biochem. Pharmacol. (1970); 19: 927
  • Leadbeater L., Inns R. H., Rylands J. M. Treatment of poisoning by soman. Fund. Appl. Toxicol. (1985); 5: S225
  • Harris L. W., McDonough J. H., Jr., Stitcher D. L., Monroe F. L. Protection against both lethal and behavioral effects of soman. The Pharmacologist (1980); 22: 239
  • Harris L. W., Stitcher D. L., Heyl W. C. The effects of pretreatments with carbamates, atropine and mecamylamine on survival and on soman-induced alterations in rat and rabbit brain acetylcholine. Life Sci. (1980); 26: 1885
  • Harris L. W., McDonough J. H., Jr., Stitcher D. L., Lennox W. J. Protection against both lethal and behavioral effects of soman. Drug Chem. Toxicol. (1984); 7: 605
  • Harris L. W., Talbot B. G., Lennox W. J., Anderson D. R., Solana R. P. Physostigmine (alone and together with adjunct) pretreatment against soman, sarin tabun and VX intoxication. Drug Chem. Toxicol. (1991); 14: 265
  • Mays M. Z., McDonough J. H., Jr., Modrow H., Murrow M., Alvarez R., McCreesh D. Performance on a one-way avoidance conditioning task following nerve agent intoxication. Fifth Ann. Chem. Def. Biosci. Rev. Johns Hopkins Appl. Physics Lab., Columbia, MD 1985
  • AVMA Panel on Euthanasia. 1986 Report. JAVMA (1986); 188(No. 3)252–268
  • Natrella M. G. Experimental Statistics. Handbook 91. National Bureau of Standards, Washington, DC (1966); T-59, Table A-29
  • Ibid. 8–16, and Table A-3, p T-4
  • Tate M. W., Clelland R. C. Nonparametric and Shortcut Statistics in the Social, Biological and Medical Sciences. Interstate Printers and Publishers, Inc., Danville, IL (1957); 53, and Table D, p 129
  • Carroll F. I., Abraham P., Parham K., Griffith R. C., Ahmad A., Richard M. M., Padilla F. N., Witkin J. M., Chiang P. K. 6-Methyl-6-azabicyclo[3.2.1]octan-3-ol 2,2-diphenylpropionate (Azaprophen), a highly potent antimuscarinic agent. J. Med. Chem. (1987); 30: 805
  • Albuquerque E. X., Akaike A., Shaw K. P., Rickett D. L. The interaction of anticholinesterase agents with the acetylcholine receptor-ion channel complex. Fund. Appl. Toxicol. (1984); 4: 527–533
  • Pascuzzo G. J., Akaike A., Maleque A., Shaw K. P., Aronstam R. S., Rickett D. L., Albuquerque E. X. The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. I. Agonist, desensitizing, and binding properties. Mol. Pharmacol. (1984); 25: 92–101
  • Akaike A., Lkeda S. R., Brookes N., Pascuzzo G. J., Rickett D. L., Albuquerque E. X. The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ion channel complex. II. Patch clamp studies. Mol. Pharmacol. (1984); 25: 102–112

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