Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 2, 1979 - Issue 4
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Original Article

1-(2,4-Dichlorobenzyl)-1 H-lndazole-3-Carboxylic Acid (DICA), an Exfoliative Antispermatogenic Agent in the Rat

Pages 353-363 | Received 30 Jan 1979, Published online: 09 Jul 2009

References

  • Bennett J B. Chemical Contraception. Columbia University Press, New York 1974; 133–170
  • Catanese B, Cioli V, DeMartino C, et al. A comparative study of serum and testicular concentrations of AF1312/TS (or 1-[(4-chloro-phenyl)methyl]- 1H-indazole-3-carboxylic acid) and diclondazolic acid (or 1-[(2,4-dichlorophenyl)-methyl]-1H-indazole-3-carboxylic acid) in rats. Pharmacol Res Commun 1978; 10: 261–269
  • Corsi G, Palazzo G, Germani C, et al. 1-Halobenzyl-1H-indazole-3-carboxyIic acids. A new class of antispermatogenic agents. J Med Chem 1976; 19: 778–783
  • Coulston F, Doughterty W J, LeFevre R, et al. Reversible inhibition of spermatogenesis in rats and monkeys with a new class of indazol-carboxylic acids. Exp Mol Pathol 1975; 23: 357–366
  • DeMartino C, Stefanini M, Agrestini A, et al. Antispermatogenic activity of 1-p-chloro-benzyl-lH-indazol-3-carboxylic acid (AF1312/TS) in rats III. A light and electron microscopic study after single oral doses. Exp Mol Pathol 1975; 23: 321–356
  • Ericsson R J. Chemosterilants. Control of Male Fertility, J J Sciarra, C Markland, J J Speidel. Harper & Row, Hagerstown, Md 1975; 262–269
  • Kiser T D, Milvae R A, Hafs H D, et al. Comparison of testosterone and androstenedione secretion in bulls given prostaglandin F2α or luteinizing hormone. J Anim Sci 1978; 46: 436–442
  • Lobl T J, Gunsalus G L, Musto N, et al (1979) Modulation of testicular, epididymal, and serum androgen binding protein (ABP) levels by three heterocyclic exfoliating antispermatogenic agents. Proc. fourth Annual Meeting, Amer. Soc. Andrology, Houston, TXUSA, March 13–16, 1979
  • Lobl T J, Mathews J. Effect of 1-(2,4-dichlorobenzyl)-indazole-3-carboxylic acid on sperm tails in rhesus monkeys. J Reprod Fertil 1978; 52: 275–278
  • Lobl T J, Porteus S E. Antispermatogenic effects of 5-aminoindazole in rats. J Reprod Fertil 1977; 50: 371–372
  • Silvestrini B, DeMartino C, Cioli V, et al (1977) Antispermatogenic activity of diclondazolic acid in rats. Paper presented at the Conference on Recent Progress in Andrology, L'Aquila, Italy, April 21–23, 1977, (Proceedings in press)

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