Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 7, 1981 - Issue 1
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Original Article

Effect of Medrogestone on Conversions of Pregnenolone and 17α-Hydroxypregnenolone in Rat Testis

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Pages 35-37 | Received 08 Sep 1980, Published online: 09 Jul 2009

References

  • Bullock LP, Gupta C, Bardin CW. A mechanism for the antiandrogenic action of medrogestone. Int J Androl 1978; 1: 32–42
  • Chubb C, Ewing LL. Steroid secretion by in vitro perfused testis: Inhibitors of testosterone biosynthesis. Am J Physiol 1979; 237(3)E239–E246
  • Deghenghi R, Revesz C, Gaudry RJ. New synthesis and structure activity relationship in the 17-alkylated progesterone series. J Med Chem 1963; 6: 301–304
  • Givner ML, Dvornik D. Inhibition of testosterone biosynthesis by medrogestone. Experientia 1972; 28: 1105–1106
  • Jagarinec N, Givner ML. Inhibition of testosterone metabolism by medrogestone in rat ventral prostate in vivo and in vitro. Arch Androl 1981; 7: 39–44
  • Krebs AH, Henseleit K. Untersuchungen ueber die Harnstoffbildung im Tierkoerper. Z Physiol Chem 1932; 210: 33–66
  • Larsson H, Stensson M. Effect of bis (p-Hydroxyphenyl)-cyclo-hexylidenemethane(F 6060) on the conversion of pregnenolone to δ43-ketosteroids in vitro. Acta Endocrinol 1967; 55: 673–684
  • Nishina T, Sakai Y, Kimura M. A specific method for the Determination of δ4-3-ketoste-roids with p-nitrophenylhydrazine. Steroids 1964; 4: 255–266
  • Paulson DF, Kane RD. Medrogestone: A prospective study in the pharmaceutical management of benign prostatic hyperplasia. J Urol 1975; 113: 811–815
  • Rangno RE, McLeod PJ, Ruedy J, Ogilvie RI. Treatment of benign prostatic hypertrophy with medrogestone. Clin Pharmacol Ther 1971; 12: 658–665
  • Revesz C, Chappel CI. Biological activity of medrogestone, a new orally active progestin. J Reprod Fertil 1966; 12: 473–487
  • Sufrin G, Coffey DS. A new model for studying the effect of drugs on prostatic growth. Invest Urol 1973; 11: 45–54

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