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Archives of Andrology
Journal of Reproductive Systems
Volume 21, 1988 - Issue 2
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Original Article

Effects of Gossypol on the Antioxidant Defense System of the Rat Testis

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Pages 59-70 | Received 22 Feb 1988, Published online: 09 Jul 2009

References

  • Adams R, Geissman T A., Edwards J D. Gossypol, a pigment of cottonseed. Chem Rev 1960; 60: 555–574
  • Blanco A. On the functional significance of LDHX. The Johns Hopkins Medical Journal 1980; 146: 231–235
  • Bendich A, Machlin L J., Scandurra O, Burton G W., Wayner D DM. The antioxidant role of vitamin C. Adv Free Radical Biol Med 1986; 2: 419–444
  • Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–254
  • Brawn K, Fridovich I. Superoxide radical and superoxide dismutases. Acta Physiol Scand (Suppl) 1980; 492: 9–18
  • Burton G W., Webb A, Ingold K U. A mild, rapid, and efficient method of lipid extraction for use in determining vitamin E/lipid ratios. Lipids 1985; 20: 29–39
  • Carr R S., Bally M B., Thomas P, Neff J M. Comparison of methods for determination of ascorbic acid in animal tissues. Anal Chem 1983; 55: 1229–1232
  • Chang M C., Gu Z, Saksena S K. Effects of gossypol on the fertility of male rats, hamsters and rabbits. Contraception 1980; 21: 461–469
  • Chongthammakun S, Ekavipat C, Sanitwongse B, Pavasuthipaisit K. Effects of gossypol on human and monkey sperm motility in vitro. Contraception 1986; 34: 323–331
  • Clark I A., Cowden W B., Nicholas H H. Free radical-induced pathology. Medic Res Rev 1985; 5: 297–332
  • Coulson P B., Snell R L., Parise C. Short term metabolic effects of the antifertility agent, gossypol, on various reproductive organs of male mice. Int J Androl 1980; 3: 507–518
  • DePeyster A, Quintanilha A, Packer L, Smith M T. Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. Biochem Biophys Res Comm 1984; 118: 573–579
  • Freeman B A., Crapo J D. Free radicals and tissue injury. Lab Invest 1982; 47: 412–426
  • Fridovich I. Oxygen radicals, hydrogen peroxide and oxygen toxicity. Free Radicals in Biology, W A. Pryor. Academic Press, New York 1976; 239–277
  • , Guide for the Care and Use of Laboratory Animals, DHEW Publication No. (NIH) 80–23 (1985Office of Science and Health Reports, DRR/NIH, Bethesda, MD 20205
  • Hadley M A., Lin Y C., Dym M. Effects of gossypol on the reproductive system of male rats. J Androl 1981; 2: 190–199
  • Halliwell B. Superoxide dismutase, catalase and glutathione peroxidase: Solutions to the problems of living with oxygen. New Phytol 1974; 73: 1075–1086
  • Halliwell B, Gutteridge J MC. Free Radicals in Biology and Medicine. Clarendon Press, Oxford 1985; 1–19
  • Kornberg A, Horecker B L. Glucose-6-phosphate dehydrogenase. Methods in Enzymology, S P. Colowick, N O. Kaplan. Academic Press, New York 1955; 323–328
  • Kramer C Y. Extension of multiple range tests to group means with unequal numbers of replications. Biometrics 1956; 12: 307–310
  • Liu G Z. Cottonseed oil for contraception. Adv Contracept Deliv Syst 1985; 1: 29–35
  • Liu Z Q., Liu G Z., Hei L S., Zhang R A., Yu C Z. Clinical trial of gossypol as a male antifertility agent. Symposium on Recent Advances in Fertility Regulation, C Chang, D Griffin, A Woolman. ATAR, Geneva 1981; 160–163
  • Lohr G W., Waller H D. Glucose-6-phosphate dehydrogenase. Methods of Enzymatic Analysis, H U. Bergmeyer. Academic Press, New York 1974; 636–643
  • Masters C, Pegg M, Crane D. On the multiplicity of the enzyme cataiase in mammalian liver. Mol Cell Biochem 1986; 70: 113–120
  • Maugh T H., II. Male “pill” blocks sperm enzyme. Science 1981; 212: 314
  • Merck Index, 9th Edition. Merck and Co. 1976; 588
  • Misra H P. Adrenochrome assay. CRC Handbook of Methods for Oxygen Radical Research, R A. Greenwald. CRC Press, Boca Raton, Florida 1985; 237–241
  • Nadakavukaren M J., Sorenson R H., Tone J N. Effect of gossypol on the ultrastructure of rat spermatozoa. Cell Tissue Res 1979; 204: 293–296
  • National Coordinating Group on Male Antifertility Agents. Gossypol—A new antifertility agent for males. Chin Med J (Engl) 1978; 4: 417–428
  • Oko R, Hrudka F. Segmental aplasia of the mitochondrial sheath and sequellae induced by gossypol in rat spermatozoa. Biol Reprod 1982; 26: 183–195
  • Racker E. Glutathione reductase. Methods in Enzymology, S P. Colowick, N O. Kaplan. Academic Press, New York 1955; vol. 2: 722–725
  • Ratsula K, Haukkamaa M, Wichmann K, Luukkainen T. Vaginal contraception with gossypol: A clinical study. Contraception 1983; 27: 571–576
  • Saksena S K., Salmonsen R, Lau I F., Chang M C. Gossypol: Its toxicological and endocrinological effects in male rabbits. Contraception 1981; 24: 203–214
  • Shandilya L, Clarkson T B., Adams M R., Lewis J C. Effects of gossypol on reproductive and endocrine functions of male cynomolgous monkeys. Biol Reprod 1982; 27: 241–252
  • Sies H, Akerboon T PM. Glutathione disulfide (GSSG) efflux from cells and tissues. Methods in Enzymology, L Packer. Academic Press, New York 1984; vol. 105: 445–451
  • Stephens D T., Critchlow L M., Hopkins D D. Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. J Reprod Fertil 1983; 69: 447–452
  • Storer G B. F luorometric determination of tocopherol in sheep plasma. Biochem Med 1974; 11: 71–80
  • Tappel A L. Glutathione peroxidase and hydroperoxides. Methods in Enzymology, S Fleischer, L Packer. Academic Press, New York 1978; vol. 52: 506–513
  • Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal Biochem 1969; 27: 502–522
  • Waller D P., Fong H HS, Cordell G A., Soejarto D D. Antifertility effects of gossypol and its impurities on male hamsters. Contraception 1981; 23: 653–659
  • Waller D P., Zaneveld L JD, Fong H HS. In vitro spermicidal activity of gossypol. Contraception 1980; 22: 183–187
  • Wong P YD, Qiu J P., Fu W O. Gossypol does not affect testicular fluid secretion in rats. Contraception 1984; 29: 471–477
  • Worthington Enzyme Manual. Worthington Biochemical Corporation, N J. Freehold, 1972; 41–42
  • Xue S P. Studies on the antifertility effect of gossypol, a new contraceptive for males. Symposium on Recent Advances in Fertility Regulation, C Chang, D Griffin, A Woolman. ATAR, Geneva 1981; 122–145
  • Zatuchni G I., Osborn C K. Gossypol: A possible male antifertility agent. Research Frontiers in Fertility Regulation, G I. Zatuchni. Northwestern University, Chicago, IL 1981; 1–15
  • Zhou L F., Lei H P. Recovery of fertility in rats after gossypol treatment. Symposium on Recent Advances in Fertility Regulation, C Chang, D Griffin, A Woolman. ATAR, Geneva 1981; 147–151

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