Saccadic premotor neurons in the brainstem: functional neuroanatomy and clinical implications

References

• Fuchs A F, Kaneko C RS, Scudder C A. Brainstem control of saccadic eye movements. Annu Rev Neurosci 1985; 8: 307–337
   PubMed Web of Science ®Google Scholar
• Hepp K, Henn V, Vilis T, Cohen B. Brainstem regions related to saccade generation. Rev Oculomot Res 1989; 3: 105–212
   PubMedGoogle Scholar
• Moschovakis A K, Highstein S M. The anatomy and physiology of primate neurons that control rapid eye movements. Annu Rev Neurosci 1994; 17: 465–488
   PubMedGoogle Scholar
• Robinson D A. Oculomotor control signals. Basic Mechanisms of Ocular Motility and Their Clinical Implications, G. Lennerstrand Baeh, P Yrita. Pergamon, Oxford 1975; 337–374
   Google Scholar
• Scudder C A. A new local feedback model of the saccadic burst generator. J Neurophysiol 1988; 59: 1455–1475
   PubMed Web of Science ®Google Scholar
• Kaneko C RS. Tests of two models of the neural saccade generator: saccadic eye movement deficits following lesions of the nuclei raphe interpositus and prepositus hypoglossi in monkey. Vestibular and Brain Stem Control of Eye. Head and Body Movements, H. Y Shimazu Shinoda. Japan Science Society. Karger, Basel 1992; 125–135
   Google Scholar
• Zee D S., Robinson D A. A hypothetical explanation of saccadic oscillations. Ann Neurol 1979; 5: 405–414
   PubMed Web of Science ®Google Scholar
• Leigh J. Zee DS. The Neurology of Eye Movements, 2nd edition. F.A. Davis Company, Philadelphia 1991
   Google Scholar
• Hikosaka O, Igusa Y, Imai H. Inhibitory connections of nystagmus-related reticular burst neurons with neurons in the abducens, prepositus hypoglossi and vestibular nuclei in the cat. Exp Brain Res 1980; 39: 301–311
   PubMedGoogle Scholar
• Yoshida K, McCrea R, Berthoz A, Vidal P P. Morphological and physiological characteristics of inhibitory burst neurons controlling horizontal rapid eye movements in the alert cat. J Neurophysiol 1982; 48: 761–784
   PubMedGoogle Scholar
• Strassman A, Highstein S M, McCrea R A. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. II. Inhibitory burst neurons. J Comp Neurol 1986; 249: 358–380
   PubMedGoogle Scholar
• Goebel H H, Komatsuzaki A, Bender M B, Cohen B. Lesions of the pontine tegmentum and conjugate gaze paralysis. Arch Neurol (Chicago) 1971; 24: 431–440
   PubMedGoogle Scholar
• Cohen B, Komatsuzaki A. Eye movements induced by stimulation of the pontine reticular formation. Evidence for integration in oculomotor pathways. Exp Neurol 1972; 36: 101–117
   PubMedGoogle Scholar
• Büttner-Ennever J A, Büttner U. The reticular formation. Rev Oculomot Res 1988; 2: 119–176
   PubMedGoogle Scholar
• Langer T, Kaneko C RS, Scudder C A, Fuchs A F. Afferents to the abducens nucleus in the monkey and cat. J Comp Neurol 1986; 245: 379–400
   PubMedGoogle Scholar
• Strassman A, Highstein S M, McCrea R A. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. I. Excitatory burst neurons. J Comp Neurol 1986; 249: 337–357
   PubMedGoogle Scholar
• Horn A KE, Büttner-Ennever J A, Suzuki Henn Y. V. Histological identification of premotor neurons for horizontal saccades in monkey and man by parvalbumin immunostaining. J Comp Neurol 1995; 359: 350–363
   PubMed Web of Science ®Google Scholar
• Keller E L. Participation of medial pontine reticular formation in eye movement generation in monkey. J Neurophysiol 1974; 37: 316–332
   PubMed Web of Science ®Google Scholar
• Kaneko C RS, Evinger C, Fuchs A F. Role of pontine burst neurons in generation of saccadic eye movements. J Neurophysiol 1981; 46: 387–408
   PubMedGoogle Scholar
• Curthoys I S, Nakao S, Markham C H. Cat medial pontine reticular neurons related to vestibular nystagmus: firing pattern, location and projection. Brain Res 1981; 222: 75–94
   PubMed Web of Science ®Google Scholar
• Hepp K, Henn V. Spatio-temporal recoding of rapid eye movement signals in the monkey paramedian pontine reticular formation (PPRF). Exp Brain Res 1983; 52: 105–120
   PubMed Web of Science ®Google Scholar
• Crandall W F, Keller E L. Visual and oculomotor signals in nucleus reticularis tegmenti pontis in alert monkey. J Neurophysiol 1985; 54: 1326–1345
   PubMedGoogle Scholar
• Kaneko C RS, Fuchs A F. Inhibitory burst neurons in alert trained cats: comparison with excitatory burst neurons and functional implications. Progress in Oculomotor Research, A F Fuchs, W Becker. North Holland-Elsevier, New York 1981; 63–70
   Google Scholar
• Scudder C A, Fuchs A F, Langer T P. Characteristics and functional identification of saccadic inhibitory burst neurons in the alert monkey. J Neurophysiol 1988; 59: 1430–1454
   PubMed Web of Science ®Google Scholar
• Robinson F R, Phillips J O, Fuchs A F. Coordination of gaze shifts in primates: brainstem inputs to neck and extraocular motoneuron pools. J Comp Neurol 1994; 346: 43–62
   PubMedGoogle Scholar
• Olszewski J, Baxter D. Cytoarchitecture of the Human Brain Stem. Karger, Basel 1954
   Google Scholar
• Vilis T, Hepp K, Schwarz U, Henn V. On the generation of vertical and torsional rapid eye movements in the monkey. Exp Brain Res 1989; 77: 1–11
   PubMed Web of Science ®Google Scholar
• Büttner U, Büttner-Ennever J A, Henn V. Vertical eye movement related activity in the rostral mesencephalic reticular formation of the alert monkey. Brain Res 1977; 130: 239–252
   PubMed Web of Science ®Google Scholar
• Li W B, Shiraishi Y. Nakao S. Topographical organization of cat mesodiencephalic areas for monosynaptic activation of vertical oculomotoneurons. Exp Brain Res 1993; 94: 43–52
   PubMedGoogle Scholar
• Shiraishi Y, Nakao S. Differential locations in the midbrain of distinct groups of vertical eye movement-related neurones in cat: their projections and direct connections with oculomotor neurones. Acta Physiol Scand 1995; 154: 151–163
   PubMedGoogle Scholar
• Wang S F, Spencer R F. Spatial organization of premotor neurons related to vertical upward and downward saccadic eye movements in the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) in the cat. J Comp Neurol 1996; 366: 163–180
   PubMedGoogle Scholar
• Steiger H J, Büttner-Ennever J A. Oculomotor nucleus afferents in the monkey demonstrated with horseradish peroxidase. Brain Res 1979; 160: 1–15
   PubMedGoogle Scholar
• Moschovakis A K, Scudder C A, Highstein S M. Structure of the primate oculomotor burst generator. I. Medium-lead burst neurons with upward on-directions. J Neurophysiol 1991; 65: 203–217
   PubMedGoogle Scholar
• Moschovakis A K, Scudder C A, Highstein S M. Structure of the primate oculomotor burst generator. II. Medium-lead burst neurons with downward on-directions. J Neurophysiol 1991; 65: 218–229
   PubMedGoogle Scholar
• Büttner-Ennever J A, Büttner U, Cohen B, Baumgartner G. Vertical gaze paralysis and the rostral interstitial nucleus of the medial longitudinal fasciculus. Brain 1982; 105: 125–149
   PubMed Web of Science ®Google Scholar
• Büttner-Ennever J A, Cohen B, Pause M, Fries W. Raphe nucleus of the pons containing omnipause neurons of the oculomotor system in the monkey, and its homologue in man. J Comp Neurol 1988; 267: 307–321
   PubMed Web of Science ®Google Scholar
• Langer T P, Kaneko C RS. Brainstem afferents to the oculomotor omnipause neurons in monkey. J Comp Neurol 1990; 295: 413–427
   PubMedGoogle Scholar
• Horn A KE, Büttner-Ennever J A, Wahle P, Reichenberger I. Neurotransmitter profile of saccadic omnipause neurons in nucleus raphe interpositus. J Neurosci 1994; 14: 2032–2046
   PubMed Web of Science ®Google Scholar
• Baloh R W, Markham C H, Furuya N. Inhibition of pontine omnipauser neurons in the cat by 5-hydroxytryptophan. Exp Neurol 1982; 76: 586–593
   PubMed Web of Science ®Google Scholar
• Ashikawa H, Furuya N, Yabe T. Effects of serotonin, GABA and glycine on the activity of pause neurons during vestibular nystagmus in the cat. Acta Oto-Laryngol 1991; 111: 999–1005
   PubMed Web of Science ®Google Scholar
• Jacobs B L, Azmitia E C. Structure and function of the brain serotonin system. Physiol Rev 1992; 72: 165–229
   PubMed Web of Science ®Google Scholar
• Kamogawa H, Ohki Y, Shimazu H, Suzuki I, Yamashita M. Inhibitory input to pause neurons from pontine burst neuron area in the cat. Neurosci Lett 1996; 203: 163–166
   PubMedGoogle Scholar
• Büttner-Ennever J A, Horn A KE. Neuroanatomy of saccadic omnipause neurons in nucleus raphe interpositus. Contemporary Ocular Motor and Vestibular Research: A Tribute to David A. Robinson, A F Fuchs, T Brandt, U Biittner, D S Zee. Georg Thieme Verlag, Stuttgart, New York 1994; 488–495
   Google Scholar
• Pare M, Guitton D. The fixation area of the cat superior colliculus: effects of electrical stimulation and direct connection with brainstem omnipause neurons. Exp Brain Res 1994; 101: 109–122
   PubMedGoogle Scholar
• Spencer R F, Wenthold R J, Baker R. Evidence for glycine as an inhibitory neurotransmitter of vestibular, reticular, and prepositus hypoglossi neurons that project to the cat abdu-cens nucleus. J Neurosci 1989; 9: 2718–2736
   PubMed Web of Science ®Google Scholar
• Spencer R F, Wang S F. Immunohistochemical localization of neurotransmitters utilized by neurons in the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) that project to the oculomotor and trochlear nuclei in the cat. J Comp Neurol 1996; 366: 134–148
   PubMedGoogle Scholar
• Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 1984; 42: 1–11
   PubMed Web of Science ®Google Scholar
• Yingcharoen K, Rinvik E, Stormmathisen J, Ottersen O P. GABA, glycine, glutamate, aspartate and taurine in the perihypoglossal nuclei: an immunocytochemical investigation in the cat with particular reference to the issue of amino acid colocalization. Exp Brain Res 1989; 78: 345–357
   PubMedGoogle Scholar
• Ottersen O P. Quantitative electron microscopic immunocytocheniistry of neuroactive amino acids. Anat Embryol 1989; 180: 1–15
   PubMedGoogle Scholar
• Büttner-Ennever J A, Mehraein P, Wadia N. Neuropathology changes in oculomotor structures related to eye movement deficits in different varieties of OPCA. Int Congr Neuropathol Abstr 1986; 461: 229
   Google Scholar
• Koeppen A H. The nucleus pontis centralis caudalis in Huntington's disease. J Neurol Sci 1989; 91: 129–141
   PubMed Web of Science ®Google Scholar
• Ridley A, Kennard C, Scholtz C L, Büttner-Ennever J A, Summers B, Turnbull A. Omnipause neurons in two cases of opsoclonus associated with oat cell carcinoma of the lung. Brain 1987; 110: 1699–1709
   PubMed Web of Science ®Google Scholar
• Henn V, Lang W, Hepp K, Reisine H. Experimental gaze palsies in monkey and their relation to human pathology. Brain 1984; 107: 619–636
   PubMed Web of Science ®Google Scholar
• Hanson M R, Hamid H A, Tomsak R L, Chou S S, Leigh R J. Selective saccadic palsy caused by pontine lesions: clinical, physiological, and pathological correlations. Ann Neurol 1986; 20/2: 209–217
   Google Scholar
• Johnston J L, Sharpe J A, Ranalli R J, Morrow M J. Oblique misdirection and slowing of vertical saccades after unilateral lesions of the pontine tegmentum. Neurology 1993; 43: 2238–2244
   PubMedGoogle Scholar
• Kato I, Nakamura T, Kanayama R, Aoyagi M. Slow saccades and quick phases of nystagmus after pontine lesions. Acta Oto-Laryngol 1994; 11(Suppl 5)95–98
   Google Scholar
• Wadia N H, Swami R K. A new form of heredito-familial spinocerebellar degeneration with slow eye movements (nine families). Brain 1971; 94: 359–374
   PubMed Web of Science ®Google Scholar
• Plaitakis A, Berl S, Yahr M D. Neurological disorders associated with deficiency of glutamate dehydrogenase. Ann Neurol 1984; 15: 144–153
   PubMed Web of Science ®Google Scholar
• Leigh R J, Averbuch-Heller L, Tomsak R L, Remler B F, Yaniglos S S, Del'Osso L F. Treatment of abnormal eye movements that impair vision: strategies based on current concepts of physiology and pharmacology. Ann Neurol 1994; 36: 129–141
   PubMedGoogle Scholar