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Orbit
The International Journal on Orbital Disorders, Oculoplastic and Lacrimal Surgery
Volume 29, 2010 - Issue 5
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Original Article

The Role of Intravenous Methylprednisolone Immunosuppression in the Management of Active Thyroid Eye Disease

Katya TambeLid, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UKCorrespondence[email protected]
,
Jonathan BhargavaLid, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
,
Ajay TripathiLid, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
,
Marelena GregoryLid, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
,
Joyce BurnsLid, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
&
Raghavan SampathLid, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
Pages 227-231 | Received 27 Oct 2009, Accepted 20 Dec 2009, Published online: 02 Sep 2010

REFERENCES

  • Burch HB, Wartofsky L. Graves’ ophthalmopathy: current concepts regarding pathogenesis and management. Endocr Rev 1993;14:747–793.
  • Gorman CA. Clinical features of Graves’ ophthalmopathy in an incidence cohort. Am J Ophthalmol 1996;121:284–290.
  • Bartalena L, Pinchera A, Marcocci C. Management of Graves’ ophthalmopathy: reality and perspectives. Endocr Rev 2000;21:168–199.
  • Bahn RS, Heufelder AE. Pathogenesis of Graves’ ophthalmopathy. N Engl J Med 1993;329:1468–1475.
  • Perros P, Kendall-Taylor P. Pathogenesis of thyroid-associated ophthalmopathy. Trends Endocrinol Metab 1993;4:270–275.
  • Heufelder AE. Pathogenesis of Graves’ ophthalmopathy: recent controversies and progress. Eur J Endocrinol 1995;132:532–541.
  • Hales IB, Thomas ID. Treatment of thyroid ophthalmopathy with corticoid analogues. Australas Ann Med 1962;11:113–117.
  • Guy JR, Fagien S, Donovan JP, Rubin ML. Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy. Ophthalmology 1989;96:1048–1053.
  • Boulos PR, Hardy I. Thyroid-associated orbitopathy: a clinicopathologic and therapeutic review. Curr Opin Ophthalmol 2004;15:389–400.
  • Kahaly GJ, Pitz S, Hommel G, Dittmar M. Randomized, single blind trial of intravenous versus oral steroid monotherapy in Graves’ orbitopathy. J Clin Endocrinol Metab 2005;90:5234–5240.
  • Zoumalan CI, Cockerham KP, Turbin RE et al. Efficacy of corticosteroids and external beam radiation in the management of moderate to severe thyroid eye disease. J Neuroophthalmol 2007;27:205–214.
  • Mourits MP, Prummel MF, Wiersinga WM, Koornneef L. Clinical activity score as a guide in the management of patients with Graves’ ophthalmopathy. Clin Endocrinol (Oxf) 1997;47:9–14.
  • Wiersinga WM. Immunosuppressive treatment of Graves’ ophthalmopathy. Trends Endocrinol Metab 1990;1:377–381.
  • Bartalena L, Marcocci C, Pinchera A. Treating severe Graves’ ophthalmopathy. Baillieres Clin Endocrinol Metab 1997;11:521–536.
  • Marcocci C, Bartalena L, Marinò M et al. Current medical management of Graves ophthalmopathy. Ophthal Plast Reconstr Surg 2002;18:402–408.
  • Marcocci C, Bartalena L, Tanda ML et al. Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves’ ophthalmopathy: results of a prospective, single-blind, randomized study. J Clin Endocrinol Metab 2001;86:3562–3567.
  • Le Moli R, Baldeschi L, Saeed P et al. Determinants of liver damage associated with intravenous methylprednisolone pulse therapy in Graves’ ophthalmopathy. Thyroid 2007;17:357–362.
  • Bahn RS, Gorman CA. Choice of therapy and criteria for assessing treatment outcome in thyroid-associated ophthalmopathy. Endocrinol Metab Clin North Am 1987;16:391–407.
  • Mourits MP, van Kempen-Harteveld ML, García MB et al. Radiotherapy for Graves’ orbitopathy: randomised placebo-controlled study. Lancet 2000;355:1505–1509.
  • Gorman CA, Garrity JA, Fatourechi V et al. A prospective, randomized, double-blind, placebo-controlled study of orbital radiotherapy for Graves’ ophthalmopathy. Ophthalmology 2001;108:1523–1534.
  • Ohtsuka K, Sato A, Kawaguchi S, Hashimoto M, Suzuki Y. Effect of steroid pulse therapy with and without orbital radiotherapy on Graves’ ophthalmopathy. Am J Ophthalmol 2003;135:285–290.
  • Meyer PA. Avoiding surgery for thyroid eye disease. Eye (Lond) 2006;20:1171–1177.
  • Claridge KG, Ghabrial R, Davis G et al. Combined radiotherapy and medical immunosuppression in the management of thyroid eye disease. Eye (Lond) 1997;11 (Pt 5):717–722.
  • Paridaens D, van den Bosch WA, van der Loos TL, Krenning EP, van Hagen PM. The effect of etanercept on Graves’ ophthalmopathy: a pilot study. Eye (Lond) 2005;19:1286–1289.
  • Durrani OM, Reuser TQ, Murray PI. Infliximab: a novel treatment for sight-threatening thyroid associated ophthalmopathy. Orbit 2005;24:117–119.
  • Krassas GE, Dumas A, Pontikides N, Kaltsas T. Somatostatin receptor scintigraphy and octreotide treatment in patients with thyroid eye disease. Clin Endocrinol (Oxf) 1995;42:571–580.
  • Krassas GE, Boboridis K. Recent developments in the medical treatment of thyroid eye disease. Orbit 2006;25:117–122.

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