Neurogenetics of Slow Axonal Transport: From Cells to Animals

REFERENCES

• Alami, N. H., Jung, P., & Brown, A. (2009).Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses.J Neurosci, 29, 6625–6634.
   PubMed Web of Science ®Google Scholar
• Allen, R. D., Weiss, D. G., Hayden, J. H., Brown, D. T., Fujiwake, H., & Simpson, M. (1985).Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: Evidence for an active role of microtubules in cytoplasmic transport.J Cell Biol, 100, 1736–1752.
   PubMed Web of Science ®Google Scholar
• Alonso, A. C., Zaidi, T., Grundke-Iqbal, I., & Iqbal, K. (1994).Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.Proc Natl Acad Sci USA, 91, 5562–5566.
   PubMed Web of Science ®Google Scholar
• Arimura, N., & Kaibuchi, K. (2007).Neuronal polarity: From extracellular signals to intracellular mechanisms.Nat Rev Neurosci, 8, 194–205.
   PubMed Web of Science ®Google Scholar
• Baas, P. W., & Buster, D. W. (2004).Slow axonal transport and the genesis of neuronal morphology.J Neurobiol, 58, 3–17.
   Google Scholar
• Baqri, R., Charan, R., Schimmelpfeng, K., Chavan, S., & Ray, K. (2006).Kinesin-2 differentially regulates the anterograde axonal transports of acetylcholinesterase and choline acetyltransferase in Drosophila.J Neurobiol, 66, 378–392.
   PubMedGoogle Scholar
• Bilsland, L. G., Sahai, E., Kelly, G., Golding, M., Greensmith, L., & Schiavo, G. (2010).Deficits in axonal transport precede ALS symptoms in vivo.Proc Natl Acad Sci USA, 107, 20523–20528.
   PubMed Web of Science ®Google Scholar
• Black, M. M., Chestnut, M. H., Pleasure, I. T., & Keen, J. H. (1991).Stable clathrin: Uncoating protein (hsc70) complexes in intact neurons and their axonal transport.J Neurosci, 11, 1163–1172.
   PubMed Web of Science ®Google Scholar
• Black, M. M., & Lasek, R. J. (1979).Axonal transport of actin: Slow component b is the principal source of actin for the axon.Brain Res, 171, 401–413.
   PubMed Web of Science ®Google Scholar
• Black, M. M., & Lasek, R. J. (1980).Slow components of axonal transport: Two cytoskeletal networks.J Cell Biol, 86, 616–623.
   PubMed Web of Science ®Google Scholar
• Borchelt, D. R., Wong, P. C., Becher, M. W., Pardo, C. A., Lee, M. K., Xu, Z. S., . (1998).Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.Neurobiol Dis, 5, 27–35.
   PubMed Web of Science ®Google Scholar
• Brady, S. T., & Lasek, R. J. (1981).Nerve-specific enolase and creatine phosphokinase in axonal transport: Soluble proteins and the axoplasmic matrix.Cell, 23, 515–523.
   PubMed Web of Science ®Google Scholar
• Brown, A. (2003).Axonal transport of membranous and nonmembranous cargoes: A unified perspective.J Cell Biol, 160, 817–821.
   PubMed Web of Science ®Google Scholar
• Brown, A. (Ed.). (2009).New encyclopedia of neuroscience, Vol. 9. Oxford, UK: Academic Press.
   Google Scholar
• Chang, S., Rodionov, V. I., Borisy, G. G., & Popov, S. V. (1998).Transport and turnover of microtubules in frog neurons depend on the pattern of axonal growth.J Neurosci, 18, 821–829.
   PubMed Web of Science ®Google Scholar
• Conde, C., & Caceres, A. (2009).Microtubule assembly, organization and dynamics in axons and dendrites.Nat Rev Neurosci, 10, 319–332.
   PubMed Web of Science ®Google Scholar
• De Vos, K. J., Grierson, A. J., Ackerley, S., & Miller, C. C. (2008).Role of axonal transport in neurodegenerative diseases.Annu Rev Neurosci, 31, 151–173.
   PubMed Web of Science ®Google Scholar
• Dillman, J. F., 3rd, Dabney, L. P., Karki, S., Paschal, B. M., Holzbaur, E. L., & Pfister, K. K. (1996).Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport.J Neurosci, 16, 6742–6752.
   PubMed Web of Science ®Google Scholar
• Doodhi, H., Ghosal, D., Krishnamurthy, M., Jana, S. C., Shamala, D., Bhaduri, A., . (2009).KAP, the accessory subunit of kinesin-2, binds the predicted coiled-coil stalk of the motor subunits.Biochemistry, 48, 2248–2260.
   PubMed Web of Science ®Google Scholar
• Duncan, J. E., & Goldstein, L. S. (2006).The genetics of axonal transport and axonal transport disorders.PLoS Genet, 2, e124.
   Web of Science ®Google Scholar
• Falzone, T. L., Stokin, G. B., Lillo, C., Rodrigues, E. M., Westerman, E. L., Williams, D. S., . (2009).Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.J Neurosci, 29, 5758–5767.
   PubMed Web of Science ®Google Scholar
• Garner, J. A., & Lasek, R. J. (1981).Clathrin is axonally transported as part of slow component b: The microfilament complex.J Cell Biol, 88, 172–178.
   PubMed Web of Science ®Google Scholar
• Garner, J. A., & Lasek, R. J. (1982).Cohesive axonal transport of the slow component b complex of polypeptides.J Neurosci, 2, 1824–1835.
   PubMed Web of Science ®Google Scholar
• Garrido, J. J., Giraud, P., Carlier, E., Fernandes, F., Moussif, A., Fache, M. P., . (2003).A targeting motif involved in sodium channel clustering at the axonal initial segment.Science, 300, 2091–2094.
   PubMed Web of Science ®Google Scholar
• Gower, D. J., & Tytell, M. (1987).Axonal transport of clathrin-associated proteins.Brain Res, 407, 1–8.
   PubMed Web of Science ®Google Scholar
• Grafstein, B., & Forman, D. S. (1980).Intracellular transport in neurons.Physiol Rev, 60, 1167–1283.
   PubMed Web of Science ®Google Scholar
• Gros-Louis, F., Kriz, J., Kabashi, E., McDearmid, J., Millecamps, S., Urushitani, M., . (2008).Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish.Hum Mol Genet, 17, 2691–2702.
   Google Scholar
• Gross, G. W. (1975).The microstream concept of axoplasmic and dendritic transport.Adv Neurol, 12, 283–296.
   PubMedGoogle Scholar
• Gunawardena, S., & Goldstein, L. S. (2001).Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.Neuron, 32, 389–401.
   PubMedGoogle Scholar
• Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., . (1994).Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation.Science, 264, 1772–1775.
   PubMed Web of Science ®Google Scholar
• Hadano, S., Hand, C. K., Osuga, H., Yanagisawa, Y., Otomo, A., Devon, R. S., . (2001).A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.Nat Genet, 29, 166–173.
   PubMed Web of Science ®Google Scholar
• He, Y., Francis, F., Myers, K. A., Yu, W., Black, M. M., & Baas, P. W. (2005).Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.J Cell Biol, 168, 697–703.
   PubMed Web of Science ®Google Scholar
• Hernandez, F., & Avila, J. (2007).Tauopathies.Cell Mol Life Sci, 64, 2219–2233.
   PubMed Web of Science ®Google Scholar
• Hirokawa, N., Sobue, K., Kanda, K., Harada, A., & Yorifuji, H. (1989).The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1.J Cell Biol, 108, 111–126.
   PubMed Web of Science ®Google Scholar
• Hoffman, P. N., & Lasek, R. J. (1975).The slow component of axonal transport.Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J Cell Biol, 66, 351–366.
   Google Scholar
• Hollenbeck, P. J., & Saxton, W. M. (2005).The axonal transport of mitochondria.J Cell Sci, 118(Pt 23), 5411–5419.
   PubMed Web of Science ®Google Scholar
• Kaether, C., Skehel, P., & Dotti, C. G. (2000).Axonal membrane proteins are transported in distinct carriers: A two-color video microscopy study in cultured hippocampal neurons.Mol Biol Cell, 11, 1213–1224.
   PubMed Web of Science ®Google Scholar
• Katsuki, T., Ailani, D., Hiramoto, M., & Hiromi, Y. (2009).Intra-axonal patterning: Intrinsic compartmentalization of the axonal membrane in Drosophila neurons.Neuron, 64, 188–199.
   PubMed Web of Science ®Google Scholar
• Konzack, S., Thies, E., Marx, A., Mandelkow, E. M., & Mandelkow, E. (2007).Swimming against the tide: Mobility of the microtubule-associated protein tau in neurons.J Neurosci, 27, 9916–9927.
   PubMed Web of Science ®Google Scholar
• Lasek, R. J., Garner, J. A., & Brady, S. T. (1984).Axonal transport of the cytoplasmic matrix.J Cell Biol, 99(1 Pt 2), 212s–221s.
   Web of Science ®Google Scholar
• Lindwall, G., & Cole, R. D. (1984).Phosphorylation affects the ability of tau protein to promote microtubule assembly.J Biol Chem, 259, 5301–5305.
   PubMed Web of Science ®Google Scholar
• McEwen, B. S., & Grafstein, B. (1968).Fast and slow components in axonal transport of protein.J Cell Biol, 38, 494–508.
   PubMed Web of Science ®Google Scholar
• Miller, K. E., & Heidemann, S. R. (2008).What is slow axonal transport?Exp Cell Res, 314, 1981–1990.
   PubMed Web of Science ®Google Scholar
• Morfini, G. A., Burns, M., Binder, L. I., Kanaan, N. M., LaPointe, N., Bosco, D. A., . (2009).Axonal transport defects in neurodegenerative diseases.J Neurosci, 29, 12776–12786.
   PubMed Web of Science ®Google Scholar
• Ochs, S. (1975).A unitary concept of axoplasmic transport based on the transport filament hypothesis. In: G.-M. Bradley, Walton (Eds.), Recent Advances in Myology. Amsterdam: Excerpta Med, 1975, pp. 189–194.
   Google Scholar
• Oda, Y. (1999).Choline acetyltransferase: The structure, distribution and pathologic changes in the central nervous system.Pathol Int, 49, 921–937.
   PubMed Web of Science ®Google Scholar
• Pasinelli, P., & Brown, R. H. (2006).Molecular biology of amyotrophic lateral sclerosis: Insights from genetics.Nat Rev Neurosci, 7, 710–723.
   PubMed Web of Science ®Google Scholar
• Rao, M. V., Engle, L. J., Mohan, P. S., Yuan, A., Qiu, D., Cataldo, A., . (2002).Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.J Cell Biol, 159, 279–290.
   PubMed Web of Science ®Google Scholar
• Ray, K., Perez, S. E., Yang, Z., Xu, J., Ritchings, B. W., Steller, H., . (1999).Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila.J Cell Biol, 147, 507–518.
   PubMed Web of Science ®Google Scholar
• Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., . (1993).Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.Nature, 362, 59–62.
   PubMed Web of Science ®Google Scholar
• Roy, S., Coffee, P., Smith, G., Liem, R. K., Brady, S. T., & Black, M. M. (2000).Neurofilaments are transported rapidly but intermittently in axons: Implications for slow axonal transport.J Neurosci, 20, 6849–6861.
   PubMed Web of Science ®Google Scholar
• Roy, S., Winton, M. J., Black, M. M., Trojanowski, J. Q., & Lee, V. M. (2007).Rapid and intermittent cotransport of slow component-b proteins.J Neurosci, 27, 3131–3138.
   PubMed Web of Science ®Google Scholar
• Roy, S., Winton, M. J., Black, M. M., Trojanowski, J. Q., & Lee, V. M. (2008).Cytoskeletal requirements in axonal transport of slow component-b.J Neurosci, 28, 5248–5256.
   PubMed Web of Science ®Google Scholar
• Roy, S., Zhang, B., Lee, V. M., & Trojanowski, J. Q. (2005).Axonal transport defects: A common theme in neurodegenerative diseases.Acta Neuropathol, 109, 5–13.
   PubMed Web of Science ®Google Scholar
• Sadananda, A., Hamid, R., Doodhi, H., Ghosal, D., Girotra, M., Jana, S. C., . (2012).Interaction with a kinesin-2 tail propels choline acetyltransferase flow toward synapse. Traffic. 13: 979–991.
   Google Scholar
• Saha, A. R., Hill, J., Utton, M. A., Asuni, A. A., Ackerley, S., Grierson, A. J., . (2004).Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.J Cell Sci, 117(Pt 7), 1017–1024.
   PubMed Web of Science ®Google Scholar
• Scott, D. A., Das, U., Tang, Y., & Roy, S. (2011).Mechanistic logic underlying the axonal transport of cytosolic proteins.Neuron, 70, 441–454.
   PubMed Web of Science ®Google Scholar
• Seitz, A., Kojima, H., Oiwa, K., Mandelkow, E. M., Song, Y. H., & Mandelkow, E. (2002).Single-molecule investigation of the interference between kinesin, tau and MAP2c.EMBO J, 21, 4896–4905.
   PubMed Web of Science ®Google Scholar
• Shah, J. V., & Cleveland, D. W. (2002).Slow axonal transport: Fast motors in the slow lane.Curr Opin Cell Biol, 14, 58–62.
   PubMed Web of Science ®Google Scholar
• Stromska, D. P., & Ochs, S. (1981).Patterns of slow transport in sensory nerves.J Neurobiol, 12, 441–453.
   PubMedGoogle Scholar
• Tashiro, T., Sun, X., Tsuda, M., & Komiya, Y. (1996).Differential axonal transport of soluble and insoluble tau in the rat sciatic nerve.J Neurochem, 67, 1566–1574.
   PubMed Web of Science ®Google Scholar
• Tateno, M., Kato, S., Sakurai, T., Nukina, N., Takahashi, R., & Araki, T. (2009).Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.Hum Mol Genet, 18, 942–955.
   PubMed Web of Science ®Google Scholar
• Terada, S., Kinjo, M., & Hirokawa, N. (2000).Oligomeric tubulin in large transporting complex is transported via kinesin in squid giant axons.Cell, 103, 141–155.
   PubMed Web of Science ®Google Scholar
• Trivedi, N., Jung, P., & Brown, A. (2007).Neurofilaments switch between distinct mobile and stationary states during their transport along axons.J Neurosci, 27, 507–516.
   PubMed Web of Science ®Google Scholar
• Tytell, M., Black, M. M., Garner, J. A., & Lasek, R. J. (1981).Axonal transport: Each major rate component reflects the movement of distinct macromolecular complexes.Science, 214, 179–181.
   PubMed Web of Science ®Google Scholar
• Uchida, A., Alami, N. H., & Brown, A. (2009).Tight functional coupling of kinesin-1A and dynein motors in the bi-directional transport of neurofilaments.Mol Biol Cell, 20(23), 4997–5006.
   PubMed Web of Science ®Google Scholar
• Vale, R. D., Schnapp, B. J., Reese, T. S., & Sheetz, M. P. (1985).Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon.Cell, 40, 559–569.
   PubMed Web of Science ®Google Scholar
• Wang, L., & Brown, A. (2001).Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.Mol Biol Cell, 12, 3257–3267.
   PubMed Web of Science ®Google Scholar
• Wang, L., & Brown, A. (2002).Rapid movement of microtubules in axons.Curr Biol, 12, 1496–1501.
   PubMed Web of Science ®Google Scholar
• Wang, L., & Brown, A. (2010).A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport.Mol Neurodegener, 5, 52.doi:10.1186/1750-1326-5-52
   PubMed Web of Science ®Google Scholar
• Wang, L., Ho, C. L., Sun, D., Liem, R. K., & Brown, A. (2000).Rapid movement of axonal neurofilaments interrupted by prolonged pauses.Nat Cell Biol, 2, 137–141.
   PubMed Web of Science ®Google Scholar
• Willard, M., Cowan, W. M., & Vagelos, P. R. (1974).The polypeptide composition of intra-axonally transported proteins: Evidence for four transport velocities.Proc Natl Acad Sci USA, 71, 2183–2187.
   PubMed Web of Science ®Google Scholar
• Williamson, T. L., & Cleveland, D. W. (1999).Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons.Nat Neurosci, 2, 50–56.
   PubMed Web of Science ®Google Scholar
• Winckler, B., Forscher, P., & Mellman, I. (1999).A diffusion barrier maintains distribution of membrane proteins in polarized neurons.Nature, 397, 698–701.
   PubMed Web of Science ®Google Scholar
• Wollner, D. A., & Catterall, W. A. (1986).Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells.Proc Natl Acad Sci USA, 83, 8424–8428.
   PubMed Web of Science ®Google Scholar
• Wooten, G. F., & Cheng, C. H. (1980).Transport and turnover of acetylcholinesterase and choline acetyltransferase in rat sciatic nerve and skeletal muscle.J Neurochem, 34, 359–366.
   PubMed Web of Science ®Google Scholar
• Xia, C. H., Roberts, E. A., Her, L. S., Liu, X., Williams, D. S., Cleveland, D. W., . (2003).Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.J Cell Biol, 161, 55–66.
   PubMed Web of Science ®Google Scholar
• Yabe, J. T., Chan, W. K., Chylinski, T. M., Lee, S., Pimenta, A. F., & Shea, T. B. (2001).The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation, and maturation.Cell Motil Cytoskeleton, 48, 61–83.
   PubMed Web of Science ®Google Scholar
• Yang, Y., Hentati, A., Deng, H. X., Dabbagh, O., Sasaki, T., Hirano, M., . (2001).The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.Nat Genet, 29, 160–165.
   PubMed Web of Science ®Google Scholar
• Yuan, A., Mills, R. G., Bamburg, J. R., & Bray, J. J. (1999).Cotransport of glyceraldehyde-3-phosphate dehydrogenase and actin in axons of chicken motoneurons.Cell Mol Neurobiol, 19, 733–744.
   PubMed Web of Science ®Google Scholar
• Zhang, B., Tu, P., Abtahian, F., Trojanowski, J. Q., & Lee, V. M. (1997).Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation.J Cell Biol, 139, 1307–1315.
   PubMed Web of Science ®Google Scholar
• Zhou, D., Lambert, S., Malen, P. L., Carpenter, S., Boland, L. M., & Bennett, V. (1998).AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing.J Cell Biol, 143, 1295–1304.
   PubMed Web of Science ®Google Scholar