Inhibition of secretory phospholipase A₂ activity attenuates lipopolysaccharide-induced acute lung injury in a mouse model

REFERENCES

• Piantadosi CA, Schwartz DA: The acute respiratory distress syndrome. Ann Intern Med. 2004;141:460–470.
   PubMed Web of Science ®Google Scholar
• Wheeler AP, Bernard GR: Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet. 2007;369:1553–1564.
   PubMed Web of Science ®Google Scholar
• Ware LB, Matthay MA: The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334–1349.
   PubMed Web of Science ®Google Scholar
• Nakos G, Kitsiouli E, Hatzidaki E, Koulouras V, Touqui L, Lekka ME: Phospholipases A2 and platelet-activating-factor acetylhydrolase in patients with acute respiratory distress syndrome. Crit Care Med. 2005;33:772–779.
   PubMed Web of Science ®Google Scholar
• Kim DK, Fukuda T, Thompson BT, Cockrill B, Hales C, Bonventre JV: Bronchoalveolar lavage fluid phospholipase A2 activities are increased in human adult respiratory distress syndrome. Am J Physiol. 1995;269:L109–L118.
   PubMed Web of Science ®Google Scholar
• Edelson JD, Vadas P, Villar J, Mullen JB, Pruzanski W: Acute lung injury induced by phospholipase A2. Structural and functional changes. Am Rev Respir Dis. 1991;143:1102– 1109.
   PubMed Web of Science ®Google Scholar
• Seeds MC, Jones KA, Duncan Hite R, Willingham MC, Borgerink HM, Woodruff RD, Bowton DL, Bass DA: Cell-specific expression of group X and group V secretory phospholipases A (2) in human lung airway epithelial cells. Am J Respir Cell Mol Biol. 2000;23:37–44.
   PubMed Web of Science ®Google Scholar
• Masuda S, Murakami M, Mitsuishi M, Komiyama K, Ishikawa Y, Ishii T, Kudo I: Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells. Biochem J. 2005;387:27–38.
   PubMed Web of Science ®Google Scholar
• Nagase T, Uozumi N, Ishii S, Kita Y, Yamamoto H, Ohga E, Ouchi Y, Shimizu T: A pivotal role of cytosolic phospholipase A (2) in bleomycin-induced pulmonary fibrosis. Nat Med. 2002;8:480–484.
   PubMed Web of Science ®Google Scholar
• Nagase T, Uozumi N, Ishii S, Kume K, Izumi T, Ouchi Y, Shimizu T: Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nat Immunol. 2000;1:42–46.
   PubMed Web of Science ®Google Scholar
• Balsinde J, Winstead MV, Dennis EA: Phospholipase A2 regulation of arachidonic acid mobilization. FEBS Lett. 2002;531:2–6.
   PubMed Web of Science ®Google Scholar
• Murakami M, Kudo I: Secretory phospholipase A2. Biol Pharm Bull. 2004;27:1158–1164.
   PubMed Web of Science ®Google Scholar
• Diaz BL, Arm JP: Phospholipase A2. Prostaglandins Leukot Essent Fatty Acids. 2003;69:87–97.
   PubMed Web of Science ®Google Scholar
• Pruzanski W, Vadas P: Phospholipase A2—a mediator between proximal and distal effectors of inflammation. Immunol Today. 1991;12:143–146.
   PubMedGoogle Scholar
• Tischfield JA: A reassessment of the low molecular weight phospholipase A2 gene family in mammals. J Biol Chem. 1997;272:17247–17250.
   PubMed Web of Science ®Google Scholar
• Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G: On the diversity of secreted phospholipases A2. Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. J Biol Chem. 1999;274:31195–31202.
   PubMed Web of Science ®Google Scholar
• Murakami M, Nakatani Y, Kuwata H, Kudo I: Cellular components that functionally interact with signaling phospholipase A2s. Biochim Biophys Acta. 2000;1488:159–166.
   PubMed Web of Science ®Google Scholar
• Furue S, Mikawa K, Nishina K, Shiga M, Ueno M, Tomita Y, Kuwabara K, Teshirogi I, Ono T, Hori Y, Matsukawa A, Yoshinaga M, Obara H: Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection. Crit Care Med. 2001;29:719–727.
   PubMed Web of Science ®Google Scholar
• Kennedy BP, Payette P, Mudgett J, Vadas P, Pruzanski W, Kwan M, Tang C, Rancourt DE, Cromlish WA: A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains. J Biol Chem. 1995;270:22378–22385.
   PubMed Web of Science ®Google Scholar
• Fujioka D, Saito Y, Kobayashi T, Yano T, Tezuka H, Ishimoto Y, Suzuki N, Yokota Y, Nakamura T, Obata JE, Kanazawa M, Kawabata K, Hanasaki K, Kugiyama K: Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice. Circulation. 2008;117:2977–2985.
   PubMed Web of Science ®Google Scholar
• Kristof AS, Goldberg P, Laubach V, Hussain SN: Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury. Am J Respir Crit Care Med. 1998;158:1883–1889.
   PubMed Web of Science ®Google Scholar
• Henderson WR Jr, Chi EY, Bollinger JG, Tien YT, Ye X, Castelli L, Rubtsov YP, Singer AG, Chiang GK, Nevalainen T, Rudensky AY, Gelb MH: Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med. 2007;204:865–877.
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Chi EY, Singer AG, Gelb MH, Henderson WR Jr: Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2007;176:1072–1078.
   PubMed Web of Science ®Google Scholar
• Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB: Synergism between leukotriene B4 and thromboxane A2 in mediating acid-aspiration injury. Surgery. 1992;111:55–61.
   PubMed Web of Science ®Google Scholar
• Curfs DM, Ghesquiere SA, Vergouwe MN, Van Der Made I, Gijbels MJ, Greaves DR, Verbeek JS, Hofker MH, de Winther MP: Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. J Biol Chem. 2008;283:21640–21648.
   PubMed Web of Science ®Google Scholar
• Ohtsuki M, Taketomi Y, Arata S, Masuda S, Ishikawa Y, Ishii T, Takanezawa Y, Aoki J, Arai H, Yamamoto K, Kudo I, Murakami M: Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction. J Biol Chem. 2006;281:36420–36433.
   PubMed Web of Science ®Google Scholar
• Arbibe L, Koumanov K, Vial D, Rougeot C, Faure G, Havet N, Longacre S, Vargaftig BB, Bereziat G, Voelker DR, Wolf C, Touqui L: Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction. J Clin Invest. 1998;102:1152–1160.
   PubMed Web of Science ®Google Scholar
• Balestrieri B, Maekawa A, Xing W, Gelb MH, Katz HR, Arm JP: Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. J Immunol. 2009;182:4891–4898.
   PubMed Web of Science ®Google Scholar
• Zeiher BG, Steingrub J, Laterre PF, Dmitrienko A, Fukiishi Y, Abraham E; EZZI Study Group: LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis. Crit Care Med. 2005;33:1741–1748.
   PubMed Web of Science ®Google Scholar
• Sato H, Taketomi Y, Isogai Y, Masuda S, Kobayashi T, Yamamoto K, Murakami M: Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation. Biochem J. 2009;421:17–27.
   PubMed Web of Science ®Google Scholar
• Munoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR: Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice. Am J Physiol Lung Cell Mol Physiol. 2009;296:L879–L887.
   PubMed Web of Science ®Google Scholar