Neurogenic inflammation in allergen-challenged obese mice: a missing link in the obesity-asthma association?

REFERENCES

• Beuther DA, Sutherland ER: Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175(7):661–666.
   PubMed Web of Science ®Google Scholar
• Farah C, Salome C: Asthma and obesity –a known association but unknown mechanism. Respirology. 2011; 14:412–421.
   Google Scholar
• Lessard A, Turcotte H, Cormier Y, Boulet LP: Obesity and asthma: a specific phenotype? Chest. 2008;134(2):317–323.
   PubMed Web of Science ®Google Scholar
• Lugogo NL, Kraft M, Dixon AE: Does obesity produce a distinct asthma phenotype? J Appl Physiol. 2010 Mar;108(3): 729–734.
   PubMed Web of Science ®Google Scholar
• Beuther DA: Recent insight into obesity and asthma. Curr Opin Pulm Med. 2010 Jan;16(1):64–70.
   PubMed Web of Science ®Google Scholar
• Shore SA: Obesity and asthma: possible mechanisms. J Allerg Clinic Immun. 2008;121(5):1087–1093.
   PubMed Web of Science ®Google Scholar
• Scott HA, Dibson PG, Garg ML, LG W: Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Resp J. 2011;38(3):594–602.
   PubMed Web of Science ®Google Scholar
• Farah CS, Kermode JA, Downie SR, Brown NJ, Hardaker KM, Berend N, et al.: Obesity is a determinant of asthma control, independent of inflammation and lung mechanics. Chest. 2011;140:659–666.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Berger A, Milne CD, Paige CJ: Tachykinins in the immune system. Curr Drug Targets. 2006;7(8):1011–1020.
   PubMed Web of Science ®Google Scholar
• Groneberg D, Quarcoo D, Frossard N, Fisher A: Neurogenic mechanisms in bronchial inflammatory diseases. Allergy. 2004;59:1139–1152.
   PubMed Web of Science ®Google Scholar
• Karagiannides I, Pothoulakis C: Substance P, obesity, and gut inflammation. Current Opinion in Endocrinology, Diabetes and Obesity. 2009;16(1):47–52.
   Google Scholar
• De Swert KO, Joos GF: Extending the understanding of sensory neuropeptides. Eur J Pharmacol. 2006 Mar 8;533(1–3): 171–181.
   PubMed Web of Science ®Google Scholar
• Cima K, Vogelsinger H, Kahler CM: Sensory neuropeptides are potent chemoattractants for human basophils in vitro. Regul Pept. 2010 Feb 25;160(1–3):42–48.
   PubMed Web of Science ®Google Scholar
• Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C: Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1012–G1019.
   PubMed Web of Science ®Google Scholar
• Karagiannides I, Torres D, Tseng Y, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E: Substance P as a novel anti-obesity target. Gastroenterology. 2008;134(3):747–755.e1.
   PubMed Web of Science ®Google Scholar
• Karagiannides I, Bakirtzi K, Kokkotou E, Stavrakis D, Gross Margolis K, Thomou T, Giorgadze N, Kirkland JL, Pothoulakis C: Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology. 2011.
   Google Scholar
• Fu J, Liu B, Liu P, Liu L, Li G, Wu B, Liu X.: Substance P is associated with the development of obesity, chronic inflammation and type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2011;119(3):177–181.
   PubMed Web of Science ®Google Scholar
• Patterson R, Johnston B, Ardill J, Heaney L, McGarvey L: Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux. Thorax. 2007;62(468–469).
   PubMedGoogle Scholar
• Chu HW, Kraft M, Krause JE, Rex MD, Martin RJ: Substance P and its receptor neurokinin 1 expression in asthmatic airways. J Allergy Clin Immunol. 2000 Oct;106(4):713–22.
   PubMed Web of Science ®Google Scholar
• Hens G, Raap U, Vanoirbeek J, Meyts I, Callebaut I, Verbinnen B, Vanaudenaerde BM, Cadot P, Nemery B, Bullens DMA, Ceuppens JL, Hellings PW: Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness. Am J Respir Cell Mol Biol. 2011 Apr;44(4):517–523.
   PubMed Web of Science ®Google Scholar
• Barnes PJ: Neurogenic inflammation in the airways. Respir Physiol. 2001 Mar;125(1–2):145–154.
   PubMedGoogle Scholar
• Yamashita N: Animal models of asthma. Respiration and Circulation. 2008;56(9):887–892.
   Google Scholar
• Dinh QT, Mingomataj E, Quarcoo D, Groneberg DA, Witt C, Klapp BF, : Allergic airway inflammation induces tachykinin peptides expression in vagal sensory neurons innervating mouse airways. Clinical and Experimental Allergy. 2005;35(6):820–825.
   PubMed Web of Science ®Google Scholar
• Silveira PS, Palmares MC, Delgado L: [Bronchoalveolar lavage: methodology and clinical application] (translated from Portuguese). Rev Port Pneumonol 1997;III(2):155–178.
   Google Scholar
• Cataldo DD, Tournoy KG, Vermaelen K, Munaut C, Foidart JM, Louis R, Noel A, Pauwels RA: Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation. Am J Pathol. 2002 Aug;161(2):491–498.
   PubMed Web of Science ®Google Scholar
• Soares R, Costa C: Oxidative stress, inflammation and angiogenesis in the metabolic syndrome. Soares R, Costa C, editors: Springer; 2009.
   Google Scholar
• Cohn L, Elias JA, Chupp GL: Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol. 2004;22: 789–815.
   PubMed Web of Science ®Google Scholar
• Williams R, Zou X, Hoyle GW: Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kB via a Gq-dependent pathway. Am J Physiol–Lung C. 2007;292(2):L430–L437.
   PubMed Web of Science ®Google Scholar
• Saraiva SA, Silva AL, Xisto DG, Abreu SC, Silva JD, Silva PL, Teixeira TP, Parra ER, Carvalho AL, Annoni R, Mauad T, Capelozzi VL, Silva PM, Martins MA, Rocco PR: Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma. Respir Physiol Neurobiol. 2011 Jul 31;177(2):141–148.
   PubMed Web of Science ®Google Scholar
• Johnston RA, Zhu M, Rivera-Sanchez YM, Lu FL, Theman TA, Flynt L, Shore SA: Allergic airway responses in obese mice. Am J Respir Crit Care Med. 2007 Oct 1;176(7):650–658.
   PubMed Web of Science ®Google Scholar
• Brewer JP, Kisselgof AB, Martin TR: Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. Am J Respir Crit Care Med. 1999 Oct;160(4): 1150–1156.
   PubMed Web of Science ®Google Scholar
• Barros R, Moreira A, Fonseca J, Moreira P, Fernandes L, de Oliveira JF, : Obesity and airway inflammation in asthma. Journal of Allergy and Clinical Immunology. 2006; 117(6):1501–1502.
   PubMed Web of Science ®Google Scholar
• Krug N, Rabe KF: Animal models for human asthma: the perspective of a clinician. Current Drug Targets. 2008; 9(6):438–442.
   PubMed Web of Science ®Google Scholar
• Ramalho R, Soares R, Couto N, Moreira A:. Tachykinin receptors antagonism for asthma: a systematic review. BMC Pulm Med. 2011 2 August;11:1–7.
   PubMedGoogle Scholar