Time course of early histopathological lung changes in an ovine model of acute lung injury and pulmonary infection

REFERENCES

• Murakami K, Bjertnaes LJ, Schmalstieg FC, McGuire R, Cox RA, Hawkins HK, Herndon DN, Traber LD, Traber DL: A novel animal model of sepsis after acute lung injury in sheep. Crit Care Med. 2002;30:2083–2090.
   PubMed Web of Science ®Google Scholar
• Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, McGuire R, Schmalstieg F, Cox R, Hawkins H, Jodoin J, Lee S, Traber L, Herndon D, Traber D: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. Am J Physiol Regul Integr Comp Physiol. 2003;285:R366–R372.
   PubMed Web of Science ®Google Scholar
• Lange M, Connelly R, Traber DL, Hamahata A, Cox RA, Nakano Y, Bansal K, Esechie A, von Borzyskowski S, Jonkam C, Traber LD, Hawkins HK, Herndon DN, Enkhbaatar P: Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury. Crit Care Med. 2009;37:223–229.
   PubMed Web of Science ®Google Scholar
• Lange M, Connelly R, Traber DL, Hamahata A, Nakano Y, Esechie A, Jonkam C, von Borzyskowski S, Traber LD, Schmalstieg FC, Herndon DN, Enkhbaatar P: Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model. Crit Care. 2010;14:R129.
   Web of Science ®Google Scholar
• Lange M, Hamahata A, Enkhbaatar P, Esechie A, Connelly R, Nakano Y, Jonkam C, Cox RA, Traber LD, Herndon DN, Traber DL: Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis. Crit Care Med. 2008;36:1284–1289.
   PubMed Web of Science ®Google Scholar
• Maybauer MO, Maybauer DM, Fraser JF, Traber LD, Westphal M, Enkhbaatar P, Cox RA, Huda R, Hawkins HK, Morita N, Murakami K, Mizutani A, Herndon DN, Traber DL: Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis. Crit Care Med. 2006;34:2432–2438.
   PubMed Web of Science ®Google Scholar
• Murakami K, McGuire R, Cox RA, Jodoin JM, Schmalstieg FC, Traber LD, Hawkins HK, Herndon DN, Traber DL: Recombinant antithrombin attenuates pulmonary inflammation following smoke inhalation and pneumonia in sheep. Crit Care Med. 2003;31:577–583.
   PubMed Web of Science ®Google Scholar
• Narimanbekov IO, Rozycki HJ: Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in a rabbit model. Exp Lung Res. 1995;21:239–254.
   PubMed Web of Science ®Google Scholar
• Cox RA, Burke AS, Soejima K, Murakami K, Katahira J, Traber LD, Herndon DN, Schmalstieg FC, Traber DL, Hawkins HK: Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Respir Cell Mol Biol. 2003;29:295–302.
   PubMed Web of Science ®Google Scholar
• Lange M, Hamahata A, Traber DL, Connelly R, Nakano Y, Traber LD, Schmalstieg FC, Herndon DN, Enkhbaatar P: Pulmonary microvascular hyperpermeability and expression of vascular endothelial growth factor in smoke inhalation- and pneumonia-induced acute lung injury. Burns. 2012;38:1072–1078.
   PubMed Web of Science ®Google Scholar
• Kimura R, Traber LD, Herndon DN, Linares HA, Lübbesmeyer HJ, Traber DL: Increasing duration of smoke exposure induces more severe lung injury in sheep. J Appl Physiol. 1988;64:1107–1113.
   PubMed Web of Science ®Google Scholar
• Lange M, Szabo C, Traber DL, Horvath E, Hamahata A, Nakano Y, Traber LD, Cox RA, Schmalstieg FC, Herndon DN, Enkhbaatar P: Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis. Shock. 2012;37:468–472.
   PubMed Web of Science ®Google Scholar
• Lange M, Cox RA, Enkhbaatar P, Whorton EB, Nakano Y, Hamahata A, Jonkam C, Esechie A, von Borzyskowski S, Traber LD, Traber DL: Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury. Exp Lung Res. 2011;37:239–245.
   PubMed Web of Science ®Google Scholar
• Gunther A, Mosavi P, Heinemann S, Ruppert C, Muth H, Markart P, Grimminger F, Walmrath D, Temmesfeld-Wollbruck B, Seeger W: Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2000;161:454–462.
   PubMed Web of Science ®Google Scholar
• Enkhbaatar P, Murakami K, Traber LD, Cox R, Parkinson JF, Westphal M, Esechie A, Morita N, Maybauer MO, Maybauer DM, Burke AS, Schmalstieg FC, Hawkins HK, Herndon DN, Traber DL: The inhibition of inducible nitric oxide synthase in ovine sepsis model. Shock. 2006;25:522–527.
   PubMed Web of Science ®Google Scholar
• Enkhbaatar P, Joncam C, Traber L, Nakano Y, Wang J, Lange M, Connelly R, Kulp G, Saunders F, Huda R, Cox R, Schmalstieg F, Herndon D, Traber D: Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis. Shock. 2008;29:642–649.
   PubMed Web of Science ®Google Scholar
• Shirani KZ, Pruitt BA, Jr., Mason AD, Jr.: The influence of inhalation injury and pneumonia on burn mortality. Ann Surg. 1987;205:82–87.
   PubMed Web of Science ®Google Scholar
• Lange M, Hamahata A, Traber DL, Nakano Y, Esechie A, Jonkam C, Whorton EB, von Borzyskowski S, Traber LD, Enkhbaatar P: Effects of early neuronal and delayed inducible nitric oxide synthase blockade on cardiovascular, renal, and hepatic function in ovine sepsis. Anesthesiology. 2010;113:1376–1384.
   PubMed Web of Science ®Google Scholar
• Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, Komjati K, Pacher P, Zsengeller Z, Szabo C, Traber DL: Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock. 2004;21:126–133.
   PubMed Web of Science ®Google Scholar
• Lange M, Hamahata A, Enkhbaatar P, Cox RA, Nakano Y, Westphal M, Traber LD, Herndon DN, Traber DL: Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury. Shock. 2011;35:626–631.
   PubMed Web of Science ®Google Scholar
• Cox RA, Mlcak RP, Chinkes DL, Jacob S, Enkhbaatar P, Jaso J, Parish LP, Traber DL, Jeschke MG, Herndon DN, Hawkins HK: Upper airway mucus deposition in lung tissue of burn trauma victims. Shock. 2008;29:356–361.
   PubMed Web of Science ®Google Scholar