Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion

References

• Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN2012. Int. J. Canc. J. Int. du. Canc 2015;136(5):E359–E386. Epub 2014/09/16.
   Google Scholar
• American Cancer Society. [cited 2015 April2]; Available from: http://www.cancer.gov.
   Google Scholar
• Schottenfeld D. Etiology and epidemiology of lung cancer. In: Pass HI, Mitchell JB, Johnson DH, Turrisi AT, Minna JD, editors. Lung Cancer—Principles and Practice. 2nd ed. Philadelphia: Lippincott Williams and Wilkins; 2000. 367–388.
   Google Scholar
• Bach PB, Mirkin JN, Oliver TK, Azzoli CG, Berry DA, Brawley OW, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA 2012;307(22):2418–2429. Epub 2012/05/23.
   PubMed Web of Science ®Google Scholar
• Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat. Med 2007;13(3):361–366. Epub 2007/03/06.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Rondini EA. Review paper: the role of inflammation in mouse pulmonary neoplasia. Vet. Pathol 2009;46(3):369–390.
   PubMed Web of Science ®Google Scholar
• Malkinson AM. Role of inflammation in mouse lung tumorigenesis: A review. Exp. Lung. Res 2005;31(1):57–82. Epub 2005/03/16.
   PubMed Web of Science ®Google Scholar
• Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420(6917):860–867.
   PubMed Web of Science ®Google Scholar
• Homma S, Sagawa Y, Komita H, Koido S, Nagasaki E, Ryoma Y, et al. Mechanism of antitumor effect on mouse hepatocellular carcinoma by intratumoral injection of OK-432, a streptococcal preparation. Canc. Immuno. Immunother. 2007;56(8):1265–1274. Epub 2007/01/16.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Malkinson AM, Kleeberger SR. Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities. Am. J. Physiol 2004;287(4):L685–L703.
   Google Scholar
• Malkinson AM. Molecular comparison of human and mouse pulmonary adenocarcinomas. Exp. Lung. Res 1998;24(4):541–555.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Dwyer-Nield LD, Hankin JA, Murphy RC, Malkinson AM. The lung tumor promoter, butylatedhydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice. Toxicology 2001;169(1):1–15.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Dwyer-Nield LD, Keil K, Koski K, Malkinson AM. Butylatedhydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion. Exp. Lung. Res 2001;27(3):197–216.
   PubMed Web of Science ®Google Scholar
• Malkinson AM, Koski KM, Evans WA, Festing MF. Butylatedhydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene. Canc. Res 1997;57(14):2832–2834.
   PubMed Web of Science ®Google Scholar
• Vikis HG, Gelman AE, Franklin A, Stein L, Rymaszewski A, Zhu J, et al. Neutrophils are required for 3-methylcholanthrene-initiated, butylatedhydroxytoluene-promoted lung carcinogenesis. Mol. Carcinogen 2012;51(12):993–1002. Epub 2011/10/19.
   PubMed Web of Science ®Google Scholar
• Witschi H, Malkinson AM, Thompson JA. Metabolism and pulmonary toxicity of butylatedhydroxytoluene (BHT). Pharmacol. Ther 1989;42(1):89–113.
   PubMed Web of Science ®Google Scholar
• Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, et al. Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Front. Immunol 2014;5:587. Epub 2014/12/17.
   PubMedGoogle Scholar
• Keith RL, Miller YE. Lung cancer chemoprevention: current status and future prospects. Nat. Rev. Clin. On 2013;10(6):334–343. Epub 2013/05/22.
   Google Scholar
• Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282(5396):2085–2088.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Rondini EA, Hummel KA, Degraff LM, Walker C, Jedlicka AE, et al. Identification of candidate genes downstream of TLR4 signaling after ozone exposure in mice: a role for heat-shock protein 70. Environ. Health Per 2011;119(8):1091–1097. Epub 2011/05/06.
   PubMed Web of Science ®Google Scholar
• Kleeberger SR, Reddy S, Zhang LY, Jedlicka AE. Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am. J. Resp. Cell Molec. Biol 2000;22(5):620–627.
   PubMed Web of Science ®Google Scholar
• Kleeberger SR, Reddy SP, Zhang LY, Cho HY, Jedlicka AE. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am. J. Physiol 2001;280(2):L326–L333.
   Google Scholar
• Faure K, Sawa T, Ajayi T, Fujimoto J, Moriyama K, Shime N, et al. TLR4 signaling is essential for survival in acute lung injury induced by virulent Pseudomonas aeruginosa secreting type III secretory toxins. Respir. Res 2004;5(1):1.
   PubMedGoogle Scholar
• Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, et al. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J. Immunol 2005;175(8):4834–4838.
   PubMed Web of Science ®Google Scholar
• Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med 2002;347(12):869–877. Epub 2002/09/20.
   PubMed Web of Science ®Google Scholar
• Astrakianakis G, Seixas NS, Ray R, Camp JE, Gao DL, Feng Z, et al. Lung cancer risk among female textile workers exposed to endotoxin. J. Nat. Canc. Inst 2007;99(5):357–364.
   PubMedGoogle Scholar
• Lundin JI, Checkoway H. Endotoxin and cancer. Environ. Health Per 2009;117(9):1344–1350.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Dixon D, DeGraff LM, Cho HY, Walker CR, Malkinson AM, et al. Toll-like receptor 4 in butylatedhydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J. Nat. Canc. Inst 2005;97(23):1778–1781.
   PubMedGoogle Scholar
• Bauer AK, Fostel J, Degraff LM, Rondini EA, Walker C, Grissom SF, et al. Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis. Mol. Canc 2009;8:107.
   PubMedGoogle Scholar
• Hill T, 3rd, Osgood RS, Velmurugan K, Alexander CM, Upham BL, Bauer AK. Bronchoalveolar Lavage Fluid Utilized Ex Vivo to Validate In Vivo Findings: Inhibition of Gap Junction Activity in Lung Tumor Promotion is Toll-Like Receptor 4-Dependent. J. Mol. Biomar. Diag 2013;5(1). Epub 2014/07/19.
   PubMedGoogle Scholar
• Reynolds SD, Malkinson AM. Clara cell: progenitor for the bronchiolar epithelium. Int. J. Biochem. Cell Biol 2010;42(1):1–4. Epub 2009/09/15.
   PubMed Web of Science ®Google Scholar
• Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol 2012;13(11):1118–1128. Epub 2012/10/02.
   PubMed Web of Science ®Google Scholar
• Janssen WJ, Barthel L, Muldrow A, Oberley-Deegan RE, Kearns MT, Jakubzick C, et al. Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am. J. Resp. Crit. Care Med 2011;184(5):547–560. Epub 2011/04/08.
   PubMed Web of Science ®Google Scholar
• Chang SH, Mirabolfathinejad SG, Katta H, Cumpian AM, Gong L, Caetano MS, et al. T helper 17 cells play a critical pathogenic role in lung cancer. Proc. Nat. Acad. Sci. United States Am 2014;111(15):5664–5669. Epub 2014/04/08.
   PubMed Web of Science ®Google Scholar
• Mills CD, Ley K. M1 and M2 macrophages: the chicken and the egg of immunity. J. Innate Immun 2014;6(6):716–726. Epub 2014/08/21.
   PubMed Web of Science ®Google Scholar
• Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol 2011;11(11):723–737. Epub 2011/10/15.
   PubMed Web of Science ®Google Scholar
• Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, et al. Tumor necrosis factor-alpha accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am. J. Resp. Cell Mol. Biol 2014;50(4):825–837. Epub 2013/12/12.
   PubMed Web of Science ®Google Scholar
• Redente EF, Orlicky DJ, Bouchard RJ, Malkinson AM. Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am. J. Pathol 2007;170(2):693–708.
   PubMed Web of Science ®Google Scholar
• Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000prime reports 2014;6:13. Epub 2014/03/29.
   PubMedGoogle Scholar
• Korns D, Frasch SC, Fernandez-Boyanapalli R, Henson PM, Bratton DL. Modulation of macrophage efferocytosis in inflammation. Front. Immunol 2011;2:57. Epub 2011/01/01.
   PubMedGoogle Scholar
• Vogel SN, Wax JS, Perera PY, Padlan C, Potter M, Mock BA. Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene. Infect. Immun 1994;62(10):4454–4459.
   PubMed Web of Science ®Google Scholar
• AitYahia S, Azzaoui I, Everaere L, Vorng H, Chenivesse C, Marquillies P, et al. CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma. Am. J. Resp. Crit. Care Med 2014;189(8):899–908. Epub 2014/03/26.
   PubMed Web of Science ®Google Scholar
• Steele VE, Holmes CA, Hawk ET, Kopelovich L, Lubet RA, Crowell JA, et al. Potential use of lipoxygenase inhibitors for cancer chemoprevention. Expert Opin. Invest. Drug 2000;9(9):2121–2138.
   PubMed Web of Science ®Google Scholar
• Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, et al. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice. Exp. Lung. Res 2012;38(2):55–66. Epub 2011/12/22.
   PubMed Web of Science ®Google Scholar
• Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL, et al. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am. J. Resp. Crit Care Med 2009;179(11):1011–1121. Epub 2009/03/07.
   PubMed Web of Science ®Google Scholar
• Pryhuber GS, Huyck HL, Baggs R, Oberdorster G, Finkelstein JN. Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice. Toxicol. Sci.: Off. J. Soc. Toxicol 2003;72(1):150–157. Epub 2003/02/27.
   Google Scholar
• Malkinson AM, Miley, FB, Chichester, CH, Plopper, CG. Isolation of Nonciliated bronchiolar (Clara) epithelial cells from mouse lung. Methods Toxicol 1993;1A:123–133.
   Google Scholar
• Malkinson AM, Dwyer-Nield LD, Rice PL, Dinsdale D. Mouse lung epithelial cell lines–tools for the study of differentiation and the neoplastic phenotype. Toxicology 1997;123(1–2):53–100.
   PubMed Web of Science ®Google Scholar
• Zhang X, Goncalves R, Mosser DM. The isolation and characterization of murine macrophages.Current protocols in immunology / edited by John E Coligan [et al]. 2008; Chapter 14:Unit 14 1. Epub 2008/11/20.
   Google Scholar
• Justus CR, Leffler N, Ruiz-Echevarria M, Yang LV. In vitro cell migration and invasion assays. J. Visualized Exp 2014(88). Epub 2014/06/26.
   PubMed Web of Science ®Google Scholar
• Karabela SP, Psallidas I, Sherrill TP, Kairi CA, Zaynagetdinov R, Cheng DS, et al. Opposing effects of bortezomib-induced nuclear factor-kappaB inhibition on chemical lung carcinogenesis. Carcinogenesis 2012;33(4):859–867. Epub 2012/01/31.
   PubMed Web of Science ®Google Scholar
• Geiser M, Lay JC, Bennett WD, Zhou H, Wang X, Peden DB, et al. Effects of ex vivo gamma-tocopherol on airway macrophage function in healthy and mild allergic asthmatics. J. Innate Immun 2013;5(6):613–624. Epub 2013/05/22.
   PubMed Web of Science ®Google Scholar
• Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc. Nat. Acad. Sci. United States Am 2012;109(46):E3186–E3195. Epub 2012/10/27.
   Google Scholar
• Hollingsworth JW, Whitehead GS, Lin KL, Nakano H, Gunn MD, Schwartz DA, et al. TLR4 signaling attenuates ongoing allergic inflammation. J. Immunol 2006;176(10):5856–5862.
   PubMed Web of Science ®Google Scholar
• Ferlazzo G, Morandi B. Cross-Talks between Natural Killer Cells and Distinct Subsets of Dendritic Cells. Front. Immunol 2014;5:159. Epub 2014/05/02.
   PubMedGoogle Scholar
• Rondini EA, Walters DM, Bauer AK. Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Part. FibreToxicol 2010;7:9.
   PubMedGoogle Scholar
• Gong L, Cumpian AM, Caetano MS, Ochoa CE, De la Garza MM, Lapid DJ, et al. Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase. Mol. Canc 2013;12(1):154. Epub 2013/12/11.
   PubMedGoogle Scholar
• Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN. Canc. Cell 2009;16(3):183–194. Epub 2009/09/08.
   PubMed Web of Science ®Google Scholar
• Bauer AK, Cho HY, Miller-Degraff L, Walker C, Helms K, Fostel J, et al. Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice. PloS One 2011;6(10):e26590. Epub 2011/11/01.
   Google Scholar
• Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, et al. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 2012;150(1):165–178. Epub 2012/07/10.
   PubMed Web of Science ®Google Scholar
• Sevko A, Umansky V. Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves. J. Canc 2013;4(1):3–11. Epub 2013/02/07.
   Web of Science ®Google Scholar
• Sawant A, Schafer CC, Jin TH, Zmijewski J, Tse HM, Roth J, et al. Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways. Canc. Res 2013;73(22):6609–6620. Epub 2013/10/03.
   PubMed Web of Science ®Google Scholar
• Fritz JM, Dwyer-Nield LD, Malkinson AM. Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation. Mol. Canc 2011;10:76. Epub 2011/06/28.
   PubMedGoogle Scholar
• Zhang Q, Pan J, Lubet RA, Wang Y, You M. Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention. Mol. Carcinogen 2015;54Suppl1:E129–E137. Epub 2014/08/29.
   Google Scholar
• Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. J. Clin. Invest 2006;116(11):3050–3059. Epub 2006/10/21.
   PubMed Web of Science ®Google Scholar
• Lenters V, Basinas I, Beane-Freeman L, Boffetta P, Checkoway H, Coggon D, et al. Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers. Canc. Causes Control: CCC 2010;21(4):523–555. Epub 2009/12/17.
   Google Scholar
• Yusuf N, Nasti TH, Long JA, Naseemuddin M, Lucas AP, Xu H, et al. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Canc. Res 2008;68(2):615–622.
   PubMed Web of Science ®Google Scholar
• Yusuf N, Nasti TH, Meleth S, Elmets CA. Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis. Mol. Carcinogen 2009.
   Web of Science ®Google Scholar
• Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA, et al. A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 2007;132(3):905–912.
   PubMed Web of Science ®Google Scholar
• Muller-Decker K, Manegold G, Butz H, Hinz DE, Huttner D, Richter KH, et al. Inhibition of cell proliferation by bacterial lipopolysaccharides in TLR4-positive epithelial cells: independence of nitric oxide and cytokine release. J. Investi. Dermatol 2005;124(3):553–561. Epub 2005/03/02.
   PubMed Web of Science ®Google Scholar
• Wang Z, Yan J, Lin H, Hua F, Wang X, Liu H, et al. Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice. Hepatology 2013;57(5):1869–1881. Epub 2013/01/10.
   PubMed Web of Science ®Google Scholar
• Cheng I, Plummer SJ, Casey G, Witte JS. Toll-like receptor 4 genetic variation and advanced prostate cancer risk. Canc. Epidemiol. Biomark. Prev 2007;16(2):352–355.
   PubMed Web of Science ®Google Scholar
• Apetoh L, Ghiringhelli F, Tesniere A, Criollo A, Ortiz C, Lidereau R, et al. The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol. Rev 2007;220:47–59.
   PubMed Web of Science ®Google Scholar
• Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med 2007;13(9):1050–1059.
   PubMed Web of Science ®Google Scholar
• Balkwill F. Tumour necrosis factor and cancer. Nat. Rev. Canc 2009;9(5):361–371. Epub 2009/04/04.
   PubMed Web of Science ®Google Scholar
• Cho HJ, Jung JI, Lim do Y, Kwon GT, Her S, Park JH, et al. Bone marrow-derived, alternatively activated macrophages enhance solid tumor growth and lung metastasis of mammary carcinoma cells in a Balb/C mouse orthotopic model. Breast Canc. Res.: BCR 2012;14(3):R81. Epub 2012/05/24.
   Google Scholar
• Redente EF, Dwyer-Nield LD, Merrick DT, Raina K, Agarwal R, Pao W, et al. Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization. Am. J. Pathol 2010;176(6):2972–2985. Epub 2010/05/01.
   PubMed Web of Science ®Google Scholar
• Mastrangelo G, Fadda E, Cegolon L. Endotoxin and cancer chemo-prevention. Canc. Epidemiol 2013;37(5):528–533. Epub 2013/05/23.
   PubMed Web of Science ®Google Scholar