Advanced search
Publication Cover
Experimental Lung Research Volume 2, 1981 - Issue 1
Submit an article Journal homepage
20
Views
18
CrossRef citations to date
0
Altmetric
Original Article

Pathways of Palmitate Metabolism in the Isolated Rat Lung

David J. P. Bassett From the Departments of Physiology and Biophysics and of Pediatrics, Georgetown University, Washington, D.C. 20007 and Veterans Administration Hospital, Philadelphia, Pennsylvania, 19104; Department of Environmental Health Sciences, School of Hygiene and Public Health. The Johns Hopkins University, 615 North Wolfe St., Balimore, MD, 21205
,
Margit Hamosh From the Departments of Physiology and Biophysics and of Pediatrics, Georgetown University, Washington, D.C. 20007 and Veterans Administration Hospital, Philadelphia, Pennsylvania, 19104
,
Paul Hamosh From the Departments of Physiology and Biophysics and of Pediatrics, Georgetown University, Washington, D.C. 20007 and Veterans Administration Hospital, Philadelphia, Pennsylvania, 19104
&
Joseph L. Rabinowitz From the Departments of Physiology and Biophysics and of Pediatrics, Georgetown University, Washington, D.C. 20007 and Veterans Administration Hospital, Philadelphia, Pennsylvania, 19104
Pages 37-47 | Received 30 Jul 1980, Accepted 18 Oct 1980, Published online: 02 Jul 2009

References

  • Frosolono MF. Lung. Lipid Metabolism in Mammals, F. Snyder. Plenum, New York and London 1977; Vol. 2: 1–39
  • Tierney D F, Clement J A, Trahan HJ. Rates of replacement of lecithins and alveolar instability in rat lungs. Am J Physiol 1967; 213: 671–676
  • van Golde L MG. Metabolism of phospholipids in the lung. Am Rev Resp Dis 1976; 114: 977–1000
  • Young S L, Tierney DF. Dipalmitoyl lecithin secretion and metabolism by the rat lung. Am J Physiol 1972; 222: 1539–1544
  • Chida N, Adams FH. Incorporation of acetate into fatty acids and lecithin by lung slices from fetal and newborn lambs. J Lipid Res 1967; 8: 335–341
  • Batenburg J J, Post M, Oldenborg V, et al. The perfused isolated lung as a possible model for the study of lipid synthesis by type II cells in their natural environment. Exp Lung Res 1980; 1: 57–65
  • Godinez R I, Longmore WJ. Use of the isolated perfused rat lung in studies on lung metabolism. J Lipid Res 1973; 14: 138–144
  • Mason R J, Dobbs LG. Synthesis of phosphatidylcholine and phosphatidylglycerol by alveolar type II cells in primary culture. J Biol Chem 1980; 255: 5101–5107
  • Wang M C, Meng HC. Synthesis of phospholipids and phospholipid fatty acids by isolated perfused rat lung. Lipids 1974; 9: 63–67
  • Jobe A. An in vivo comparison of acetate and palmitate as precursors of surfactant phosphatidyl choline. Biochem Biophys Acta 1979; 572: 404–412
  • Longmore W J, Oldenborg V, van Golde L MG. Phospholipase A2 in rat lung microsomes: substrate specificity towards endogenous phosphatidyl cholines. Biochem Biophys Acta 1979; 572: 452–460
  • Bassett D JP, Fisher A B, Rabinowitz JL. Effects of hypoxia on incorporation of glucose carbons into lipids by isolated rat lung. Am J Physiol 1974; 227: 1103–1108
  • Salisbury-Murphy S, Rubinstein D, Beck JC. Lipid metabolism in the perfused lung: response to changes in circulating glucose and palmitate levels. Lipids 1977; 12: 930–935
  • Shaw M, Rhoades RA. Substrate metabolism in the perfused lung: response to changes in circulating glucose and palmitate levels. Lipids 1977; 12: 930–935
  • Darrah H K, Hedley-Whyte J. Rapid incorporation of palmitate into lungs: Site and metabolic fate. J Appl Physiol 1973; 35: 205–213
  • Naimark A, Klass D. The incorporation of palmitate-1-14C by rat lung in vitro. Can J Physiol Pharmacol 1967; 45: 596–607
  • Thomas T, Jr, Rhoades RA. Incorporation of palmitate-1-14C into lung tissue and alveolar lecithin. Am J Physiol 1970; 219: 1535–1538
  • Toshima N, Akino T. Alveolar and tissue phospholipids of rat lung. Tohoku J Exp Med 1972; 108: 253–263
  • Toshima N, Akino T, Ohno K. Turnover time of lecithin in lung tissue and alveolar wash of rat. Tohoku J Exp Med 1972; 108: 265–277
  • Frosolono M F, Slivka S, Charms BL. Acyl transferase activities in dog lung microsomes. J Lipid Res 1971; 12: 96–103
  • Gross I, Warshaw JB. Enzyme activities related to fatty acid synthesis in developing mammalian lung. Pediat Res 1974; 8: 193–199
  • Schiller H, Bensch K. De novo fatty acid synthesis and elongation of fatty acids by subcellular fractions of lung. J Lipid Res 1971; 12: 248–255
  • Bassett D JP, Fisher AB. Metabolic response to carbon monoxide by isolated rat lungs. Am J Physiol 1976; 230: 658–663
  • Bassett D JP, Fisher AB. Stimulation of rat lung metabolism with 2,4-dinitrophenol and phenazine methosulphate. Am J Physiol 1976; 231: 898–902
  • Bassett D JP, Fisher AB. Pentose cycle activity of the isolated perfused rat lung. Am J Physiol 1976; 231: 1527–1532
  • Bassett D JP, Fisher AB. Alterations of lung glucose metabolism on perfusion with paraquat. Am J Physiol 1978; 234: E653–E659
  • Jungas RL. Fatty acid synthesis in adipose tissue incubated in tritiated water. Bio-chem 1968; 7: 3708–3717
  • Lowenstein JM. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. J Biol Chem 1971; 246: 629–632
  • Folch J, Lees M, Stanley G HS. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497–509
  • Rabinowitz J L, Bailey T A, Marsh JB. Polar and neutral lipids of pig gingiva. Arch Oral Biol 1971; 16: 1195–1205
  • Yeager H, Jr, Massaro D. Glucose metabolism and glycoprotein synthesis by lung slices. J Appl Physiol 1972; 32: 477–482
  • Wykle R L, Malone B, Blank M L, et al. Biosynthesis of pulmonary surfactant Comparison of l-palmitoyl-sn-glycero-3-phosphocholine and palmitate as precursors of dipalmitoyl-sn-glycero-phosphocholine in adenoma alveolar type II cells. Arch Biochem Biophys 1980; 199: 526–537

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.