16
Views
34
CrossRef citations to date
0
Altmetric
Original Article

Response of Rat Alveolar Macrophages to Ozone: Quantitative Assessment of Population Size, Morphology, and Proliferation following Acute Exposure

, , &
Pages 1-16 | Received 04 Oct 1987, Accepted 22 Feb 1988, Published online: 02 Jul 2009

References

  • Schwartz L W, Dungworth D L, Mustafa M G, Tarkington B K, Tyler W S. Pulmonary responses of rats to ambient levels of ozone: Effects of 7-day intermittent or continuous exposure. Lab Invest 1976; 34: 565–578
  • Stephens R J, Sloan M F, Evans M J, Freeman G. Early response of lung to low levels of ozone. Am J Pathol 1974; 74: 31–58
  • Plopper C G, Dungworth D L, Tyler W S. Pulmonary lesions in rats exposed to ozone. A correlated light and electron microscopic study. Am J Pathol 1973; 71: 375–394
  • Boatman E S, Frank R. Morphologic and ultrastructural changes in the lungs of animals during acute exposure to ozone. Chest 1974; 65(4)9S–11S
  • Lum H., Tyler W S, Hyde D M, Plopper C G. Morphometry of in situ and lavaged pulmonary alveolar macrophages from control and ozone-exposed rats. Exp Lung Res 1983; 5: 61–78
  • Coffin D L, Gardner D E, Holzman R S, Wolock F J. Influence of ozone on pulmonary cells. Arch Environ Health 1968; 16: 633–636
  • Brummer M EG, Schwartz L W, McQuillen N K. A quantitative study of lung damage by scanning electron microscopy. Inflammatory cell response to high-ambient levels of ozone. Scanning Electron Microsc 1977; 2: 513–518
  • Castleman W L, Dungworth D L, Schwartz L W, Tyler W S. Acute respiratory bron-chiolitis: An ultrastructural and autoradiographic study of epithelial cell injury and renewal in rhesus monkeys exposed to ozone. Am J Pathol 1980; 98: 811–840
  • Huber G L, Mason R J, LaForce M., Spencer N J, Gardner D E, Coffin D L. Alterations in the lung following the administration of ozone. Arch Inter Med 1971; 128: 81–87
  • Bowden D H, Adamson I YR. The pulmonary interstitial cell as immediate precursor of the alveolar macrophage. Am J Pathol 1972; 68: 521–536
  • Bitterman P B, Saltzman L E, Adelberg S., Ferrans V J, Crystal R G. Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflammed lung. J Clin Invest 1984; 74: 460–469
  • Evans M J, Shami S G, Martinez L A. Enhanced proliferation of pulmonary alveolar macrophages after carbon instillation in mice depleted of blood monocytes by strontium-89. Lab Invest 1986; 54: 154–159
  • Evans M J, Cabral L J, Stephens R J, Freeman G. Cell division of alveolar macrophages in rat lung following exposure of NO2. Am J Pathol 1973; 70: 199–208
  • Lin H., Kuhn C., Kuo T. Clonal growth of hamster free alveolar cells in soft agar. J Exp Med 1975; 142: 877–885
  • Tarling J D, Coggle J E. Evidence for the pulmonary origin of alveolar macrophages. Cell Tissue Kinet 1982; 15: 577–584
  • Shellito J., Esparaza C., Armstrong C. Maintenance of the normal rat alveolar macrophage cell population: The roles of monocyte influx and alveolar macrophage proliferation in situ. Am Rev Respir Dis 1987; 135: 78–82
  • Evans M J, Sherman M P, Campbell L A, Shami S G. Proliferation of pulmonary alveolar macrophages during postnatal development of rabbit lungs. Am Rev Respir Dis 1987; 136: 384–387
  • Golde D., Bylers L., Finley T. Proliferative capacity of human alveolar macrophages. Nature 1974; 247: 373–375
  • Aherne W A, Camplejohn R S, Wright N A. Introduction to Cell Population Kinetics. Edward Arnold Ltd., London 1977
  • Zitnik L A, Schwartz L W, McQuillen N K, Zee Y C, Osebold J W. Pulmonary changes induced by low-level ozone: Morphological observations. J Environ Pathol Toxicol 1978; 1(4)365–376
  • Plopper C G, Chow C K, Dungworth D L, Brummer M., Nemeth T J. Effect of low level of ozone on rat lungs. II. Morphological responses during recovery and re-exposure. Exp Mol Pathol 1978; 29: 400–411
  • Evans M J, Johnson L V, Stephens R J, Freeman G. Cell renewal in the lungs of rats exposed to low levels of ozone. Exp Mol Pathol 1976; 24: 70–83
  • Boorman G A, Schwartz L W, Dungworth D L. Pulmonary effects of prolonged ozone insult in rats. Lab Invest 1980; 43: 108–115
  • Evans M J, Dekker N P, Cabral-Anderson L J, Shami S G. Morphological basis of tolerance to ozone. Exp Mol Pathol 1985; 42: 366–376
  • Barry B E, Miller F J, Crapo J D. Effects of inhalation of 0.12 and 0.25 parts per million ozone on the proximal alveolar region of juvenile and adult rats. Lab Invest 1985; 53: 692–704
  • Brain J D. Free cells in the lung: Some aspects of their role, quantitation and regulation. Arch Intern Med 1970; 126: 477–487
  • Alpert S M, Gardner D E, Hurst D J, Lewis T R, Coffin D L. Effects of exposure to ozone on defensive mechanisms of the lung. J Appl Physiol 1971; 31: 247–252
  • Dowell A R, Lohrbauer L A, Hurst D., Lee S D. Rabbit alveolar macrophage damage caused by in vivo ozone inhalation. Arch Environ Health 1970; 21: 121–127
  • Driscoll K E, Vollmuth T A, Schlesinger R B. Acute and subchronic ozone inhalation in the rabbit: Responses of alveolar macrophages. J Toxicol Environ Health 1987; 21: 27–43
  • Brain J D, Godleski J J, Sorokin S P. Quantification, origin, and fate of pulmonary macrophages. Respiratory Defense Mechanisms, Part II, J D Brain, D F Proctor, L M Reid. Marcel Dekker, New York 1977
  • Boorman G A, Schwartz L W, Wilson F D. In vitro macrophage colony formation by free lung cells during pulmonary injury. J Reticuloendothel Soc 1979; 26: 867–872
  • Lewis D J, Edmondson N A, Pretice D E. A quantitative ultrastructural comparison of macrophages from rats exposed to smoke derived from conventional tobacco and a tobacco substitute. Toxicol Lett 1980; 5: 83–87
  • Matulionis D H, Traurig H H. In situ response of lung macrophages and hydrolase activity to cigarette smoke. Lab Invest 1977; 37: 314–326
  • Chen S., Weller M A, Barnhart M I. Effects of diesel exhaust on pulmonary alveolar macrophages. Scanning Electron Microscopy/1980/111. AMF O'Hare, O Johari, R P Becker. Scanning Electron Microscopy, Inc., Chicago, IL 1980
  • Boorman G A, Schwartz L W, Wilson F D. Formation of macrophage colonies in vitro by free lung cells obtained from rats. J Reticuloendothel Soc 1979; 26: 855–866
  • Wright E S, White D M, Brady A N, Li L C, D'Arcy J B, Smiler K L. DNA synthesis in pulmonary alveolar macrophages and type II cells: Effects of ozone exposure and treatment with α-defluoromethylornithine. J Toxicol Environ Health 1987; 21: 15–16
  • Seltzer J., Bigby B G, Stulbarg M., Holtzman M J, Nadel J A, Ueki I F, Leikauf G P, Geotzl E J, Boushey H A. Ozone-induced change in bronchial reactivity to metha-choline and airway inflammation in humans. J Appl Physiol 1986; 60: 1320–1326
  • Bitterman P B, Renard S I, Crystal R G. Environmental lung disease and the inter-stitium. Chest Med 1981; 2: 393–412
  • Doherty D E, Clark R AF, Henson P M. Neutrophil dependence of monocyte accumulation in the rabbit lung. Am Rev Respir Dis 1987; 135(4)A335

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.