Response of Rat Lungs to Amiodarone: Preferential Accumulation of Amiodarone and Desethylamiodarone in Alveolar Macrophages

References

• Zipes D P, Prystowsky E N, Heger J J. Amiodarone electrophysiologic actions, pharmacokinetics and clinical effects. J Am Coll Cardiol 1984; 3: 1059–1071
   PubMed Web of Science ®Google Scholar
• Singh B N, Venkatesh N, Nademanee K, Josephson M A, Kannan R. The historical development, cellular electrophysiology and pharmacology of amiodarone. Prog Cardiovasc Dis 1989; 31: 249–280
   PubMed Web of Science ®Google Scholar
• Mason J W. Medical intelligence: Drug therapy, amiodarone. N Eng J Med 1987; 316: 455–466
   PubMed Web of Science ®Google Scholar
• Akoun G M, Liote H, Milleron B J, Mayaud C M. Amiodarone lung. Current Topics in Pulmonary Pharmacology and Toxicology, vol. 2, M A Hollinger. Elsevier, New York 1987; 176–194
   Google Scholar
• Riva E, Marchi S, Pesenti A, Bizzi A, Cini M, Veneroni E, Tavbani E, Boeri R, Bertani T, Latini R. Amiodarone induced phospholipidosis: Biochemical, morphological and functional changes in the lungs of rats chronically treated with amiodarone. Biochem Pharmacol 1987; 36: 3209–3214
   PubMed Web of Science ®Google Scholar
• Reasor M J, Ogle C L, Kacew S. Amiodarone-induced pulmonary toxicity in rats: Biochemical and pharmacological characteristics. Toxicol Appl Pharmacol 1989; 97: 124–133
   PubMed Web of Science ®Google Scholar
• Martin WJ I, Standing J E. Amiodarone pulmonary toxicity: Biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects. J Pharmacol Exp Ther 1988; 244: 774–779
   PubMed Web of Science ®Google Scholar
• Brien J F, Jimmo S, Brennan F J, Ford S E, Armstrong P W. Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues. Can J Phys Pharmacol 1987; 65: 360–364
   PubMed Web of Science ®Google Scholar
• Heath M F, Costa-Jussa F R, Jacobs J M, Jacobson W. The induction of pulmonary phospholipidosis and the inhibition of lysosomal phospholipases by amiodarone. Br J Exp Pathol 1985; 66: 391–397
   PubMed Web of Science ®Google Scholar
• Hostetler K Y, Giordano J R, Jellison E J. In vitro inhibition of lysosomal phos-pholipase A! of rat lung by amiodarone and desethylamiodarone. Biochem Biophys Acta 1988; 959: 316–321
   PubMed Web of Science ®Google Scholar
• Colgan T, Simon G T, Kay J, Pugsley S O, Eydt J. Amiodarone pulmonary toxicity. Ultrastructural Pathol 1984; 6: 199–207
   PubMed Web of Science ®Google Scholar
• Marchlinski F E, Gansler T S, Waxman H L, Josephson M E. Amiodarone pulmonary toxicity. Ann Intern Med 1982; 97: 839–845
   PubMed Web of Science ®Google Scholar
• Reasor M J, Ogle C L, Walker E R, Kacew S. Amiodarone-induced phospholipidosis in rat alveolar macrophages. Am Rev Respir Dis 1988; 137: 510–518
   PubMed Web of Science ®Google Scholar
• Fan K, Bell R, Eudy S, Fullenwider J. Amiodarone-associated pulmonary fibrosis: Evidence of an immunologically mediated mechanism. Chest 1987; 92: 625–630
   PubMed Web of Science ®Google Scholar
• Akoun G M, Gauthier-Rahman S, Milleron B J, Perrot J Y, Mayaud C M. Amiodarone-induced hypersensitivity pneumonitis. Evidence of an immunological cell-mediated mechanism. Chest 1984; 85: 133–135
   PubMed Web of Science ®Google Scholar
• Martin W J, Howard D M. Amiodarone-iduced lung toxicity. In vitro evidence for the direct toxicity of the drug. Am J Pathol 1985; 120: 344–350
   PubMed Web of Science ®Google Scholar
• Costa-Jussa F R, Corrin B, Jacobs J M. Amiodarone lung toxicity: A human and experimental study. J Pathol 1984; 143: 73–79
   Google Scholar
• Myers J L, Kennedy J I, Plumb V J. Amiodarone lung: Pathologic findings in clinically toxic patients. Hum Pathol 1987; 18: 349–354
   PubMed Web of Science ®Google Scholar
• Rotmensch H H, Belhassen B, Swanson B N, Shoshani D, Spielman S R, Green-Spon A J, Greenspan A M, Vlasses P H, Horowitz L N. Steady-state serum amiodarone concentrations: Relationships with antiarrhythmic efficacy and toxicity. Ann Intern Med 1984; 101: 462–469
   PubMed Web of Science ®Google Scholar
• Jones G S, Miles P R, Lantz R C, Hinton D E, Castranova V. Ionic content and regulation of cellular volume in rat alveolar type II cells. J Appl Physiol 1982; 53: 258–266
   PubMed Web of Science ®Google Scholar
• Castranova V, Wright J R, Colby H D, Miles P R. Ascorbate uptake by isolated rat alveolar macrophages and type II cells. J Appl Physiol 1984; 54: 208–214
   Web of Science ®Google Scholar
• Folch J, Lees M, Sloane Stanley G H. A simple method for the isolation and purification of total lipides from animal tissue. J Biol Chem 1957; 226: 497–509
   PubMed Web of Science ®Google Scholar
• Ames B N, Dubin D T. The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem 1960; 235: 769–775
   PubMed Web of Science ®Google Scholar
• Tallarida R J, Murray R B. Manual of pharmacologic Calculations with Computer Programs. Springer-Verlag, New York 1981
   Google Scholar
• Sjostrom K, Crapo J D. Structural and biochemical adaptive changes in rat lungs after exposure to hypoxia. Lab Invest 1983; 48: 68–79
   PubMed Web of Science ®Google Scholar
• Lullmann H, Lullmann-Rauch R, Wasserman O. Lipidosis induced by amphophilic cationic drugs. Biochem Pharmacol 1978; 27: 1103–1108
   PubMed Web of Science ®Google Scholar
• Hostetler K Y. Molecular studies of the induction of cellular phospholipidosis by cationic amphiphilic drugs. Fed Proc 1984; 43: 2582–2585
   PubMedGoogle Scholar
• Nichols B. Normal rabbit alveolar macrophages. I. The phagocytosis of tubular myelin. J Cell Biol 1976; 67: 906–919
   Google Scholar
• Desai R, Tetley T D, Curtis C G, Powell G M, Richards R J. Studies on the fate of surfactant in the lung. Biochem J 1978; 176: 455–462
   PubMed Web of Science ®Google Scholar
• Miles P R, Ma J YC, Bowman L. Degradation of pulmonary surfactant disatura-ted phophatidylcholines by alveolar macrophages. J Appl Physiol 1988; 64: 2474–2481
   PubMed Web of Science ®Google Scholar
• Heyneman C A, Reasor M J. Role of the alveolar macrophage in the induction of pulmonary phospholipidosis by chlorphentermine. 1. Drug and phospholipid levels. J Pharmacol Exp Ther 1986; 236: 55–59
   PubMed Web of Science ®Google Scholar
• Ma J YC, Ma J KH, Weber K, Bowman L, Reasor M J, Miles P R. Association of chlorphentermine with phospholipids in rat alveolar lavage materials, alveolar macrophages and type II cells. Biochim Biophys Acta 1988; 958: 163–171
   PubMed Web of Science ®Google Scholar