References
- Forkert P G, Parkinson A, Thaete L G, Malkinson A M. Resistance of murine lung tumors to xenobiotic-induced cytotoxicity. Cancer Res. 1992; 52: 6797–6803
- Forkert P G, Reynolds E S. 1,1-Dichloroethylene-induced pulmonary injury. Exp Lung Res. 1982; 3: 57–68
- Lee R P, Forkert P G. Pulmonary CYP2E1 bioactivates 1,1-dichloroethylene in male and female mice. J Pharmacol Exp Ther. 1995; 273: 561–567
- Forkert P G, Stringer V, Troughton K M. Pulmonary toxicity of 1,1-dichloroethylene: correlation of early changes with covalent binding. Can J Physiol Pharmacol. 1986; 64: 112–121
- Forkert P G, Hofley M, Racz W J. Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes. Can J Physiol Pharmacol. 1987; 65: 1496–1499
- Okine L K, Gram T E. In vitro studies on the metabolism and covalent binding of [14C] 1,1-dichloroethylene by mouse liver, kidney and lung. Biochem Pharmacol. 1986; 35: 2789–2795
- Moussa M, Forkert P G. 1,1-Dichloroethylene-induced alterations in glutathione and covalent binding in murine lung: morphological, histochemical and biochemical studies. J Pathol. 1992; 166: 199–207
- Dowsley T F, Forkert P G, Benesch L A, Bolton J L. Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene. Chem-Biol Interact. 1995; 95: 227–244
- Liebler D C, Meredith M J, Guengerich F P. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in micrososmes and isolated hepatocytes. Cancer Res. 1985; 45: 186–193
- Liebler D C, Latwesen D G, Reeder T C. S- (2-Chloroacetyl) glutathione, a reactive thiol ester and putative metabolite of 1,1-dichloroethylene. Biochemistry. 1988; 27: 3652–3657
- Costa A K, Ivanetich K M. Chlorinated ethylenes: their metabolism and effect on DNA repair in hepatocytes. Carcinogenesis. 1984; 5: 1629–1636
- Dowsley T F, Ulreich J B, Bolton J L, Park S S, Forkert P G. CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates. Toxicol Appl Pharmacol. 1996; 139: 42–48
- Forkert P G, Lee R P, Dowsley T F, Hong J -Y, Ulreich J B. Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic. J Pharmacol Exp Ther. 1996; 277: 1665–1671
- Forkert P G, Collins K, Dowsley T F, Ross G M. Immunochemical assay for recognition of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene-epoxide. J Pharmacol Exp Ther. 1997; 281: 1422–1430
- Forkert P G. CYP2E1 is preferentially expressed in Clara cells of murine lung: localization by in situ hybridization and immunohistochemical methods. Am J Respir Cell Mol Biol. 1995; 12: 589–596
- Malkinson A M. Genetic studies on lung tumor susceptibility and histogenesis in mice. Environ Health Perspect. 1991; 93: 149–159