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Ultrastructural Pathology Volume 18, 1994 - Issue 3
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Original Article

Microtubular Discontinuities as Acquired Ciliary Defects in Airway Epithelium of Patients with Chronic Respiratory Diseases

Johnny L. Carson Department of Pediatrics and Cell Biology and Anatomy and the Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
,
Albert M. Collier Department of Pediatrics, the Frank Porter Graham Child Development Center and the Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
,
Gerald W. Fernald Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
&
Shih-Chin S. Hu Department of Pediatrics and the Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Pages 327-332 | Accepted 13 Jul 1993, Published online: 10 Jul 2009

References

  • Afzelius BA. A human syndrome caused by immotile cilia. Science 1976; 193: 317–319
  • Pedersen H, Mygind N. Absence of axonemal arms in nasal mucosa cilia in Kartagener's syndrome. Nature (London) 1976; 262: 494–495
  • Siewert A. Uber einen Fall von Bronchiektasie bei einem Patienten mit situs inversus viscerum. Berl Klin Wochenschr. 1904; 41: 139–141
  • Kartagener M. Zur Pathogenese der Bronchiektasien. Beitr Klin Tuberk. 1993; 83: 489–501
  • Sturgess JM, Chao J, Wong J, Aspin N, Turner JAP. Cilia with defective radial spokes: a cause of human respiratory disease. N Engl J Med. 1979; 303: 53–56
  • Sturgess JM, Chao J, Turner JAP. Transposition of ciliary microtubules: another cause of impaired ciliary motility. N Engl J Med. 1980; 303: 318–322
  • Rutland J, de longh RU. Random ciliary orientation: a cause of respiratory tract disease. N Engl J Med. 1990; 323: 1681–1684
  • Sleigh MA. Primary ciliary dyskinesia. Lancet. 1981; 2: 476
  • Carson JL, Collier AM, Hu SS. The appearance of compound cilia in the nasal mucosa of normal human subjects in response to acute, low level sulfur dioxide exposure. Environ Res. 1987; 42: 155–165
  • Ranga V, Kleinerman J. A quantitative study of ciliary injury in the small airways of mice: the effects of nitrogen dioxide. Exp Lung Res. 1981; 164: 49–55
  • Carson JL, Collier AM, Hu SS. Acquired ciliary defects in nasal respiratory epithelium of children with acute viral upper respiratory infections. N Engl J Med. 1985; 312: 463–468
  • Howell JT, Schochet SS, Goldman AS. Ultrastructural defects of respiratory tract cilia associated with chronic infections. Arch Pathol Lab Med. 1980; 104: 52–55
  • Wilsman NJ, Morrison WB, Farnum CE, Fox LE. Microtubular protofilaments and subunits of the outer dynein arm in cilia from dogs with primary ciliary dyskinesia. Am Rev Respir Dis. 1987; 135: 137–143
  • Torikata C, Kawai T, Nogawa S, Ikeda K, Shimizu K, Kijimoto C. Nine Japanese patients with immotile-dyskinetic cilia syndrome. Hum Pathol. 1991; 22: 830–836
  • Alford BR, Douglas RG, Jr, Couch RB. Atraumatic biopsy of nasal mucosa. Arch Otolaryngol. 1969; 90: 180–184
  • Carson JL, Collier AM, Henshaw NG, Smith CA, Hu SS. Response of human ciliated respiratory epithelium to brief in vivo ozone exposure: an ultrastructural study. Environ Res. 1985; 37: 212–227
  • Schneeberger EE, McCormack J, Issenberg HJ, Schuster SR, Gerald PS. Heterogeneity of ciliary morphology in the immotile-cilia syndrome in man. J Ultrastr Res. 1980; 73: 34–43
  • Smallman LA, Gregory J. Ultrastructural abnormalities of cilia in the human respiratory tract. Hum Pathol. 1986; 17: 848–855
  • Fox B, Bull TB, Makey AR, Rawbone R. The significance of ultrastructural abnormalities of human cilia. Chest. 1981; 80: 796–799

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