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Original Article

Injectable nanospheres from a novel multiblock copolymer: Cytocompatibility, degradation and in vitro release studies

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Pages 745-758 | Received 20 Feb 2003, Accepted 28 May 2003, Published online: 02 Jul 2010

References

  • Allemann E., Gurny R., Leroux J. C. Biodegradable nanoparticles of poly (lactic acid) for parenteral administration. Pharmaceutical Dosage Forms: Disperse Systems, H. A. Lieberman, M. M. Riegen, G. S. Banker. Marcel Dekker, New York 1998; Vol. 3: 163–193
  • Atkins T. W., Peacock S. J. The incorporation and release of bovine serum albumin from polyhydroxybutyrate microcapsules. Journal of Microencapsuation 1996; 13: 709–717
  • Barrett E. P., Joyner L. G., Halenda P. P. J. The determination of pore volume and area distributions in porous substances. I. Computations from nitrogen isotherms. Journal of American Chemical Society 1951; 73: 373–380
  • Belbella A., Vauthier C., Fessi H., Devissaguet J. P., Puissieux F. In vitro degradation of nanospheres from poly(dl-lactides) of different molecular weights and polydispersities. International Journal of Pharmaceutics 1996; 129: 95–102
  • Beletsi A., Leontiadis L., Klepetsanis P., Ithakissios D. S., Avgoustakis K. Effect of preparative variables on the properties of poly (dl-lactide-co-glycolide)-methoxypoly (ethyleneglycol) copolymers related to their application in controlled drug delivery. International Journal of Pharmaceutics 1999; 18: 187–197
  • Bodmeier R., Maincent P. Polymeric dispersions as drug carriers. Pharmaceutical Dosage Forms: Disperse Systems, H. A. Lieberman, M. M. Riegen, G. S. Banker. Marcel Dekker, New York 1998; Vol. 3: 87–127
  • Brannon-Peppas L. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. International Journal of Pharmaceutics 1995; 116: 1–9
  • Cohn D., Younes H. Biodegradable PEO/PLA block copolymers. Journal of Biomedical Material Research 1988; 22: 993–1009
  • De Jaeghere F., Allemann E., Leroux J. C., Stevels W., Feijen J., Doelker E., Gurny R. Formulation and lyoprotection of poly (lactic acid-co-ethylene oxide) nanoparticles: influence on physical stability and in vitro cell uptake. Pharmaceutical Research 1999; 16: 859–866
  • Gref R., Minamitake Y., Peracchia M. T., Trubetskoy V., Torchilin V., Langer R. Biodegradable long-circulating polymeric nanospheres. Science 1994; 263: 1600–1603
  • Gref R., Minamitake Y., Peraccia M. T., Domb A., Trubetskoy V., Torchilin V., Langer R. Poly (ethylene glycol)-coated nanospheres: potential carriers for intravenous drug administration. Protein Delivery Physical Systems, L. M. Sanders, R. W. Hendren. Plenum, New York 1997; 167–197
  • Guiziou B., Armstrong D. J., Elliott P. N. C., Ford J. L., Rostron C. Investigation of in-vitro release characteristics of NSAIDS-loaded polylactic acid microspheres. Journal of Microencapsulation 1996; 13: 701–708
  • Hildgen P., Panoyan A. Stealth behaviour of (PLA-PEG-PLA) multiblock nanospheres after IV injection. Proceedings of 13th International Symposium on Microencapsulation. 2001; 59
  • Hutchinson F. G., Furr B. J. A. Biodegradable polymer for the sustained release of polypeptides. Journal of Controlled Release 1990; 13: 279–294
  • Ike O., Shimizu Y., Wada R., Hyon S. H., Ikada Y. Controlled cisplatin delivery system using poly (D, L-lactic acid). Biomaterials 1992; 13: 230–234
  • Kim S. Y., Shin I. G., Lee Y. M. Preparation and characterization of biodegradable nanospheres composed of methoxy poly (ethylene glycol) and dl-lactide block copolymer as novel drug carriers. Journal of Controlled Release 1998; 56: 197–208
  • Kreuter J. Nanoparticles and microparticles for drug and vaccine delivery. Journal of Anatomy 1996; 189: 503–505
  • Lacasse F. X., Hildgen P., Perodin J., Escher E., Phillips N. C., McMullen J. N. Improved activity of a new angiotensin receptor antagonist by an injectable spray-dried polymer microsphere preparation. Pharmaceutical Research 1997; 14: 887–891
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983; 65: 55–63
  • Muller R. H. Colloidal Carriers for Controlled Drug Delivery and Targeting: Modification, Characterization, and In Vivo Distribution. CRC Press, Boca Raton 1991; 45–46
  • Peracchia M. T., Gref R., Minamitake Y., Domb A., Lotan N., Langer R. PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: investigation of their drug encapsulation and release characteristics. Journal of Controlled Release 1997; 46: 223–231
  • Prior S., Gamazo C., Irache J. M., Merkle H. P., Gander B. Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections. International Journal of Pharmaceutics 2000; 196: 115–125
  • Quesnel R., Hildgen P. Synthesis and characterization of alternate (PLA-PEG-PLA)m multiblock copolymers. Proceedings of ADRITEL/APGI/APV 2002; vol. 4: 619–620
  • Ramchandani M., Robinson D. In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants. Journal Controlled Release 1998; 54: 167–175
  • Soppimath K. S., Aminabhavi T. M., Kulkarni A. R., Rudzinski W. E. Biodegradable polymeric nanospheres as drug delivery devices. Journal of Controlled Release 2001; 70: 1–20
  • Tokuda K., Natsugoe S., Shimada M., Kumanohoso T., Baba M., Takao S., Nakamura K., Yamada K., Yoshizawa H., Hatate Y., Aikou T. Design and testing of a new cisplatin form using a base material by combining poly-D, L-lactic acid and polyethylene glycol acid against peritoneal metastasis. International Journal of Cancer 1998; 76: 709–712
  • Von Burekersroda F., Gref R., Göpeerich A. Erosion of biodegradable block copolymers made of poly (D, L-lactic acid) and poly (ethylene glycol). Biomaterials 1997; 18: 1599–1607
  • Youxin L., Volland C., Kissel T. In-vitro degradation and bovine serum albumin release of the ABA triblock copolymers consisting of poly (L(+) lactic acid), or poly(L(+) lactic acid-co-glycolic acid) A-blocks attached to central polyoxyethylene B-blocks. Journal of Controlled Release 1994; 32: 121–128
  • Zange R., Li Y., Kissel T. Biocompatibility testing of ABA triblock copolymers consisting of poly (L-lactic-co-glycolic acid) A blocks attached to a central poly (ethylene oxide) B block under in vitro conditions using different L929 mouse fibroblasts cell culture models. Journal of Controlled Release 1998; 56: 249–258
  • Zhu K. J., Xiangzhou L., Shilin Y. Preparation, characterization, and properties of polylactide (PLA)-poly (ethylene glycol) (PEG) copolymers: a potential drug carrier. Journal of Application of Polymeric Science 1990; 39: 1–9

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