92
Views
7
CrossRef citations to date
0
Altmetric
Original

Preparation and characterization of Vitamin-12 loaded biodegradable pH-sensitive microgels

, , , , , , , & show all
Pages 642-648 | Received 05 Nov 2008, Accepted 09 Nov 2008, Published online: 05 Nov 2009

References

  • Bernkop-Schnurch A, Walker G. Multifunctional matrices for oral peptide delivery. Crit Rev Ther Drug Carrier Syst 2001; 18: 459–502
  • Chang HY, Sei H. Effects of intravenously administered vitamin B12 on sleep in the rat. Physiol Behav 1995; 57: 1019–1024
  • Chao GT, Deng HX, Huang Q, Jia WJ, Huang WX, Gu YC, et al. Preparation and characterization of pH sensitive semi-interpenetrating network hydrogel based on methacrylic acid, bovine serum albumin (BSA), and PEG. J Polym Res 2006; 13: 349–355
  • Chao GT, Huang MJ, Kan B, Gu YC, Gong CY, Yang JL, et al. Synthesis, characterization, and hydrolytic degradation behavior of a novel biodegradable pH-sensitive hydrogel based on PCL, methacrylic acid, and poly(ethylene glycol). J Biomed Mater Res A 2008; 85: 36–46
  • Chen X, Qian ZY, Gou ML, Chao GT, Zhang YD, Gu YC, et al. Acute oral toxicity evaluation of biodegradable and pH-sensitive hydrogel based on polycaprolactone, poly(ethylene glycol) and methylacrylic acid (MAA). J Biomed Mater Res A 2008; 84: 589–597
  • Drummond RK, Klier J, Alameda JA, Peppas NA. Preparation of poly(methacrylic acid-g-ethylene oxide) microspheres. Macromolecules 1989; 22: 3816–3818
  • Ha JC, Kim SY, Lee YM. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (pluronic)/poly(ε-caprolactone) (PCL) amphiphilic block copolymeric nanospheres. I. Preparation and characterization. J Contr Rel 1999; 62: 381–392
  • Kaggwa GB, Carey MJ. A new family of water-swellable microgel particles. J Colloid Interface Sci 2003; 257: 392–397
  • Krishna Rao KSV, Vijaya Kumar Naidu B. Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil. Carbohyd Polym 2006; 66: 333–344
  • Liu CB, Gong CY, Pan YF, Zhang YD, Wang JW, Wang YS, et al. Synthesis and characterization of a thermosensitive hydrogel based on biodegradable amphiphilic PCL-pluronic (L35)-PCL block copolymers. Colloid Surf A Phys Chem Asp 2007; 302: 430–438
  • Nguyen KT, West JL. Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 2002; 23: 4307–4314
  • Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Del Rev 2001; 53: 321–339
  • Torres-Lugo M, Garcia M, Record R, Peppas NA. Physicochemical behavior and cytotoxic effects of poly(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins. J Contr Rel 2002; 80: 197–205
  • Torres-Lugo M, Peppas NA. Molecular dosing and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin. Macromolecules 1999; 32: 6646–6651
  • Zhang Y, Zhu W. A novel microgel and associated post-fabrication encapsulation technique of proteins. J Contr Rel 2005; 105: 260–268

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.