196
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Preparation and evaluation of thiomer nanoparticles via high pressure homogenization

, , , &
Pages 487-495 | Received 12 Nov 2009, Accepted 30 Nov 2009, Published online: 31 Mar 2010

References

  • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Contr Rel 2004; 100: 5–28
  • Ameller T, Marsaud V, Legrand P, Gref R, Barratt G, Renoir JM. Polyester-poly(ethylene glycol) nanoparticles loaded with the pure antiestrogen RU 58668: Physicochemical and opsonisation properties. Pharm Res 2003; 20: 1063–1070
  • Bernkop-Schnürch A. Thiomers: A new generation of mucoadhesive polymers. Adv Drug Del Rev 2005; 57: 1569–1582
  • Bernkop-Schnürch A, Guggi D, Pinter Y. Thiolated chitosans: Development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J Contr Rel 2004; 94: 177–186
  • Bernkop-Schnürch A, Heinrich A, Greimel A. Development of a novel method for the preparation of submicron particles based on thiolated chitosan. Eur J Pharm Biopharm 2006a; 63: 166–172
  • Bernkop-Schnürch A, Schwarz V, Steininger S. Polymers with thiol groups: A new generation of mucoadhesive polymers?. Pharm Res 1999; 16: 876–881
  • Bernkop-Schnürch A, Weithaler A, Albrecht K, Greimel A. Thiomers: Preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system. Int J Pharm 2006b; 317: 76–81
  • Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: Effect of particle size. Pharm Res 1996; 13: 1838–1845
  • Deutel B, Greindl M, Thaurer M, Bernkop-Schnürch A. Novel insulin thiomer nanoparticles: in vivo evaluation of an oral drug delivery system. Biomacromolecules 2008; 9: 278–285
  • Greindl M, Bernkop-Schnürch A. Development of a novel method for the preparation of thiolated polyacrylic acid nanoparticles. Pharm Res 2006; 23: 2183–2189
  • Habeeb AF. A sensitive method for localization of disulfide containing peptides in column effluents. Anal Biochem 1973; 56: 60–65
  • He P, David SS, Illum L. Chitosan microspheres prepared by spray drying. Int J Pharm 1999; 187: 53–65
  • Hoyer H, Föger F, Kafedjiiski K, Loretz B, Bernkop-Schnürch A. Design and evaluation of a new gastrointestinal mucoadhesive patch system containing chitosan-glutathione. Drug Dev Ind Pharm 2007; 33: 1289–1296
  • Hoyer H, Schlocker W, Kafedjiiski K, Bernkop-Schnürch A. Preparation and evaluation of microparticles from thiolated polymers via air jet milling. Eur J Pharm Biopharm 2008; 69: 476–485
  • Kafedjiiski K, Föger F, Werle M, Bernkop-Schnürch A. Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate. Pharm Res 2005a; 22: 1480–1488
  • Kafedjiiski K, Jetti RK, Föger F, Hoyer H, Werle M, Hoffer M, Bernkop-Schnürch A. Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery. Int J Pharm 2007; 343: 48–58
  • Kafedjiiski K, Krauland AH, Hoffer MH, Bernkop-Schnürch A. Synthesis and in vitro evaluation of a novel thiolated chitosan. Biomaterials 2005b; 26: 819–826
  • Kafedjiiski K, Werle M, Föger F, Bernkop-Schnürch A. Synthesis and in vitro characterization of a novel poly(acrylic acid)-glutathione conjugate. J Drug Del Sci Tech 2005c; 15: 411–417
  • Kafedjiiski K, Werle M, Hoffer M, Bernkop-Schnürch A. Improved synthesis and in vitro characterization of a chitosan-thioethylamidine conjugate. Biomaterials 2006; 27: 127–135
  • Kast CE, Guggi D, Langoth N, Bernkop-Schnürch A. Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil. Pharm Res 2003; 20: 931–936
  • Kirby BJ, Hasselbrink EF. Zeta potential of microfluidic substrates: 2. Data for polymers. Electrophoresis 2004; 25: 203–213
  • Kriwet B, Walter E, Kissel T. Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates. J Contr Rel 1998; 56: 149–158
  • Lamprecht A, Ubrich N, Hombeiro P, Lehr CM, Hofmann M, Maincent P. Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification. Int J Pharm 1999; 184: 97–105
  • Lamprecht A, Ubrich N, Yamamoto H, Schäfer U, Takeuchi H, Maincent P, Kawashima Y, Lehr CM. Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. J Pharmacol Exp Ther 2001; 299: 775–781
  • Lee WK, Park JY, Yang EH, Suh H, Kim SH, Chung DS, Choi K, Yang CW, Park JS. Investigations of the factors influencing the release rates of cyclosporine A-loaded micro and nanoparticles prepared by high pressure homogenizer. J Contr Rel 2002; 84: 115–123
  • Lige B, Ma S, van Huystee RB. The effects of the site-directed removal of N-glycosylation from cationic peanut peroxidase on its function. Arch Biochem Biophys 2001; 386: 17–24
  • Machado MF, Saraiva JM. Thermal stability and activity regain of horseradish peroxidase in aqueous mixtures of imidazolium-based ionic liquids. Biotechnol Lett 2005; 27: 1233–1239
  • Mayer J, 2004. In column EFTEM Technology with Corrected Omega Filter. Carl Zeiss SMT Nano Technology Systems Division, Carl Zeiss NTS GMBH (Oberkochen, Germany).
  • Monharaj VJ, Chen Y. Nanoparticles—a review. Trop J Pharm Res 2006; 5: 561–573
  • Nahar M, Dutta T, Murugesan S, Asthana A, Mishra D, Rajkumar V, Tare M, Saraf S, Jain NK. Functional polymeric nanoparticles: An efficient and promising tool for active delivery of bioactives. Crit Rev Therap Drug Carr Sys 2006; 23: 259–318
  • Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55: 329–347
  • Sahoo SK, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly(D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J Contr Rel 2002; 82: 105–114
  • Schlocker W, Gschließer S, Bernkop-Schnürch A. Evaluation of the potential of air jet milling of solid protein-poly(acrylate) complexes for microparticle preparation. Eur J Pharm Biopharm 2006; 62: 260–266
  • Thaler SC, Bernkop-Schnürch A. Polycarbophil-cysteine conjugates as platforms for oral polypeptide delivery systems. J Pharm Sci 1999; 89: 901–909
  • Vinagradov SV, Bronich TK, Kabanov AV. Nanosized cationic hydrogels for drug delivery: Preparation, properties and interactions with cells. Adv Drug Del Rev 2002; 54(1)223–233
  • Werle M. Natural and synthetic polymers as inhibitors of drug efflux pumps. Pharm Res 2008; 25: 500–511

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.