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Research Article

Ivermectin-loaded microparticles for parenteral sustained release: in vitro characterization and effect of some formulation variables

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Pages 609-617 | Received 23 Feb 2010, Accepted 24 May 2010, Published online: 10 Aug 2010

References

  • Bassissi F, Lespine A, Alvinerie M. Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration. Parasitol Res 2006; 98: 244–9
  • Benoit JP, Courteille F, Thies C. A physicochemical study of the morphology of progesterone-loaded poly (D,L-lactide) microspheres. Int J Pharm 1986; 29: 95–102
  • Bodmeier R, Chen H. Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen. J Control Release 1989; 10: 167–75
  • Bodmeier R, McGinity JW. Solvent selection in the preparation of poly(DL-Lactide) microspheres prepared by the solvent evaporation method. Int J Pharm 1988; 43: 179–86
  • Brannon-Peppas L. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int J Pharm 1995; 116: 1–9
  • Chhabra S, Sachdeva V, Singh S. Influence of end groups on in vitro release and biological activity of lysozyme from a phase-sensitive smart polymer-based in situ gel forming controlled release drug delivery system. Int J Pharm 2007; 342: 72–7
  • Clark SL, Crowley AJ, Schmidt PG, Donoghue AR, Piche CA. Long-term delivery of ivermectin by use of poly(D,L-lactic-co-glycolic)acid microparticles in dogs. Am J Vet Res 2004; 65: 752–7
  • Dunne M, Corrigan I, Ramtoola Z. Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. Biomaterials 2000; 21: 1659–68
  • Frank A, Rath SK, Venkatraman SS. Controlled release from bioerodible polymers: effect of drug type and polymer composition. J Control Release 2005; 102: 333–44
  • Freiberg S, Zhu XX. Polymer microspheres for controlled drug release. Int J Pharm 2004; 282: 1–18
  • Gokbulut C, Karademir U, Boyacioglu M, McKellar QA. Comparative plasma dispositions of ivermectin and doramectin following subcutaneous and oral administration in dogs. Vet Parasitol 2006; 135: 347–54
  • Gonzalez Canga A, Sahagun Prieto AM, Jose Diez Liebana M, Martinez NF, Vega MS, Vieitez JJ. The pharmacokinetics and metabolism of ivermectin in domestic animal species. Vet J 2009; 179: 25–37
  • Hasan AS, Socha M, Lamprecht A, Ghazouani FE, Sapin A, Hoffman M, Maincent P, Ubrich N. Effect of the microencapsulation of nanoparticles on the reduction of burst release. Int J Pharm 2007; 344: 53–61
  • Hausberger AG, DeLuca PP. Characterization of biodegradable poly(D,L-lactide-co-glycolide) polymers and microspheres. J Pharm Biomed Anal 1995; 13: 747–60
  • Hennessy DR. Modifying the formulation or delivery mechanism to increase the activity of anthelmintic compounds. Vet Parasitol 1997; 72: 367–82; discussion 382–90
  • Herrmann J, Bodmeier R. The effect of particle microstructure on the somatostatin release from poly(lactide) microspheres prepared by a W/O/W solvent evaporation method. J Control Release 1995; 36: 63–71
  • Jaraswekin S, Prakongpan S, Bodmeier R. Effect of poly(lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles. J Microencapsul 2007; 24: 117–28
  • Kim JE, Kim SR, Lee SH, Lee CH, Kim DD. The effect of pore formers on the controlled release of cefadroxil from a polyurethane matrix. Int J Pharm 2000; 201: 29–36
  • Klose D, Siepmann F, Elkharraz K, Krenzlin S, Siepmann J. How porosity and size affect the drug release mechanisms from PLGA-based microparticles. Int J Pharm 2006; 314: 198–206
  • Klose D, Siepmann F, Elkharraz K, Siepmann J. PLGA-based drug delivery systems: importance of the type of drug and device geometry. Int J Pharm 2008; 354: 95–103
  • Kubin A, Loew HG, Burner U, Jessner G, Kolbabek H, Wierrani F. How to make hypericin water-soluble. Pharmazie 2008; 63: 263–9
  • Liu J, Chang Z, Sun X, Shen S, Lei C, Liu H. Impurity effects on the crystallization of avermectin B1a. J. Crystal Growth 2006; 291: 448–54
  • Loffler D, Ternes TA. Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography-tandem mass spectrometry. J Chromatogr A 2003; 1021: 133–44
  • Luan X, Bodmeier R. Modification of the tri-phasic drug release pattern of leuprolide acetate-loaded poly(lactide-co-glycolide) microparticles. Eur J Pharm Biopharm 2006; 63: 205–14
  • McGinity JW, O'Donnell PB. Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliv Rev 1997; 28: 25–42
  • Miller JA, Davey RB, Oehler DD, Pound JM, George JE, Ahrens EH. Control of Boophilus annulatus (Acari: Ixodidae) on cattle using injectable microspheres containing ivermectin. J Econ Entomol 1999; 92: 1142–6
  • Miller JA, Oehler DD, Pound JM. Delivery of ivermectin by injectable microspheres. J Econ Entomol 1998; 91: 655–9
  • Mundargi RC, Babu VR, Rangaswamy V, Patel P, Aminabhavi TM. Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J Control Release 2008; 125: 193–209
  • Omura S. Ivermectin: 25 years and still going strong. Int J Antimicrob Agents 2008; 31: 91–8
  • Palmieri GF, Cantalamessa F, Di Martino P, Nasuti C, Martelli S. Lonidamine solid dispersions: In vitro and in vivo evaluation. Drug Devel Indus Pharm 2002; 28: 1241–50
  • Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V. Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles. J Pharm Sci 2004; 93: 1804–14
  • Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997; 28: 5–24
  • Siepmann J, Elkharraz K, Siepmann F, Klose D. How autocatalysis accelerates drug release from PLGA-based microparticles: A quantitative treatment. Biomacromolecules 2005; 6: 2312–19
  • Sun Y, Scruggs DW, Peng Y, Johnson JR, Shukla AJ. Issues and challenges in developing long-acting veterinary antibiotic formulations. Adv Drug Deliv Rev 2004; 56: 1481–96
  • Takano R, Sugano K, Higashida A, Hayashi Y, Machida M, Aso Y, Yamashita S. Oral absorption of poorly water-soluble drugs: Computer simulation of fraction absorbed in humans from a miniscale dissolution test. Pharm Res 2006; 23: 1144–56
  • Tracy MA, Ward KL, Firouzabadian L, Wang Y, Dong N, Qian R, Zhang Y. Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials 1999; 20: 1057–62
  • Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chem Rev 1999; 99: 3181–98
  • Winzenburg G, Schmidt C, Fuchs S, Kissel T. Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems. Adv Drug Deliv Rev 2004; 56: 1453–66
  • Wischke C, Schwendeman SP. Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. Int J Pharm 2008; 364: 298–327
  • Yu L. Amorphous pharmaceutical solids: preparation, characterization and stabilization. Adv Drug Deliv Rev 2001; 48: 27–42

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