Insulin-loaded PLGA microparticles: flow focusing versus double emulsion/solvent evaporation

References

• Arias JL, Gallardo V, Ruiz MA, Delgado AV. Ftorafur loading and controlled release from poly(ethyl-2-cyanoacrylate) and poly(butylcyanoacrylate) nanospheres. Int J Pharm 2007; 337: 282–90
   PubMed Web of Science ®Google Scholar
• Arias JL, Gómez-Gallo A, Delgado AV, Gallardo V. Study of the stability of Kollidon® SR suspensions for pharmaceutical applications. Colloids Surf A 2009; 338: 107–13
   Google Scholar
• Arias JL, López-Viota M, Gallardo V, Ruiz MA. Chitosan nanoparticles as a new delivery system for the chemotherapy agent tegafur. Drug Dev Ind Pharm 2010; 36: 744–50
   PubMed Web of Science ®Google Scholar
• Arias JL, Ruiz MA, López-Viota M, Delgado AV. Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: A comparative study. Colloids Surf B 2008; 62: 64–70
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A. The use of inhibitory agents to overcome the enzymatic barrier to perorally administrated therapeutic peptides and proteins. J Control Release 1998; 52: 1–16
   PubMed Web of Science ®Google Scholar
• Bhardwaj V, Hariharan S, Bala I, Lamprecht A, Kumar N, Panchagnula R, Kumar N. Pharmaceutical aspects of polymeric nanoparticles for oral delivery. J Biomed Nanotechnol 2005; 1: 235–58
   Web of Science ®Google Scholar
• Bloemendal M, Jiskoot W. Circular dichroism spectroscopy. Methods for structural analysis of protein pharmaceuticals, W Jiskoot, D Crommelin. AAPS Press, Arlington 2005; 83–130
   Google Scholar
• Corrigan OI, Li X. Quantifying drug release from PLGA nanoparticulates. Eur J Pharm Sci 2009; 37: 477–85
   PubMed Web of Science ®Google Scholar
• Cui F, Shi K, Zhang L, Tao A, Kawashima Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. J Control Release 2006; 114: 242–50
   PubMed Web of Science ®Google Scholar
• Das T, Becker T, Nair BN. Measurements on hydrophobic and hydrophilic surfaces using a porous gamma alumina nanoparticle aggregate mounted on atomic force microscopy cantilevers. Thin Solid Films 2010; 518: 2769–74
   Web of Science ®Google Scholar
• Díez S, Tros de Ilarduya C. Versatility of biodegradable poly(D,L-lactic-co-glycolic acid) microspheres for plasmid DNA delivery. Eur J Pharm Biopharm 2006; 63: 188–97
   PubMed Web of Science ®Google Scholar
• Dillen K, Vandervoort J, Van den Mooter G, Verheyden L, Ludwig A. Factorial design, physicochemical characterisation and activity of ciprofloxacin-PLGA nanoparticles. Int J Pharm 2004; 275: 171–87
   PubMed Web of Science ®Google Scholar
• Emami J, Hamishehkar H, Najafabadi AR, Gilani K, Minaiyan M, Mahdavi H, Nokhodchi A. A novel approach to prepare insulin- loaded poly (lactic-co-glycolic acid) microcapsules and the protein stability study. J Pharm Sci 2009; 98: 1712–31
   PubMed Web of Science ®Google Scholar
• Fan YF, Wang YN, Fan YG, Ma JB. Preparation of insulin nanoparticles and their encapsulation with biodegradable polyelectrolytes via the layer-by-layer adsorption. Int J Pharm 2006; 324: 158–67
   PubMed Web of Science ®Google Scholar
• Gañán-Calvo AM. Generation of steady liquid microthreads and micron-sized monodisperse sprays in gas streams. Phys Rev Lett 1998; 80: 285–8
   Web of Science ®Google Scholar
• Gaumet M, Gurny R, Delie F. Interaction of biodegradable nanoparticles with intestinal cells: The effect of surface hydrophilicity. Int J Pharm 2010; 390: 45–52
   PubMedGoogle Scholar
• Gök E, Olgaz S. Binding of fluorescein isothiocyanate to insulin: A fluorimetric labeling study. J Fluoresc 2004; 14: 203–6
   PubMed Web of Science ®Google Scholar
• Gómez-Gaete C, Tsapis N, Besnard M, Bochot A, Fattal E. Encapsulation of dexamethasone into biodegradable polymeric nanoparticles. Int J Pharm 2007; 331: 153–9
   PubMed Web of Science ®Google Scholar
• Hamishehkar H, Emami J, Najafabadi AR, Gilani K, Minaiyan M, Mahdavi H, Nokhodchi A. The effect of formulation variables on the characteristics of insulin-loaded poly(lactic-co-glycolic acid) microspheres prepared by a single phase oil in oil solvent evaporation method. Colloids Surf B 2009; 74: 340–9
   PubMed Web of Science ®Google Scholar
• Hillery AM, Florence AT. The effect of adsorbed poloxamer 188 and 407 surfactants on the intestinal uptake of 60-nm polystyrene particles after oral administration in the rat. Int J Pharm 1996; 132: 123–30
   Web of Science ®Google Scholar
• Holgado MA, Arias JL, Cózar MJ, Álvarez-Fuentes J, Gañán-Calvo AM, Fernández-Arévalo M. Synthesis of lidocaine-loaded PLGA microparticles by flow focusing. Effects on drug loading and release properties. Int J Pharm 2008; 358: 27–35
   PubMed Web of Science ®Google Scholar
• Holgado MA, Cózar-Bernal MJ, Salas S, Arias JL, Álvarez-Fuentes J, Fernández-Arévalo M. Protein-loaded PLGA microparticles engineered by flow focusing: Physicochemical characterization and protein detection by reversed-phase HPLC. Int J Pharm 2009; 380: 147–54
   PubMed Web of Science ®Google Scholar
• Ibrahim MA, Ismail A, Fetouh MI, Göpferich A. Stability of insulin during the erosion of poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres. J Control Release 2005; 106: 241–52
   PubMed Web of Science ®Google Scholar
• Johnson KL, Kendall K, Roberts AD. Surface energy and the contact of elastic solids. Proc R Soc Lond A 1971; 324: 301–13
   Web of Science ®Google Scholar
• Kawashima Y, Yamamoto H, Takeuchi H, Fujioka S, Hino T. Pulmonary delivery of insulin with nebulized dl-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J Control Release 1999; 62: 279–87
   PubMed Web of Science ®Google Scholar
• Kumar N, Ravikumar MNV, Domb AJ. Biodegradable block copolymers. Adv Drug Deliv Rev 2001; 53: 23–44
   PubMed Web of Science ®Google Scholar
• Kumar PS, Saini TR, Chandrasekar D, Yellepeddi VK, Ramakrishna S, Diwan P. Novel approach for delivery of insulin loaded poly(lactide-co-glycolide) nanoparticles using a combination of stabilizers. Drug Deliv 2007; 14: 517–23
   PubMed Web of Science ®Google Scholar
• Leo E, Pecquet S, Rojas J, Couvreur P, Fattal E. Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. J Microencapsul 1998; 15: 421–30
   PubMed Web of Science ®Google Scholar
• Liu R, Huang SS, Wan YH, Ma GH, Su ZG. Preparation of insulin-loaded PLA/PLGA microcapsules by a novel membrane emulsification method and its release in vitro. Colloids Surf B 2006; 51: 30–8
   PubMed Web of Science ®Google Scholar
• Luan X, Bodmeier R. Influence of the poly(lactide-co-glycolide) type on the leuprolide release from in situ forming microparticle systems. J Control Release 2006; 110: 266–72
   PubMed Web of Science ®Google Scholar
• Luque A, Perdigones F, Estevé J, Montserrat J, Gañán-Calvo AM, Quero JM. Reduction of dropet-size dispersion in parallel flow-focusing microdevices using a passive method. J Micromech Microeng 2009; 19: 45029–36
   Web of Science ®Google Scholar
• Martín-Banderas L, Flores-Mosquera M, Riesco-Chueca P, Rodriguez-Gil A, Cebolla A, Chávez S, Gañán-Calvo AM. Flow focusing: A versatile technology to produce size-controlled and specific-morphology microparticles. Small 2005; 1: 688–92
   PubMed Web of Science ®Google Scholar
• Martín-Banderas L, Rodriguez-Gil A, Cebolla A, Chávez S, Berdún-Álvarez T, Fernández JM, Flores-Mosquera M, Gañán-Calvo AM. Towards a high throughput production of uniform encoded microparticles. Adv Mater 2006; 18: 559–64
   Web of Science ®Google Scholar
• Matsuura J, Powers ME, Manning MC, Shefter E. Structure and stability of insulin dissolved in 1-octanol. J Am Chem Soc 1993; 115: 1261–4
   Web of Science ®Google Scholar
• Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MNV. Estradiol loaded PLGA nanoparticles for oral administration: Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release 2007; 119: 77–85
   PubMed Web of Science ®Google Scholar
• Mundargi RC, Ramesh Babu V, Rangaswamy V, Patel P, Aminabhavi TM. Nano/micro technologies for delivering macromolecular therapeutics using poly(d,l-lactide-co-glycolide) and its derivatives. J Control Release 2008; 125: 193–209
   PubMed Web of Science ®Google Scholar
• Musumeci T, Ventura CA, Giannone I, Ruozi B, Montenegro L, Pignatello R, Puglisi G. PLA/PLGA nanoparticles for sustained release of docetaxel. Int J Pharm 2006; 325: 172–9
   PubMed Web of Science ®Google Scholar
• Myers SR, Yakubu-Madus FE, Johnson WT, Baker JE, Cusick TS, Williams VK, Tinsley FC, Kriauciunas A, Manetta J, Chen VJ. Acylation of human insulin with palmitic acid extends the time action of human insulin in diabetic dogs. Diabetes 1997; 46: 637–42
   PubMed Web of Science ®Google Scholar
• Nicoli S, Santi P, Couvreur P, Couarraze G, Colombo P, Fattal E. Design of triptorelin loaded nanospheres for transdermal iontophoretic administration. Int J Pharm 2001; 214: 31–5
   PubMed Web of Science ®Google Scholar
• Norris DA, Puri N, Sinko PJ. The effect of physical barriers and properties on the oral absorption of particulates. Adv Drug Deliv Rev 1998; 34: 135–54
   PubMed Web of Science ®Google Scholar
• Nyambura BK, Kellaway IW, Taylor KMG. Insulin nanoparticles: Stability and aerosolization from pressurized metered dose inhalers. Int J Pharm 2009; 375: 114–22
   PubMed Web of Science ®Google Scholar
• O’Brien RW, White LR. Electrophoretic mobility of a spherical colloidal particle. J Chem Soc Faraday Trans 1978; 2: 1607–26
   Google Scholar
• Okassa LN, Marchais H, Douziech-Eyrolles L, Hervé K, Cohen-Jonathan S, Munnier E, Soucé M, Linassier C, Dubois P, Chourpa I. Optimization of iron oxide nanoparticles encapsulation within poly(D,L-lactide-co-glycolide) sub-micron particles. Eur J Pharm Biopharm 2007; 67: 31–8
   PubMed Web of Science ®Google Scholar
• Pinto-Reis C, Ribeiro AJ, Houng S, Veiga F, Neufeld RJ. Nanoparticulate delivery system for insulin: Design, characterization and in vitro/in vivo bioactivity. Eur J Pharm Sci 2007; 30: 392–7
   PubMed Web of Science ®Google Scholar
• Sahana DK, Mittal G, Bhardwaj V, Ravikumar MNV. PLGA nanoparticles for oral delivery of hydrophobic drugs: Influence of organic solvent on nanoparticle formation and release behavior in vitro and in vivo using estradiol as a model drug. J Pharm Sci 2008; 97: 1530–42
   PubMed Web of Science ®Google Scholar
• Sahoo SK, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J Control Release 2002; 82: 105–14
   PubMed Web of Science ®Google Scholar
• Sajeesh S, Sharma CP. Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int J Pharm 2006; 325: 147–54
   PubMed Web of Science ®Google Scholar
• Santander-Ortega MJ, Bastos-González D, Ortega-Vinuesa JL, Alonso MJ. Insulin-loaded PLGA nanoparticles for oral administration: An in vitro physico-chemical characterization. J Biomed Nanotechnol 2009; 5: 45–53
   PubMed Web of Science ®Google Scholar
• Shelma R, Paul W, Sharma CP. Development and characterization of self-aggregated nanoparticles from anacardoylated chitosan as a carrier for insulin. Caborhydr Polym 2010; 80: 285–90
   Web of Science ®Google Scholar
• Sonaje K, Chen YJ, Chen HL, Wey SP, Juang JH, Nguyen HN, Hsu CW, Lin KJ, Sung HW. Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010; 31: 3384–94
   PubMed Web of Science ®Google Scholar
• Tatford OC, Gomme PT, Bertolini J. Analytical techniques for the evaluation of liquid protein therapeutics. Biotechnol Appl Biochem 2004; 40: 67–81
   PubMed Web of Science ®Google Scholar
• Teixeira M, Alonso MJ, Pinto MMM, Barbosa CM. Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone. Eur J Pharm Biopharm 2005; 59: 491–500
   PubMed Web of Science ®Google Scholar
• Vadillo-Rodríguez V, Busscher HJ, Van der Mei HC, Vries J, Norde W. Role of lactobacillus cell surface hydrophobicity as probed by AFM in adhesion to surfaces at low and high ionic strength. Colloids Surf B 2005; 41: 33–41
   PubMed Web of Science ®Google Scholar
• Yong Z, Yingjie D, Xueli W, Jinghua X, Zhengqiang L. Conformational and bioactivity analysis of insulin: Freeze-drying TBA/water co-solvent system in the presence of surfactant and sugar. Int J Pharm 2009; 371: 71–81
   PubMedGoogle Scholar
• Zhou XH, Po ALW. Peptide and protein drugs: I. Therapeutic applications, absorption and parenteral administration. Int J Pharm 1991a; 75: 97–115
   Web of Science ®Google Scholar
• Zhou XH, Po ALW. Peptide and protein drugs: II. Non-parenteral routes of delivery. Int J Pharm 1991b; 75: 117–30
   Web of Science ®Google Scholar