607
Views
34
CrossRef citations to date
0
Altmetric
Review Article

Nanoparticles and the skin – applications and limitations

Pages 709-716 | Received 11 Feb 2011, Accepted 13 Jun 2011, Published online: 18 Jul 2011

References

  • Auffan M, Rose J, Bottero J-Y, Lowry GV, Jolivet J-P, Wiesner MR. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 2009; 4: 634–41
  • Baroli B. Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality. J Pharm Sci 2010; 99: 21–50
  • Baroli B, Ennas MG, Loffredo F, Isola M, Pinna R, López-Quintela MA. Penetration of metallic nanoparticles in human full-thickness skin. J Invest Dermatol 2007; 127: 1701–12
  • Barry BW. Lipid-protein-partition theory of skin penetration enhancement. J Control Release 1991; 15: 237–48
  • Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. Human skin penetration of sunscreen nanoparticles: In-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol 2007; 20: 148–54
  • Degim IT, Burgess DJ, Papadimitrakopoulos F. Carbon nanotubes for transdermal drug delivery. J Microencapsul 2010; 27: 669–81
  • Filipe P, Silva JN, Silva R, Cirne de Castro JL, Marques Gomes M, Alves LC, Santus R, Pinheiro T. Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticle percutaneous absorption. Skin Pharmacol Physiol 2009; 22: 266–75
  • Filon FL, D’Agostin F, Crosera M, Adami G, Rosani R, Romano C, Bovenzi M, Maina G. In vitro percutaneous absorption of silver nanoparticles. G Ital Med Lav Ergon 2007; 29(Suppl. 3)451–2
  • Gamer AO, Leibold E, van Ravenzwaay B. The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol In Vitro 2006; 20: 301–7
  • Gontier E, Ynsa M-D, Bíró T, Hunyadi J, Kiss B, Gáspár K, Pinheiro T, Silva J-N, Filipe P, Stachura J, et al. Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study. Nanotoxicology 2008; 2(4)218–31
  • Graf C, Meinke M, Gao Q, Hadam S, Raabe J, Sterry W, Blume-Peytavi U, Lademann J, Rühl E, Vogt A. Qualitative detection of single submicron and nanoparticles in human skin by scanning transmission X-ray microscopy. J Biomed Opt 2009; 14: 021015
  • Gratieri T, Schaefer UF, Jing L, Gao M, Kostka K-H, Lopez RFV, Schneider M. Penetration of quantum dot particles through human skin. J Biomed Nanotechnol 2010; 6: 586–95
  • Gulson B, McCall M, Korsch M, Gomez L, Casey P, Oytam Y, Taylor A, McCulloch M, Trotter J, Kinsley L, et al. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicol Sci 2010; 118: 140–9
  • Hewitt JP. Titanium dioxide: A different kind of sunshield. Drug Cosmet Ind 1992; 151: 26–32
  • Illel B, Schaefer H, Wepierre J, Doucet O. Follicles play an important role in percutaneous absorption. J Pharm Sci 1991; 80: 424–7
  • Jeong SH, Kim JH, Yi SM, Lee JP, Kim JH, Sohn KH, Park KL, Kim M-K, Son SW. Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method. Biochem Biophys Res Commun 2010; 394: 612–15
  • Kato S, Aoshima H, Saitoh Y, Miwa N. Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. Basic Clin Pharmacol Toxicol 2009; 104: 483–7
  • Kreuter J. Nanoparticles – a historical perspective. Int J Pharm 2007; 331: 1–10
  • Lademann J, Richter H, Schaefer UF, Blume-Peytavi U, Teichmann A, Otberg N, Sterry W. Hair follicles – a long term reservoir for drug delivery. Skin Pharmacol Physiol 2006; 19: 232–6
  • Lademann J, Richter H, Teichmann A, Otberg N, Blume-Peytavi U, Luengo J, Weiss B, Schaefer UF, Lehr CM, Wepf R, et al. Nanoparticles-an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 2007; 66: 159–64
  • Larese FF, D’Agostin F, Crosera M, Adami G, Renzi N, Bovenzi M, Maina G. Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicology 2009; 255: 33–7
  • Luengo J, Weiss B, Schneider M, Ehlers A, Stracke F, König K, Kostka KH, Lehr CM, Schaefer UF. Influence of nanoencapsulation on human skin transport of flufenamic acid. Skin Pharmacol Physiol 2006; 19: 190–7
  • Mavon A, Miquel C, Lejeune O, Payre B, Moretto P. In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacol Physiol 2007; 20: 10–20
  • Mitchnick MA, Fairhurst D, Pinnell SR. Microfine zinc oxide (Z-Cote) as a photostable UVA/UVB sunblock agent. J Am Acad Dermatol 1999; 40: 85–90
  • Moser K, Kriwet K, Naik A, Kalia YN, Guy RH. Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm 2001; 52: 103–12
  • Neubert RH. Potentials of new nanocarriers for dermal and transdermal drug delivery. Eur J Pharm Biopharm 2011; 77: 1–2
  • Pflücker F, Wendel V, Hohenberg H, Gärtner E, Will T, Pfeiffer S, Wepf R, Gers-Barlag H. The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharmacol Appl Skin Physiol 2001; 14(Suppl 1)92–7
  • Rancan F, Papakostas D, Hadam S, Hackbarth S, Delair T, Primard C, Verrier B, Sterry W, Blume-Peytavi U, Vogt A. Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy. Pharm Res 2009; 26: 2027–36
  • Ravichandran S, Mortensen LJ, Delouise LA. Quantification of human skin barrier function and susceptibility to quantum dot penetration. Nanotoxicology, 2011;Epub ahead of print
  • Rouse JG, Yang J, Ryman-Rasmussen JP, Barron AR, Monteiro-Riviere NA. Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. Nano Lett 2007; 7: 155–60
  • Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol Sci 2006; 91: 159–65
  • Sadrieh N, Wokovich AM, Gopee NV, Zheng J, Haines D, Parmiter D, Siitonen PH, Cozart CR, Patri AK, McNeil SE, et al. Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles. Toxicol Sci 2010; 115(1)156–66
  • Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ Health Perspect 2010; 118(3)407–13
  • Santander-Ortega MJ, Stauner T, Loretz B, Ortega-Vinuesa JL, Bastos-González D, Wenz G, Schaefer UF, Lehr CM. Nanoparticles made from novel starch derivatives for transdermal drug delivery. J Control Release 2010; 141(1)85–92
  • Scheuplein RJ. Permeability of the skin. Physiol Rev 1971; 51: 702–47
  • Trommer H, Neubert RH. Overcoming the stratum corneum: The modulation of skin penetration. A review. Skin Pharmacol Physiol 2006; 19(2)106–21
  • Tsujimoto H, Hara K, Tsukada Y, Huang CC, Kawashima Y, Arakaki M, Okayasu H, Mimura H, Miwa N. Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects. Bioorg Med Chem Lett 2007; 17: 4771–7
  • van der Merwe D, Tawde S, Pickrell JA, Erickson LE. Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin. Cutan Ocul Toxicol 2009; 28: 78–82
  • Vettor M, Bourgeois S, Fessi H, Pelletier J, Perugini P, Pavanetto F, Bolzinger MA. Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: Estimation of the UV filter distribution and release behaviour in skin layers. J Microencapsulation 2010; 27: 253–62
  • Vogt A, Combadiere B, Hadam S, Stieler KM, Lademann J, Schaefer H, Autran B, Sterry W, Blume-Peytavi U. 40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin. J Invest Dermatol 2006; 126(6)1316–22
  • Walters KA, Roberts MS. The structure and function of skin. Dermatological and transdermal formulations, KA Walters. Marcel Dekker, New York 2002; 1–39
  • Wu X, Biatry B, Cazeneuve C, Guy RH. Drug delivery to the skin from sub-micron polymeric particle formulations: Influence of particle size and polymer hydrophobicity. Pharm Res 2009c; 26: 1995–2001
  • Wu X, Landfester K, Musyanovych A, Guy RH. Disposition of charged nanoparticles after their topical application to the skin. Skin Pharmacol Physiol 2010; 23: 117–23
  • Wu J, Liu W, Xue C, Zhou S, Lan F, Bi L, Xu H, Yang X, Zeng FD. Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 2009a; 191: 1–8
  • Wu X, Price GJ, Guy RH. Disposition of nanoparticles and an associated lipophilic permanent following topical application to the skin. Mol Pharm 2009b; 6: 1441–8
  • Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol 2010; 242: 29–37
  • Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA. Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol 2008; 228: 200–11
  • Zvyagin AV, Zhao X, Gierden A, Sanchez W, Ross JA, Roberts MS. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo. J Biomed Opt 2008; 13(6)064031

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.