Effect of PLGA hydrophilia on the drug release and the hypoglucemic activity of different insulin-loaded PLGA microspheres

References

• Banga AK. Therapeutic peptides and proteins. Formulation, processing, and delivery systems. CRC Press, Taylor & Francis Group, Boca Raton, FLUSA 2006
   Google Scholar
• de Rosa G, Iommelli R, La Rotonda MI, Miro A, Quaglia F. Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J Control Release 2000; 69: 283–95
   PubMed Web of Science ®Google Scholar
• Giteau A, Venier-Julienne MC, Aubert-Pouëssel A, Benoit JP. How to achieve sustained and complete protein release from PLGA-based microparticles?. Int J Pharm 2008; 350: 14–26
   PubMed Web of Science ®Google Scholar
• Hinds KD, Campbell KM, Holland KM, Lewis DH, Piché CA, Schmidt PG. PEGylated insulin in PLGA microparticles. In vivo and in vitro analysis. J Control Release 2005; 104: 447–60
   PubMed Web of Science ®Google Scholar
• Ibrahim MA, Ismail A, Fetouch MI, Göpferich A. Stability of insulin during the erosion of poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres. J Control Release 2005; 106: 241–52
   PubMed Web of Science ®Google Scholar
• Jiang G, Qiu W, DeLuca PP. Preparation and in vitro/in vivo evaluation of insulin loaded poly(acryloyl-hydroxyethyl starch)-PLGA composite microspheres. Pharm Res 2003; 20: 452–9
   PubMed Web of Science ®Google Scholar
• Jiang G, Woo BH, Kang F, Singh J, DeLuca PP. Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly(D,L-lactide-co-glycolide) microspheres. J Control Release 2002; 79: 137–45
   PubMed Web of Science ®Google Scholar
• Kang F, Singh J. Preparation, in vitro release, in vivo absorption and biocompatibility studies of insulin-loaded microspheres in rabbits. AAPS PharmSciTech 2005; 6: 487–94
   PubMed Web of Science ®Google Scholar
• Kim BS, Oh JM, Hyun H, Kim KS, Lee SH, Kim YH, Park K, Lee HB, Kim MS. Insulin loaded microcapsules for in vivo delivery. Mol Pharmaceutics 2009; 6: 353–65
   PubMed Web of Science ®Google Scholar
• Kwon YM, Baudys M, Knutson K, Kim SW. In situ study of insulin aggregation induced by water-organic solvent interface. Pharm Res 2001; 18: 1754–9
   PubMed Web of Science ®Google Scholar
• Manoharan C, Singh J. Insulin loaded PLGA microspheres: Effect of zinc salts on encapsulation, release and stability. J Pharm Sci 2009; 98: 529–42
   PubMed Web of Science ®Google Scholar
• Murty SB, Goodman J, Thanoo BC, DeLuca PP. Identification of chemically modified peptide from poly(D,L-lactide-co-glycolide) microspheres under in vitro release conditions. AAPS PharmSciTech 2003; 4: 392–405
   Google Scholar
• Na DH, Youn YS, Lee SD, Son M, Kim W, DeLuca PP, Lee KC. Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry. J Control Release 2003; 92: 291–9
   PubMed Web of Science ®Google Scholar
• Quaglia F, de Rosa G, Granata E, Ungaro F, Fattal E, La Rotonda MI. Feeding liquid, non-ionic surfactante and cyclodextrin affect the properties of insulin-loaded poly(lactide-co-glycolide) microspheres prepared by spray-drying. J Control Release 2003; 86: 267–78
   PubMed Web of Science ®Google Scholar
• Schoubben A, Blasi P, Giovagnoli S, Perioli L, Rossi C, Ricci M. Novel composite microparticles for protein stabilization and delivery. Eur J Pharm Sci 2009; 36: 226–34
   PubMed Web of Science ®Google Scholar
• Shao PG, Bailey LC. Porcine insulin biodegradable polyester microspheres: Stability and in vitro release characteristics. Pharm Dev Technol 2000; 5: 1–9
   PubMed Web of Science ®Google Scholar
• Shenoy DB, D'Souza RJ, Tiwari SB, Udupa N. Potential applications of polymeric microsphere suspension as subcutaneous depot for insulin. Drug Dev Ind Pharm, 2003;29:555–63.
   Google Scholar
• Takenaga M, Yamaguchi Y, Kitagawa A, Ogawa Y, Kawai S, Mizushima Y, Igarashi R. Optimum formulation for sustained-release insulin. Int J Pharm 2004; 271: 85–94
   PubMed Web of Science ®Google Scholar
• Takenaga M, Yamaguchi Y, Kitagawa A, Ogawa Y, Mizushima Y, Igarashi R. A novel insulin formulation can keep providing steady levels of insulin for much longer periods in-vivo. J Pharm Pharmacol 2002a; 54: 1189–94
   PubMed Web of Science ®Google Scholar
• Takenaga M, Yamaguchi Y, Kitagawa A, Ogawa Y, Mizushima Y, Igarashi R. A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release. J. Control. Release 2002b; 79: 81–91
   PubMed Web of Science ®Google Scholar
• Takenaga M, Yamaguchi Y, Ogawa Y, Kitagawa A, Kawai S, Mizushima Y, Igarashi R, Namae M, Komeda K. Administration of optimum sustained-insulin release PLGA microcapsules to spontaneous diabetes-prone BB/Wor//Tky rats. Drug Delivery 2006; 13: 149–57
   PubMed Web of Science ®Google Scholar
• Uchida T, Yagi A, Oda Y, Nakada Y, Goto S. Instability of bovine insulin in Poly(lactide-co-glycolide) (PLGA) microspheres. Chem Pharm Bull 1996; 44: 235–6
   PubMed Web of Science ®Google Scholar
• US Pharmacopoeia 29, 2005. US Pharmacopoeial Convention, Rockville, MD
   Google Scholar
• van der Walle CF, Sharma G, Ravi Kumar M. Current approaches to stabilising and analysing proteins during microencapsulation in PLGA. Expert Opin Drug Deliv 2009; 6: 177–86
   PubMed Web of Science ®Google Scholar
• van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res 2000; 17: 1159–67
   PubMed Web of Science ®Google Scholar
• Woo BH, Jiang G, Jo YW, DeLuca PP. Preparation and characterization of a composite PLGA and poly(acryloyl hydroxyethyl starch) microsphere system for protein delivery. Pharm Res 2001; 18: 1600–6
   PubMed Web of Science ®Google Scholar
• Yamaguchi Y, Takenaga M, Kitagawa A, Ogawa Y, Mizushima Y, Igarashi R. Insulin-loaded biodegradable PLGA microcapsules: Initial burst release controlled by hydrophilic additives. J Control Release 2002; 81: 235–49
   PubMed Web of Science ®Google Scholar
• Ye M, Kim S, Park K. Issues in long-term protein delivery using biodegradable microparticles. J Control Release 2010; 146: 241–60
   PubMed Web of Science ®Google Scholar
• Zhang JX, Chen D, Wang SJ, Zhu KJ. Optimizing double emulsion process to decrease the burst release of protein from biodegradable polymer microspheres. J Microencapsul 2005; 22: 413–22
   PubMed Web of Science ®Google Scholar