The novel oral imatinib microemulsions: physical properties, cytotoxicity activities and improved Caco-2 cell permeability

References

• Aserin A, Avrahami M, Garti N. Improved solubilization of celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution. J Colloid Interface Sci 2006; 299: 352–65
   Google Scholar
• Baspinar Y, 2010. Nano and microemulsions for topical application of poorly soluble immunosuppressives, PhD Thesis, Free University Berlin
   Google Scholar
• Bayrak Y, Iscan M. Phase inversion temperatures of triton X-100/1-butanol/hydrocarbon/water systems. J Surfact Deterg 2004; 7(4)363–66
   Google Scholar
• Cui J, Yu B, Zhao Y, Zhu W, Li H, Lou H, Zhai G. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm 2009; 371: 148–55
   PubMed Web of Science ®Google Scholar
• Czehowska A, Poplawski T, Drzewoski J, Blasiak J. Imatinib induces DNA damage in BCR/ABL expressing leukemic cells but not in normal lymphocytes. Chem Biol Interact 2005; 152: 139–50
   Google Scholar
• Demetri GD, Mehren MV, Blanke CD. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347: 472–80
   PubMed Web of Science ®Google Scholar
• Diculescu VC, Paquim AMC, Tugulea L, Vivan M, Brett AMO. Interaction of imatinib with liposomes: Voltammetric and AFM characterization. Bioelectrochemistry 2009; 74(2)278–88
   Google Scholar
• Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T. In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials 2003; 24(7)1121–31
   PubMed Web of Science ®Google Scholar
• Gamal ME. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants. Int J Pharm 2008; 355(1–2)285–92
   Google Scholar
• Ghosh PK, Majithiya RJ, Umrethia ML, Murthy RS. Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability. AAPS Pharm Sci Tech 2006; 7: 77
   PubMed Web of Science ®Google Scholar
• Gundogdu E, Alvarez Gonzalez I, Karasulu E. Improvement of effect of water in oil microemulsion as an oral delivery system for fexofenadine: In vitro and in vivo studies. Int J Nanomed 2011; 6: 1631–40
   PubMed Web of Science ®Google Scholar
• Hellinger E, Bakk LM, Pozca P, Tihanyi K, Vastag M. Drug penetration model of vinblastine-treated Caco-2 cultures. Eur J Pharm Sci 2010; 41: 96–106
   Google Scholar
• Karasulu E, Karaca B, Alparslan L, Karasulu HY. Places of microemulsion and emulsion in cancer therapy: In vitro and in vivo evaluation. Microemulsions. CRC Press, , M Fanun, 2008; 313–30
   Google Scholar
• Kawakami S, Opanasopit P, Yokoyama M, Chansri N, Yamamoto T, Okano T, Yamashita F, Hashida M. Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration. J Pharm Sci 2005; 94: 2606–15
   PubMed Web of Science ®Google Scholar
• Kogan A, Kesselman E, Danino D, Aserin A, Garti N. Viability and permeability across Caco-2 cells of carbamazepine solubilized in fully dilutable microemulsions. Colloids Surf B 2008; 66: 1–12
   PubMed Web of Science ®Google Scholar
• Konsoula R, Barile FA. Correlation of in vitro cytotoxicity with paracellular permeability in Caco-2 cells. Toxicology In Vitro 2005; 19(5): 675–84
   Google Scholar
• Lampe V, Milobedzka J. Studien uber curcumin. Ber Dtsch Chem Ges 1913; 46: 2235–40
   Google Scholar
• Lawrence MJ, Rees GD. Microemulsion based media as novel drug delivery systems. Adv Drug Deliv Rev 2000; 45: 89–121
   PubMed Web of Science ®Google Scholar
• Maestrelli F, Zerrouk N, Chemtob C, Mura P. Influence of chitosan and its glutamate and hydrochloride salts on naproxen dissolution rate and permeation across Caco-2 cells. Int J Pharm 2004; 271: 257–67
   PubMed Web of Science ®Google Scholar
• Mehren MV, Widmer N. Correlations between imatinib pharmacokinetics, pharmacodynamics, adherence, and clinical response in advanced metastatic gastrointestinal stromal tumor (GIST): An emerging role for drug blood level testing. Cancer Treat Rev 2011; 37(4)291–9
   Google Scholar
• Miura M, Takahashi N, Sawada K. Quantitative determination of imatinib in human plasma with high-performance liquid chromatography and ultraviolet detection. J Chromatogr Sci 2011; 49(5): 412–5
   Google Scholar
• Okur N, Apaydın S, Karabay Yavasoglu NU, Yavasoglu A, Karasulu HY. Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations. Int J Pharm 2011; 416(1)136–44
   PubMed Web of Science ®Google Scholar
• Peng B, Dutreix C, Mehring G. Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion. J Clin Pharmacol 2004a; 44: 158–62
   PubMed Web of Science ®Google Scholar
• Peng B, Hayes M, Resta D. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004b; 22: 935–42
   PubMed Web of Science ®Google Scholar
• Peng B, Lloyd P, Schran H. Clinical pharmacokinetics of imatinib. Clin Pharmacokinet 2005; 44: 879–94
   PubMed Web of Science ®Google Scholar
• Schindler T, Bornman W, Pellicina WT, Miller B, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 2000; 289: 1938–42
   PubMed Web of Science ®Google Scholar
• Szabolcs B, Szakács Z, Csernák O, Barcz L, Nosza B. Cyclodextrin/imatinib complexation: Binding mode and charge dependent stabilities. Eur J Pharm Sci 2007; 30: 167–74
   Google Scholar
• Teoh M, Narayanan P, Moo KS, Radhakrısman S, Pıllappan R, Bukharı N, Segarra I. HPLC determination of imatinib in plasma and tissues after multiple oral dose administration to mice. Pak J Pharm Sci 2010; 23(1)35–41
   Google Scholar
• Velpandian T, Mathur R, Agarwal NK, Arora B, Kumar L, Gupt SK. Development and validation of a simple liquid chromatographic method with ultraviolet detection for the determination of imatinib in biological samples. J Chromatogr B 2004; 804: 431–4
   PubMed Web of Science ®Google Scholar
• Wahlang B, Pawar YB, Bansal AK. Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model. Eur J Pharm Biopharm 2011; 77: 275–82
   PubMed Web of Science ®Google Scholar
• Wang X, Meng M, Gao L, Liu T, Xu Q, Zeng S. Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp. Int J Pharm 2009; 378: 1–8
   PubMed Web of Science ®Google Scholar
• Wang JJ, Sung KC, Hu OY, Yeh CH, Fang JY. Submicron lipid emulsion as a drug delivery system for nalbuphine and its prodrugs. J Control Rel 2006; 115: 140–9
   PubMed Web of Science ®Google Scholar
• Warinoicharoen W, Lansley AB, Lawrence MJ. Nonionic oil in water microemulsions: The effect of oil type on phase behaviour. Int J Pharm 2000; 198: 7–27
   Google Scholar
• Weigel TM, Heerlein-Meinhold I, Bauerschlag DO, Schem C, Bauer M, Jonat W, Maass N, Mundhenke C. Combination of imatinib and vinorelbine enhances cell growth inhibition in breast cancer cells via PDGFR B signaling. Cancer Lett 2009; 273: 70–9
   Google Scholar
• Widmer N, Decosterd LA, Csajka C. Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein. Br J Clin Pharmacol 2006; 62: 97–112
   PubMed Web of Science ®Google Scholar
• Yee S. In vivo permeability across Caco-2 cells can predict in vivo (small intestine) in man-fact or myth. Pharm Res 1997; 14: 763–6
   PubMed Web of Science ®Google Scholar
• Yue Y, San-ming L, Pan D, Da-fang Z. Physicochemical properties and evaluation of microemulsion systems for transdermal delivery of meloxicam. Chem Res Chin Univ 2007; 23(1)81–6
   Google Scholar