Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy

References

• Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol, 2009;41:40–59.
   PubMed Web of Science ®Google Scholar
• Ak T, Gülçin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact, 2008;174:27–37.
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: Problems and promises. Mol Pharm, 2007;4:807–18.
   PubMed Web of Science ®Google Scholar
• Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol, 2010;79:330–8.
   PubMed Web of Science ®Google Scholar
• Anand P, Sundaram C, Jhurani S, Ajaikumar B, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: An “old-age” disease with an “age-old” solution. Cancer Lett, 2008;267:133–64.
   PubMed Web of Science ®Google Scholar
• Anita A, Sreeranganathan M, Chennazhi KP, Lakshmanan VK, Jayakumar R. In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies. Eur J Pharm Biopharm, 2014;88:238–51.
   PubMed Web of Science ®Google Scholar
• Anitha A, Deepa N, Chennazhi KP, Lakshmanan VK, Jayakumar R. Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment. Biochimica et Biophysica Acta, 2014;1840:2730–43.
   PubMed Web of Science ®Google Scholar
• Anitha A, Maya S, Deepa N, Chennazhi KP, Nair SV, Jayakumar R. Curcumin-loaded N,O-carboxymethyl chitosan nanoparticles for cancer drug delivery. J Biomater Sci Polym Ed, 2011;23:1381–400.
   Web of Science ®Google Scholar
• Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev, 2004;56:1649–59.
   PubMed Web of Science ®Google Scholar
• Cheng S, Wu Q, Yang F, Xu M, Leski M, Chen GQ. Influence of DL-beta-hydroxybutyric acid on cell proliferation and calcium influx. Biomacromolecules, 2005;6:593–7.
   PubMed Web of Science ®Google Scholar
• Hazer B, Steinbüchel A. Increased diversification of polyhydroxyalkanoates by modification reactions for industrial and medical applications. Appl Microbiol Biotechnol, 2007;74:1–12.
   PubMed Web of Science ®Google Scholar
• Hazer DB, Kılıçay E, Hazer B. Poly(3-hydroxyalkanoate)s: Diversification and biomedical applications: A state of the art review. Mater Sci Eng C, 2012;32:637–47.
   Web of Science ®Google Scholar
• Hurkat P, Jain A, Jain A, Shilpi S, Gulbake A, Jain SK. Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery. J Nanopart Res, 2012;14:1219.
   Web of Science ®Google Scholar
• Hwang TL, Alijuffali IA, Lin CF, Chang YT, Fang JY. Cationic additives in nanosystems activate cytotoxicity and inflammatory response of human neutrophils: Lipid nanoparticles versus polymeric nanoparticles. Int J Nanomed, 2015;10:371–85.
   PubMed Web of Science ®Google Scholar
• Jeong I, Kim BS, Lee H, Lee KM, Shim I, Kang SK, Yin CS, Hahm DH. Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin induced pain in rats. Int J Pharm, 2009;380:62–6.
   PubMed Web of Science ®Google Scholar
• Khalil NM, Frabel do Nascimento TC, Casa DM, Dalmolin LF, de Mattos AC, Hoss I, Romano MA, Mainardes RM. Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in rats. Colloids Surf B Biointerfaces, 2013;101:353–60.
   PubMed Web of Science ®Google Scholar
• Khalil OAK, de Faria Oliveira OMM, Vellosa JCR, de Quadros AU, Dalposso LM, Karam TK, Mainardes RM, Khalil NM. Curcumin antifungal and antioxidant activities are increased in the presence of ascorbic acid. Food Chem, 2012;133:1001–5.
   Web of Science ®Google Scholar
• Khan TA, Husain Q, Naeem A. A novel and inexpensive procedure for the purification of concanavalin A from Jack Bean (Canavalia ensiformis) extract. Eur J App Sci, 2010;2(2):70–6.
   Google Scholar
• Kılıçay E, Demirbilek M, Türk M, Güven E, Hazer B, Denkbas EB. Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy. Eur J Pharma Sci, 2011;44:310–20.
   PubMed Web of Science ®Google Scholar
• Kumar SSD, Mahesh A, Mahadevan S, Mandal AB. Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. Biochim Biophys Acta, 2014;1840:1913–22.
   PubMed Web of Science ®Google Scholar
• Langer R. New methods of drug delivery. Science, 1990;249:1527–33.
   PubMed Web of Science ®Google Scholar
• Lavigne MD, Górecki DC. Emerging vectors and targeting methods for nonviral gene therapy. Expert Opin Emerg Drugs, 2006;11:541–57.
   PubMedGoogle Scholar
• Lenz RW, Marchessault RH. Bacterial polyesters: Biosynthesis, biodegradable plastics and biotechnology. Biomacromolecules, 2005;6:1–8.
   PubMed Web of Science ®Google Scholar
• Liu J, Xu L, Liu C, Zhang D, Wang S, Deng Z, Lou W, Xu H, Bai Q, Ma J. Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake. Carbohydr Polym, 2012;90:16–22.
   PubMed Web of Science ®Google Scholar
• Liu M, Kono K, Fréchet JMJ. Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents. J Control Release, 2000;65:121–31.
   PubMed Web of Science ®Google Scholar
• Liu Y, Li K, Liu B, Feng SS. A strategy for precision engineering of nanoparticles of biodegradable copolymers for quantitative control of targeted drug delivery. Biomaterials, 2010;31:9145–55.
   PubMed Web of Science ®Google Scholar
• Lu XY, Zhang Y, Wang L. Preparation and in vitro drug-release behavior of 5-fluorouracil-loaded poly(hydroxybutyrateco-hydroxyhexanoate) nanoparticles and microparticles. J Appl Polym Sci, 2010;116:2944–50.
   Web of Science ®Google Scholar
• Ma Y, Sadoqi M, Shao J. Biodistribution of indocyanine green-loaded nanoparticles with surface modifications of PEG and folic acid. Int J Pharma, 2012;436:25–31.
   PubMed Web of Science ®Google Scholar
• Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci, 2006;78:2081–7.
   PubMed Web of Science ®Google Scholar
• Masood F, Chen P, Yasin T, Fatima N, Hasan F, Hameed A. Encapsulation of Ellipticine in poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) based nanoparticles and its in vitro application. Mater Sci Eng C Mater Biol Appl, 2013;33:1054–60.
   PubMed Web of Science ®Google Scholar
• Mishra VK, Mohammada G, Mishra SK. Down regulation of telomerase activity may enhanced by nanoparticle mediated curcumin delivery. Digest J Nanomater Biostruct, 2008;3:163–9.
   Web of Science ®Google Scholar
• Misra R, Sahoo SK. Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy. Eur J Pharm Sci, 2010;39:152–63.
   PubMed Web of Science ®Google Scholar
• Mo Y, Lim LY. Preparation and in vitro anticancer activity of wheat germ agglutinin (WGA)-conjugated PLGA nanoparticles loaded with paclitaxel and isopropyl myristate. J Cont Rel, 2005;107:30–42.
   PubMed Web of Science ®Google Scholar
• Mohanty C, Sahoo SK. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials, 2010;31:6597–611.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene, 2001;20:7597–609.
   PubMed Web of Science ®Google Scholar
• Mun SH, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS, Kim YC, Lee DS, Shin DW, Kweon KT, et al. Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine, 2013;20:714–18.
   PubMed Web of Science ®Google Scholar
• Qu XH, Wu Q, Liang J, Qu X, Wang SG, Chen GQ. Enhanced vascular-related cellular affinity on surface modified copolyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx). Biomaterials, 2005;26:6991–7001.
   PubMed Web of Science ®Google Scholar
• Qu XH, Wu Q, Chen GQ. In vitro study on hemocompatibility and cytocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). J Biomater Sci Polymer Edn, 2006;17(10):1107–21.
   Web of Science ®Google Scholar
• Reusch RN. Transmembrane ion transport by polyphosphate/poly (R)-3-hydroxybutyrate complexes. Biochemistry, 2000;65(3):280–95.
   PubMed Web of Science ®Google Scholar
• Russell-Jones GJ, Veitch H, Arthur L. Lectin-mediated transport of nanoparticles across Caco-2 and OK cells. Int J Pharm, 1999;190:165–74.
   PubMed Web of Science ®Google Scholar
• Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Madmaev V, Aggarwal BB. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate antiinflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis, 2007;28:1765–73.
   PubMed Web of Science ®Google Scholar
• Shah M, Naseer MI, Choi MH, Kim MO, Yoon SC. Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: Preparation, characterization and in vitro evaluation. Int J Pharm, 2010;400:165–75.
   PubMed Web of Science ®Google Scholar
• Shaikh J, Ankola DD, Beniwal V, Singh MN, Kumar D. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci, 2009;37:223–30.
   PubMed Web of Science ®Google Scholar
• Shan C, Qiong W, Yan Z, Bing Z, Qiang CG. Effect of poly(hydroxybutyrate-co hydroxyhexanoate) microparticles on growth of murine fibroblast L929 cells. Polym Degrad Stabil, 2006;91:3191–6.
   Web of Science ®Google Scholar
• Shi Z, Chen J, Li CY, An N, Wang ZJ, Yang SL, Huang KF, Bao JK. Antitumor effects of concanavalin A and Sophora flavescens lectin in vitro and in vivo. Acta Pharmacologica Sinica, 2014;35:248–56.
   PubMed Web of Science ®Google Scholar
• Sun J, Dai ZW, Zhao Y, Chen GQ. In vitro effect of oligo-hydroxyalkanoates on the growth of mouse fibroblast cell line L929. Biomaterials, 2007;28:3896–903.
   PubMed Web of Science ®Google Scholar
• Tang J, Liu Y, Yin P, Yao G, Yan G, Deng C, Zhang X. Concanavalin A-immobilized magnetic nanoparticles for selective enrichment of glycoproteins and application to glycoproteomics in hepatocelluar carcinoma cell line. Proteomics, 2010;10:2000–14.
   PubMed Web of Science ®Google Scholar
• Udompornmongkol P, Chiang BH. Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications. J Biomater Appl, 2015;30:537--46.
   PubMed Web of Science ®Google Scholar
• Verderio P, Bonetti P, Colombo M, Pandolfi L, Prosperi D. Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. Biomacromolecules, 2013;14:672–82.
   PubMed Web of Science ®Google Scholar
• Wang YW, Wu Q, Chen GQ. Reduced mouse cell growth by increased hydrophilicity of microbial polyhydroxyalkanoates via hyaluronan coating. Biomaterials, 2003;24:4621–9.
   PubMed Web of Science ®Google Scholar
• Wiggam MI, O’Kane MJ, Harper R, Atkinson AB, Hadden DR, Trimble ER, Bell PM. Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. Diabetes Care, 1997;20(9):1347–52.
   PubMed Web of Science ®Google Scholar
• Xiong YC, Yao YC, Zhan XY, Chen GQ. Application of polyhydroxyalkanoates nanoparticles as intracellular sustained drug-release vectors. J Biomater Sci, 2010;21:127–40.
   PubMed Web of Science ®Google Scholar
• Zhao P, Wang H, Yu M, Liao Z, Wang X, Zhang F, Ji W, Wu B, Han J, Zhang H, et al. Paclitaxel loaded folic acid targeted nanoparticles of mixed lipid-shell and polymer-core: In vitro and in vivo evaluation. Eur J Pharm Biopharm, 2012;81:248–56.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Zou B, Shi ZY, Wu Q, Chen GQ. The effect of 3-hydroxybutyrate on the in vitro differentiation of murine osteoblast MC3T3-E1 and in vivo bone formation in ovariectomized rats. Biomaterials, 2007;28:3063–73.
   PubMed Web of Science ®Google Scholar
• Zinn M, Witholt B, Egli T. Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev, 2001;53:5–21.
   PubMed Web of Science ®Google Scholar