Application of ¹H-N.M.R. to the design of liposomes for oral use. Synergistic activity of bile salts and pancreatic phospholipase A₂ in the induced permeability of small unilamellar phospholipid vesicles

References

• Allegrini P. R., Van Scharrenburg G., de Hass G. H., Seelig J. 1H and 31P-NMR studies of bilayers composed of 1-acyl lysophosphatidylcholine and fatty acids. Biochimica et Biophysica Acta 1983; 731: 448–455
   Google Scholar
• Bhrgflson L. D. Paramagnetic hydrophilic probes in NMR investigations of membrane systems. Methods in Membrane Biology, E. D. Korn. Plenum Press, NY 1978; Volume 9: 275–335
   Google Scholar
• Blackberg L., Hernell O., Olivecrona T. Hydrolysis of human milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2 and bile salts. Journal of Clinical Investigation 1981; 67: 1748–1752
   PubMed Web of Science ®Google Scholar
• Cullis P. R., De Kruijff B. Lipid polymorphism and the functional roles of lipids in biological membranes. Biochimica et Biophysica Acta 1979; 559: 399–420
   PubMed Web of Science ®Google Scholar
• Cullis P. R., De Kruijff, Hope M. J., Nayar R., Schmid S. L. Phospholipids and membrane transport. Canadian Journal of Biochemistry 1980; 58: 1091–1100
   PubMedGoogle Scholar
• Liposomes in Biological Systems, G. Gregoriadis, A. C. Allison. John Wiley, Chichester 1980
   Google Scholar
• Hashimoto A., Hawada J. Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats: Preliminary study. Endocrinologia Japanica 1979; 26: 237–344
   Google Scholar
• Hunt G. R. A. A comparison of Triton X-100 and the bile salt taurocholate as micellar ionophores or fusogens in phospholipid vesicular membranes. FEBS Letters 1980; 119: 132–136
   PubMedGoogle Scholar
• Hunt G. R. A., Jawaharlal K. A 1H-NMR investigation of the mechanism for the ionophore activity of the bile salts in phospholipid vesicular membranes and the effect of cholesterol. Biochimica et Biophysica Acta 1980; 601: 678–684
   PubMedGoogle Scholar
• Hunt G. R. A., Jones I. C. Lanthanide ion transport across phospholipid vesicular membranes: a comparison of alamethicin 30 and A23187 using 1H-NMR spectroscopy. Bioscience Reports 1982; 2: 921–928
   PubMedGoogle Scholar
• Hunt G. R. A., Jones I. C. A 1H-NMR investigation of the effects of ethanol and the general anaesthetics on ion-channels and membrane fusion using unilamellar phospholipid membranes. Biochimica et Biophysica Acta 1983; 736: 1–10
   PubMedGoogle Scholar
• Hunt G. R. A., Tipping L. R. H., Belmont M. R. Rate-determining processes in the transport of Pr3+ ions by the ionophore A23187 across phospholipid vesicular membranes. A 1H-NMR and theoretical study. Biophysical Chemistry 1978; 8: 341–355
   PubMedGoogle Scholar
• Hutton W. C., Yeagle P. L., Martin R. B. The interaction of lanthanide and CA2+ salts with phospholipid bilayer vesicles: the validity of the NMR method for determination of vesicle bilayer phospholipid surface ratios. Chemistry and Physics of Lipids 1977; 19: 255–265
   PubMedGoogle Scholar
• Jain M. K., De Haas G. H. Structure of 1-acyl lysophosphatidylcholine and fatty acid complex in bilayers. Biochimica et Biophysica Acta 1981; 642: 203–211
   PubMedGoogle Scholar
• Jain M. K., Egmond M. R., Verheij H. M., Apitz-Castro R., Dijkman R., De Haas G. H. Interaction of phospholipase A2 and phospholipid bilayers. Biochimica et Biophysica Acta 1982; 688: 341–348
   PubMedGoogle Scholar
• Liposomes: From Physical Structure to Therapeutic Applications, C. G. Knight. Elsevier North-Holland Biomedical Press, Amsterdam 1981
   Google Scholar
• Liao M. J., Prestegard J. H. Fusion kinetics of phosphatidylcholine phosphatidic acid mixed lipid vesicles. A 1H-NMR study. Biochimica et Biophysica Acta 1980; 559: 81–94
   Google Scholar
• Machy P., Leserman L. D. Small liposomes are better than large liposomes for specific drug delivery in vitro. Biochimica et Biophysica Acta 1983; 730: 313–320
   PubMed Web of Science ®Google Scholar
• Nalbone G., Lairon D., Charbonnier-Augeire M., Vigne J-L., Leonardi J., Chabert C., Hauton J. C., Verger R. Pancreatic phospholipase A2 EC-3.1.1.4 hydrolysis of phosphatidylcholines in various physiochemical states. Biochimica et Biophysica Acta 1980; 620: 612–626
   PubMedGoogle Scholar
• Patel H. M., Harding N. G. L., Logue F., Kessor C., MacCuish A. C., Mackenzie J. C., Ryman B. E., Scobie I. Intrajejunal absorption of liposomally entrapped insulin in normal man. Biochemical Society Transactions 1978; 6: 784–785
   PubMedGoogle Scholar
• Rowland R. N., Woodley J. F. The stability of liposomes in vitro to pH, bile salts and pancreatic lipase. Biochimica et Biophysica Acta 1980; 620: 400–409
   PubMed Web of Science ®Google Scholar
• Ryman B. E., Tyrrell D. A. Liposomes—bags of potential. Essays in Biochemistry, P. N. Campbell, R. D. Marshall. Academic Press. 1980; Volume 16: 49–98
   Google Scholar
• Slotboom A. J., Verheij H. M., de Haas G. H. On the mechanism of phospholipase A2. Phospholipids, J. N. Hawthorne, G. B. Ansell. Elsevier Biomedical Press. 1982; 359–434
   Google Scholar
• Van der Steen A. T. M., de Jong W. A. L., De Kruijff B., van Deenen L. L. M. Lipid dependence of glycophorin-induced transbilayer movement of lysophosphatidylcholine in large unilamellar vesicles. Biochimica et Biophysica Acta 1981; 647: 63–72
   Google Scholar
• Van Zoelen E. J. J., De Kruijff B., Van Deenen L. L. M. Protein-mediated transbilayer movement of lysophosphatidylcholine in glycophorin-containing vesicles. Biochimica et Biophysica Acta 1978; 508: 97–108
   PubMedGoogle Scholar
• Yatvin M. B., Lelkes P. I. Clinical prospects for liposomes. Medical Physics 1982; 9: 149–175
   PubMed Web of Science ®Google Scholar