Patent Briefing

Patent Briefing

BELGIUM

• Belgian Brevet 898,708 (1984) Diagnostic composition containing complexes A.-G. Schering. Complexes of an organic acid may be rendered specific for certain organs by coupling with biomolecules such as liposomes and are useful for NMR imaging and X-ray contrast agents.
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BRAZIL

• Brazilian Pedido 83 06,785 (1984) Stabilized plurilamellar vesicles. A new type of liposome LIPOSOME CO. INC. R. P. Lenk, M. W. Fountain, A. S. Janoff, M. J. Ostro and M. C. Popescu. Stabilized plurilamellar vesicles which contain up to 100 lipid bilayers are better than ordinary liposomes for drug delivery for treatment of brucellosis of cattle, eye infections and viral lymphocytic meningitis.
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CANADA

• Canadian Patent 1,163,496 (1984) Food supplement concentrate in a dense glasseous extrudate GRIFFITH LABORATORIES U.S.A., INC. L. Sair and R. A. Sair. Food additives may be microncapsulated and formed into a homogeneous microdispersion. Encapsulated lemon flavouring released 78 per cent of citric acid when tested in tea bags.
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CZECHOSLOVAKIA

• Czech Patent 214,214 (1984) Solid medicinal microforms containing a liquid effective component K. Koblas, E. Likarova, J. Lukac, E. Pavlovska and J. Sajvera. The prepatation of solid drug microdragees containing a liquid pharmaceutical is described.
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EUROPE

• European Patent Application 106,370 (1984) Specific binding assays utilizing analyte-cytolysin conjugates DU PONT DE NEMOURS, E. I. AND CO. W. J. Freytag and W. J. Litchfield. A rapid and sensitive membrane lytic assay is described for the detection of low concentrations of analytes, using lipid vesicles, erythrocytes or their ghosts containing detectable markers.
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• European Patent Application 109,838 (1984) Light- and heat-sensitive recording material FUJI PHOTO FILM CO. LTD. T. Usami, T. Tanaka and M. Satomura. The title material is a support coated with a microencapsulated colour former and a colour forming agent. Exposure to light causes hardening of the encapsulated material. Heating causes colour formation in the unexposed areas.
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• European Patent Application 113,309 (1984) Syndiotactic 1,2-polybutadiene synthesis GOODYEAR TIRE AND RUBBER CO. J. J. Barbour, A. J. Bell, K. W. Donbar and J. N. Henderson. The title compound was prepared utilizing a microencapsulated catalyst.
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• European Patent Application 117,605 (1984) Minute capsules APPLETON PAPERS INC. R. W. Brown and R. P. Bowman. Pressure-sensitive copying materials were prepared using microencapsulated chromagenic materials.
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FRANCE

• French Demande 2,531,718 (1984) Reagent permitting a determination of a very high sensitivity of an antigen characteristic of the hepatitis B virus in human biological fluids SANOFI. J. E. L. Duheille, B. C. Pau and P. M. Gros. A reagent consisting of spherical hydrophilic polyfunctional microparticles for the detection of hepatitis B surface antigen in human serum was prepared.
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• French Demande 2,540,381 (1984) Cosmetic and pharmaceutical composition for cell growth stimulation PARFUMS CHRISTIAN DIOR S. A. G. Redziniak and A. Meybeck. Cell growth may be stimulated by preparations of peptides or polypeptides contained in liposomes. The composition was applied to the human face for eight days.
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F.R. GERMANY

• German Offenlegungsschrift 3,330,679 (1984) Recording material containing iron salts KANZAKI PAPER MFG. CO. LTD. S. Shioi, G. Matoba and M. Miyake. A copying paper undersheet having outstanding whiteness was prepared. In combination with a microencapsulated oversheet, a colour image with d = 0.95 was obtained.
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• German Offenlegungsschrift 3,332,621 (1984) Microcapsule toner for electrophotography CANON K. K. T. Nakahara, I. Ohsaki and H. Ushiyama. A microcapsule toner for electrographic electrostatic printing and electrophotography with excellent pressure-fixing characteristics and good physical stability was prepared.
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• German Offenlegungsschrift 3,335,174 (1984) Hot meltable and cold hardenable microcapsule-enclosed printing ink MITSUBISHI PAPER MILLS LTD. T. Iida, H. Senoh and F. Okumura. The title ink was prepared containing microcapsules with improved dispersability in wax carriers for use in carbonless copying paper.
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• German Offenlegungsschrift 3,336,411 (1984) Electrostatographic toner material FUJI PHOTO FILM CO. LTD. T. Mikami. A pressure-fixable electrostatographic developer containing encapsulated toner particles gave sharp images that were well fixed to paper.
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• German Offenlegungsschrift 3,401,056 (1984) Microcapsule-containing adhesive KUREHA CHEMICAL INDUSTRY CO. LTD. Y. Igarashi and M. Takahashi. Microencapsulated chemical-reaction or solvent-activated adhesives are prepared.
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• German Offenlegungsschrift 3,341,760 (1984) Composition with phagocyte controlling action MOCHIDA PHARMACEUTICAL CO. LTD. H. Ohnishi, H. Kosuzume, Y. Suzuki and E. Mochida. Liposomes containing human pepsin and/or pepsin-like enzyme are useful for the treatment of infections, gout and atherosclerosis.
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• German Offenlegungsschrift 3,345,314 (1984) Oligomeric hydrocarboxylic acid derivatives and their use SANDOZ-PATENT G.M.B.H. J. Franz, W. Prikoszovich and Z. Brich. The preparation and use of polymers of hydroxycarboxylic acids esterified with sterols for the microencapsulation of low-release pharmaceuticals is described.
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GERMAN DEMOCRATIC REPUBLIC

• German D.R. Patentschrift 207,861 (1984) Nuclear fuels with adjustable porosity AKADEMIE DER WISSENSCHAFTEN DER DDR. 11. J. Engelman. A process is described for the production of 1.302/C rnicrospheres for use in high temperature reactors.
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• German DR Patentschrift 210,353 (1984) Included volume of liposomes ANADEM/E DER WISSENSCHAFTEN DER DDR, ZENTRALINSTITUT FUER 1SOTOPEN UND sraAHLENFoascHuNG. G. Vorwieger. A rapid method for the determination of the included volume of liposomes is described.
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JAPAN

• Japan Kokai Tokkyo Koho 58 116,192 (1983) Single sheet type pressure-sensitive copying paper KANZAKI PAPER MFG CO. LTD. The title paper has a layer of microencapsulated colour-formers and a colour-developer layer with thermally expandable particles which produce a stilted surface. This reduces blemishes and improves printability.
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• Japan Kokai Tokkyo Koho 58 136,049 (1983) Electrophotographic microencapsulated toners CANON K. K. Electrophotographic microencapsulated toner particles having a discontinuous coating produce a toner with improved fixing properties.
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• Japan Kokai Tokkyo Koho 58 136,050 (1983) Electrophotographic microcapsule toners CANON K. K. A microencapsulated electrophotographic toner with improved fixing properties was prepared.
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• Japan Kokai Tokkyo Koho 58 144,838 (1983) Microencapsulated pressure-fixable toner TOSHIBA CORP. The preparation of a microencapsulated toner for electrophotography which is pressure-fixable at low pressure is described.
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• Japan Kokai Tokkyo Koho 58 211,165 (1983) Electrophotographic microcapsule toners CANON K. K. Electrophotographic microcapsule toners with excellent fixability were prepared.
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• Japan Kokai Tokkyo Koho 58 211,488 (1983) Pressure-sensitive photothermographic materials FUJI PHOTO FILM CO. LTD. A pressure-sensitive photothermographic imaging material is comprised of a support with a microencapsulated vinyl compound, a photopolymerization initiator, a foaming agent and a colour-forming component composition.
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• Japan Kokai Tokkyo Koho 58 221,849 (1983) Toner for development CANON K. K. A microencapsulated toner was resistant to caking on transfer to a high quality paper by pressure fixing.
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• Japan Kokai Tokkyo Koho 58 221,850 (1983) Electrophotographic developers and process CANON K. K. Electrophotographic developers containing toners and microencapsulated additives, which are gradually released, have excellent durability.
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• Japan Kokai Tokkyo Koho 58 19,193 (1984) Thermosensitive recording paper MITSUBISHI PAPER MILLS urn. A thermosensitive recording paper is coated with microencapsulated leuco dyes, a developer and a wax which melts on heating. A solvent-resistant clear black image was produced.
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• Japan Kokai Tokkyo Koho 59 31,786 (1984) Phosphatidylcholine-type phospholipids H. Tsuchida. The title compounds were prepared for use as microcapsule (liposome) materials.
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• Japan Kokai Tokkyo Koho 59 33,287 (1984) Phospholipid liposomes including symmetric porphyrin metal complexes H. Tsuchida. Phospholipid liposomes including symmetric porphyrin metal complexes were prepared for use as oxygen absorbing—desorbing agents.
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• Japan Kokai Tokkyo Koho 59 36,540 (1984) Food microcapsules with gelatin film for storage AJINOMOTO CO. INC. Non- or semi-hardened gelatin microcapsules are coated to prevent agglomeration and ensure solubility in water.
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• Japan Kokai Tokkyo Koho 59 46,124 (1984) Microcapsules JAPAN OXYGEN CO. LTD. Powdered core substances, liquid at ordinary temperatures, or which form lumps, are pulverized and microencapsulated at low temperatures. A microencapsulated acrylate adhesive was prepared.
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• Japan Kokai Tokkyo Koho 59 46,126 (1984) Microencapsulation of chelating agents for pressure-sensitive copying systems KANZAKI PAPER MFG CO. LTD. Microcapsules useful for pressure-sensitive copying systems based on metal chelate formation reactions were prepared.
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• Japan Kokai Tokkyo Koho 59 48,772 (1984) Encapsulated toner CANON K. K. The preparation of a microencapsulated electrophotographic toner is described.
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• Japan Kokai Tokkyo Koho 59 87,034 (1984) Aqueous suspension containing microcapsules TOA GOSEI CHEMICAL INDUSTRY CO. LTD. Polynuclear microcapsules for agricultural chemicals were prepared.
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• Japan Kokai Tokkyo Koho 59 66,425 (1984) Microcapsules production using biodegradable polymers MITSUI TOATSU CHEMICALS INC. The preparation of 5-fluorouracil microcapaules which do not aggregate during storage is described.
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• Japan Kokai Tokkyo Koho 59 70,438 (1984) Shell-mold core with improved knockout properties 0. Madono. The knock-out of phenolic resin-bound sand mould cores is facilitated by the addition of a microencapsulated thermally decomposable powdered foaming agent.
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• Japan Kokai Tokkyo Koho 59 73,510 (1984) Improved cosmetic makeups containing microcapsules POLA CHEMICAL INDUSTRIES INC. MATSUMOTO YUSHI SEIVAKU CO. LTD. Cosmetics containing microen-capsulated skin-softening agents, perfumes etc., were prepared.
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• Japan Kokai Tokkyo Koho 59 87,036 (1984) Microencapsulation JUJO PAPER MFG. CO. LTD. Melanine-formaldehyde or urea-formaldehyde microcapsules of narrow size distribution, useful in pressure-sensitive copying papers, were prepared.
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• Japan Kokai Tokkyo Koho 59 95,928 (1984) Microencapsulated liquid pesticide NITTO ELECTRIC INDUSTRIAL CO. LTD. The preparation of a microencapsulated liquid pesticide is described.
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• Japan Kokai Tokkyo Koho 59 96,989 (1984) Ink composition for pressure-sensitive copying paper DAINIPPON PRINTING CO. LTD. Inks prepared by dispersing microencapsulated colouring agents in varnishes are pressure-sensitive and resistant to abrasion.
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• Japan Kokai Tokkyo Koho 59 104,991 (1984) Pressure-sensitive copying sheets FUJI XEROX CO. LTD. Copying sheets with a microencapsulated colour forming dye gave reduced curling and good running quality in an electrophotographic copier.
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• Japan Kokai Tokkyo Koho 59 106,423 (1984) Liposomes from glycolipids H. Saida. Liposomes prepared from synthetic glycolipids may be used as drug carriers.
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• Japan Kokai Tokkyo Koho 59 113,434 (1984) Silver halide photographic materials KONISHIROKU PHOTO INDUSTRY CO. LTD. The title materials contain microcapsules of pigment in alkali-soluble wall material and a layer bleached by development giving no damage on image characteristics.
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• Japan Kokai Tokkyo Koho 59 116,228 (1984) Preparation of liposomes containing blood coagulation factor VIII GREEN CROSS CORP. The preparation of liposomes containing blood coagulation factor VIII for use in the treatment of haemophilia is described.
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• Japan Kokai Tokkyo Koho 59 125,977 (1984) Fiber finishing agents NISSHIN SPINNING CO. LTD. Shinko Yushi K. K. Fibre finishing agents contain microencapsulated silicone oil and a surfactant antistatic agent to give finished yarns antistatic properties and good smoothness.
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• Japan Kokai Tokkyo Koho 59 131,355 (1984) Soft capsules containing microcapsules MOR1SHITA JINTAN CO. LTD. FUJISAWA PHARMACEUTICAL CO. LTD. The preparation of microcapsule-containing capsules for controlling the rate of gastric and enteric drug absorption is described.
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• Japan Kokai Tokkyo Koho 59 137,409 (1984) Liposomes containing benzodiazepines GREEN CROSS CORP. Liposomes containing benzodiazepines are readily absorbed by the rectum and have high affinity for tumours.
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• Japan Kokai Tokkyo Koho 59 139,317 (1984) Sustained-release formulations containing nifedipine TKISAN SE1YAKU K. K. Enteric-coated gelatin microcapsules containing nifedipine were prepared.
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• Japan Kokai Tokkyo Koho 59 152,321 (1984) Preparation of liposomes containing drugs TANABE SEIYAKU CO. LTD. The addition of NaCl buffers or sugars to liposomes containing drugs improves the stability of the drugs and the uptake of drugs by the liposomes.
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• Japan Kokai Tokkyo Koho 59 157,033 (1984) Preparation of erythrocyte ghost membrane liposomes as drug carriers H. Tsuchida. The preparation of liposomes from erythrocyte ghost membranes and their use as pharmaceutical carriers is described.
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• Japan Kokai Tokkyo Koho 58 199,187 (1983) Coating of microcapsules on supports DAINIPPON PRINTING CO. LTD. When the supoort is first coated with a tacky substance before coating with microcapsules, the process is quicker than when a microcapsule dispersion is used. Tackiness disappears after storage for three hours.
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• Japan Tokkyo Koho 58 27,119 (1983) Pressure-sensitive copying systems KANZAKI PAPER MFG. CO. LTD. Pressure-sensitive sheet for copying system is prepared from microcapsules containing N-compounds with improved heat resistance.
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• Japan Tokkyo Koho 58 29,751 (1983) Pressure sensitive copying paper KANZAKI PAPER MFG. CO. LTD. A pressure-sensitive sheet for a copying system was prepared containing filler particles which reduce blemishes by handling.
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• Japan Tokkyo Koho 58 38,781 (1983) Preparation of pressure-fixing type microcapsule toners RICOH CO. LTD. The preparation of electrostatographic microcapsule toners with excellent fixability is described.
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• Japan Tokkyo Koho 58 57,102 (1983) Heat fixable microencapsulated electrophotographic toners RICOH CO. LTD. A microencapsulated toner providing offset-free images and which does not cause paper rolling on the heat-fixing roller was prepared.
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• Japan Tokkyo Koho 58 57,106 (1983) Microencapsulated toner for electrophotography RICOH CO. LTD. A microencapsulated electrophotographic toner containing truly spherical particles was prepared.
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• Japan Tokkyo Koho 59 16,654 (1984) Pressure measuring sheets FUJI PHOTO FILM CO. LTD. The sheets were prepared from two layers of microcapsules containing colour former in different amounts and a layer of colour developer. The colouring concentration of the sheet varies with pressure.
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• Japan Tokkyo Koho 59 27,610 (1984) Microcapsules AGENCY OF INDUSTRIAL SCIENCES AND TECHNOLOGY. A method for rapidly preparing microcapsules of narrow diameter distribution, around 40 ft, and selective adsorption-for urea, ammonia and lower amines is described.
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THE NETHERLANDS

• Netherlands Application 82 03,963 (1984) Aromatizing dry plant material such as tea and tobacco NAARDEN INTERNATIONAL N.v. Particles of plant material are coated with microencapsulated aroma materials using an adhesive solution.
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PCT

• PCT Application 84 02,270 (1984) Microfine particles having target-seeking properties AKTIEBOLAG LEO. M. Yoshida, M. Asano, I. Kaetsu, K. Nakai, H. Yamanaka and K. Shida. Target-seeking microfine particles were prepared which slowly release the entrapped cancer control agent.
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• PCT Application 84 02,579 (1984) Lipid-vesicle-surface assay reagent and method COOPER-LIPOTECH, INC. F. J. Martin and P. E. Huertas. EIA reagents consisting of lipid vesicles coated with ligand and enzyme molecules were used to determine antibodies on erythrocytes and antibodies to rubella.
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SWITZERLAND

• Swiss Patentschrift 642,851 (1984) Triiodothyroacetic acid and glycosaminoglycan compositions for the treatment of cellulitis BEREMA S. A. S. Curri. Liposomes containing both title compounds are more efficient in the treatment of cellulitis than either compound alone.
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UK

• UK Patent Application 2,131,767 (1984) Marking packaging WIGGINS TEAPE GROUP LTU. P. Sinclair. A paper or plastic film coated with microencapsulated colour former, binder and filler produces images on application of pressure, heat, u.v. light or laser energy for use in marking materials.
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USA

• US Patent 4,448,445 (1984) Pressure-sensitive record system WALLACE COMPUTER SERVICES INC. J. C. H. Chang and T. Dimitriou. A pressure-sensitive copying system is described requiring fewer coatings to form a multiple business form than a transfer copy system.
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• US Patent 4,460,560 (1984) Drug delivery by polymeric carriers UNIVERSITY OF SOUTHERN CALIFORNIA. Z. A. Tokes, K. E. Rogers and A. Rembaum. Anthrocyclinone antitumour drugs, when covalently bound to polymer particles of diameter 0.5 it, produce drugs with enhanced cystostatic activity which is retained after repeated uses.
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• US Patent 4,460, 577 (1984) Purification of pharmaceutical liposomes FARMITALIA CARLO ERRA S.P.A. L. Moro, G. Neri and A. Rigamonti. A method for removing nonentrapped drugs from liposome suspensions is described.
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• US Patent 4,469,623 (1984) Detection of articles MINNESOTA MINING AND MFG co. R. D. Danielson and R. A. Prokop. Vapour permeable microcapsules containing C8F17Br, which can be detected by a gas electron-capture detector, may be incorporated in explosives for their detection.
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USSR

• USSR Patent 1,112,056 (1984) Microencapsulated lipase MOSCOW STATE UNIVERSITY. R. B. Aisina, N. B. Demina, N. F. Kazanskaya, V. Ya. Lebendenko, A. I. Tentsova, M. M. Rakhimov and K. Davranov. The preparation of microencapsulated lipase is described.
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