PATENT BRIEFING
BELGIUM
- Belgian Patent 903,463 (1986) Microencapsulation of drugs DEBIOPHARM S. A. A process for the microencapsulation of drugs eliminates aggregation and gives microcapsules with very low content of undesirable organic compounds.
CANADA
- Canadian Patent 1,195,249 (1985) Liposomes containing steryl glucosides NIPPON SHIN YAKU CO., LTD. M. Kawamata, K. Ushimaru and S. Yamane. Steryl glucosides in liposomes in injection solutions are useful for strengthening blood vessels and treating shock. The haemostatic activity of the solutions was demonstrated in mice.
CZECHOSLOVAKIA
- Czech Patent 227,755 (1985) Microparticles labelled by radionuclides Z. Kallay, L. Soltes, I. Novak, T. Trnovec and D. Berek. The preparation of a material useful in medical diagnostics, by impregnating porous silica microparticles with a radionuclide, is described.
EUROPE
- European Patent Application 144,472 (1985) Clay mineral-type color developer composition for pressure-sensitive recording sheets MIGUSAWA INDUSTRIAL CHEMICALS, LTD. K. Usui, M. Ogawa, T. Sato, Y. Mizoguchi, N. Yamada and N. Takahashi. A colour-developing clay composition was used to develop colour in microencapsulated pressure-sensitive copying sheets.
- European Patent Application 149,557 (1985) Partially pressure-sensitive recording paper KUREHA CHEMICAL INDUSTRY CO., LTD. Y. Okada and Y. Igarashi. A pressure-sensitive copying paper is only partially coated with pressure-rupturable colour-forming-containing microcapsules thus obviating the need for a reducer ink to desensitize the areas not to be copied.
- European Patent Application 161,091 (1985) Fragrance-releasing pull-apart sheet MINNESOTA MINING AND MFG CO., LTD. N. P. Sweeny, 0. F. Wienke and J. W. Charbonneau. Microencapsulated fragrance materials are secured between two paper surfaces in such a way that when the papers are separated the capsules are ruptured.
- European Patent Application 164,931 (1985) Photosensitive microcapsules, photosensitive materials utilizing these microcapsules and imaging processes using such materials MEAD CORP. P. C. Adair and A. L. Burkholder. Photosensitive microcapsules useful in the formation of polychromatic images were prepared.
- European Patent Application 165,799 (1985) Microparticles having crosslinking reaction NIPPON PAINT CO., LTD. K. Kanda, S. Ishikura, K. Ishii and A. Kashihara. The preparation of polymeric microparticles containing a chemically bound promoter for crosslinking reactions useful in curable coating compositions, printing inks, etc. is described.
- European Patent Application 166,454 (1986) Solvent for the dye of a pressure-sensitive recording paper NIPPON PETROCHEMICALS CO. LTD. S. Kawakami, E. Matsuzaka, S. Narui and N. Takahashi. A solvent comprising mainly diarylalkanes b.p. 275-320°C was used in the making of a colourless dye precursor during its microencapsulation for use in a pressure-sensitive recording paper.
- European Patent Application 168,652 (1986) Poly(phenylene oxide) blends containing ionomeric rubbers GENERAL ELECTRIC CO. J. R. Campbell and P. M. Conroy. A composition of poly(phenylene oxide), an elastomer and a plasticizer has good impact resistance and structural integrity.
- European Patent Application 170,247 (1986) Hemoglobin-containing liposomes TERUMO CORP. K. Suzuki and Y. Miyauchi. Artificial blood with high oxygen-carrying ability contains haemoglobin encapsulated in a phospholipid.
- European Patent Application 170,642 (1986) Liposomes containing steroid esters DRACO A. B. B. I. Axelsson, R. L. Brattsand, C. M. Dahlbaeck, L. A. Kaellstroem and J. W. Trofast. Liposomes ‘, 2 jm containing steroid esters can be used for treating and controlling inflammation of the respiratory tract. They completely prevented induced lung oedema in rats.
- European Patent Application 171,039 (1986) Solvent for the dye of pressure-sensitive recording paper NIPPON PETROCHEMICALS CO., LTD. A. Sato, K. Endo, S. Kawakami, E. Matsuzaka and S. Narui. The preparation of microcapsules for pressure-sensitive recording paper is described.
- European Patent Application 171,710 (1986) Liposome composition SHIONOGI AND CO., LTD. H. Jizomoto. The preparation of liposome compositions retaining large amounts of drugs in small amounts of phospholipid is described.
- European Patent Application 177,000 (1986) Sustained release formulation of water-soluble components EURAND ITALIA s.p.A. M. Calanchi and L. Gentilini. A method is described for extending the release of water-soluble microencapsulated drugs for up to 12 hours when dissolved in water or gastrointestinal juices.
- European Patent Application 177,223 (1986) Pharmaceutical multiphase composition M. Mezei. A pharmaceutical composition showing good disposition on the skin of guinea-pigs contains liposome encapsulated drugs which are only slightly water-soluble, a saturated solution of the drug and the drug in solid form.
- European Patent Application 179,444 (1986) Micellular particle compositions encapsulating imaging and chemotherapeutic agents for tumors CITY OF HOPE NATIONAL MEDICAL CENTER; VESTAR RESEARCH, INC. C. A. Presant, R. T. Proffitt, R. L. Teplitz, L. E. Williams and G. W. Y. Tin. The preparation is described of micellular particle compositions containing imaging agents or chemotherapeutic agents for delivery to tumours for diagnosis and treatment.
FRANCE
- French Demande 2,564,319 (1985) Novel liposome composition for cell proliferation INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM). P. Machy and L. D. Leserman. The preparation of a liposome composition useful for assuring cell survival during proliferation in the presence of an inhibitor is described, also the use of liposomes in gene cloning.
- French Demande 2,567,418 (1986) Microcapsules for pressure-sensitive recording materials MITSUBISHI PAPER MILLS, LTD. T. Kosaka, F. Okumura and H. Tsukahera. A pressure-sensitive recording paper was prepared that contained a coating of microencapsulated hydrophobic material.
FR GERMANY
- German Offenlegungsschrift 3,424,115 (1986) Coacervation process for preparation of aqueous dispersions of oil-containing microcapsules PAPIERFABRIK AUGUST KOEHLER A.-G. A process and apparatus for preparing an aqueous dispersion of oil-containing microcapsules especially for use in chemical colour reaction papers is described.
- German Offenlegungsschrift 3,504,730 (1985) Heat-sensitive and heat-transfer recording sheet with pressure sensitivity MITSUBISHI PAPER MILLS LTD. T. Matsushita, S. Morishita and M. Sekine. Heat-sensitive and thermal-transfer recording sheets with pressure sensitivity useful for producing multiple copies comprise a base sheet with a heat-sensitive recording layer on one side and microencapsulated colour formers and developers on the other.
- German Offenlegungsschrift 3,520,159 (1985) Photoimaging system containing photosensitive microcapsules MEAD CORP. G. B. Schuster and P. C. Adair. A photoimaging system consisting of photohardenable microcapsules on a support can be used for the production of either positive or negative images.
- German Offenlegungsschrift 3,530,562 (1986) Biocapsules MITSUBISHI PAPER MILLS, LTD. T. Matsushita, S. Morishita, M. Sekine and S. Hiraishi. Heat-sensitive microcapsules containing dry, dead baker's yeast can be used to coat copying papers.
- GERMAN DEMOCRATIC REPUBLIC German D.R. Patentschrift 229,609 (1985) Manufacture of microspherical aluminosilicate VEB CHEMIEKOMBINAT BIWERFELD. R. Haase, W. Kochmann, C. Kain, K. H. Kluger, J. Burkhardt, U. IlIgen, J. Scheve, J. Schulz and U. Apelt. Microspheres of aluminosilicate with improved accessibility of the inner surface for reagents with larger molecules can be used as sorbents, fillers, ion exchangers, catalyst supports or catalysts.
JAPAN
- Japan Kokai Tokkyo Koho 60 110,330 (1985) Preparation of microcapsules containing physiologically active substances such as hemo-globins and enzymes AGENCY OF INDUSTRIAL SCIENCES AND TECHNOLOGY. Microcapsules whose membranes prevent the degradation of the contained haemoglobin or enzymes were prepared.
- Japan Kokai Tokkyo Koho 60 146,848 (1985) Tetraammonium salts for immobilization of enzymes DAIKIN KOGYO CO., LTD. I. Tabuse and T. Sasaki. Prenyltransferase was treated with tetraammonium salt-modified liposomes, which produced the immobilized enzyme.
- Japan Kokai Tokkyo Koho 60 190,227 (1985) Manufacture of microcapsules in polymer solutions DAIO SEISHI K. K.; SHOWA HIGHPOLYMER CO. LTD. M. Kawamura, H. Okamoto, T. Shimada, T. Sato, Y. Doi and M. Awano. Stable microcapsules of amino resins were prepared.
- Japan Kokai Tokkyo Koho 60 190,228 (1985) Manufacture of microcapsules in polymer solutions containing surfactants DAIO SEISHI K. K.; SHOWA HIGHPOLYMER CO. LTD. M. Kawamura, H. Okamoto, T. Shimada, T. Sato, Y. Doi and M. Awano. Microencapsulated nonionic surfactants of sorbital fatty acid esters or their polyoxyethylene ethers were prepared.
- Japan Kokai Tokkyo Koho 60 210,644 (1985) Conveyor belt materials BRIDGESTONE CORP. T. Utsunomiya, Y. Matsumuro, K. Sato, Y. Fukahori and M. Ogawa. Conveyor belt materials were prepared containing microencapsulated parting agents which prevent adhesion of oil sand to the belts.
- Japan Kokai Tokkyo Koho 60 216,839 (1985) Microcapsules MITSUBISHI PAPER MILLS, LTD. T. Kosaka and F. Okumura. Microcapsules were prepared containing hydrophobic substances in the core and suitable for use for carbonless copying paper.
- Japan Kokai Tokkyo Koho 60 219,085 (1985) Recording materials FUJI PHOTO FILM CO., LTD. K. Iwakura, T. Sugiyama and M. Satomura. Microcapsule recording materials useful for heat- and pressure-sensitive recording give high density images and show improved keeping qualities.
- Japan Kokai Tokkyo Koho 60 223,834 (1985) Flotation materials YOKOHAMA RUBBER co., LTD. A. Kamei, K. Shimigu, K. Oki and T. Taniuchi. Flotation materials for submarines were prepared from glass microballoons impregnated with resin.
- Japan Kokai Tokkyo Koho 60 225,167 (1985) Microcapsule toner KONISHIROKU PHOTO INDUSTRY CO., LTD. K. Matsumoto, H. Yamazaki, T. Nagai, S. Suzuki and S. Ikeuchi. A microcapsule toner having a high fluidity and no aggregation was prepared.
- Japan Kokai Tokkyo Koho 60 227,828 (1985) Microcapsule electrostatographic toners KONISHIROKU PHOTO INDUSTRY CO., LTD. K. Matsumoto, H. Yamazaki, T. Nagai, S. Suzuki and S. Ikeuchi. Microencapsulated electrostatographic toners with both high density and mechanical strength were prepared.
- Japan Kokai Tokkyo Koho 60 228,187 (1985) Pressure-sensitive copying sheet YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. M. Maue and A. Shimada. A microcapsule pressure-sensitive copying sheet providing high density images with excellent fastness to decoloration or fading was prepared.
- Japan Kokai Tokyo Koho 60 231,721 (1985) Thermosetting resin microspheres DAINICHISEIKA COLOR AND CHEMICALS MFG CO., LTD. M. Hasegawa, Y. Tsuchiya and K. Higashide. A lubricant consisting of a mixture of thermosetting resin microspheres, urethane resin and solvents was coated on a polyester magnetic tape to produce a tape with low friction.
- Japan Kokai Tokkyo Koho 60 235,161 (1985) Microcapsule toner KONISHIROKU PHOTO INDUSTRY CO., LTD. T. Nagai, S. Suzuki and H. Yamazaki. A microcapsule toner having excellent fixability was prepared.
- Japan Kokai Tokkyo Koho 60 235,163 (1985) Microcapsule toner FUJI PHOTO FILM CO., LTD. T. Mikami and F. Kakimi. A microcapsule toner with an improved antiaggregation property was prepared.
- Japan Kokai Tokkyo Koho 60 239,717 (1985) Electrochromic and electroluminescent displays containing organic clathrates CANON K. K. H. Matsuda, M. Haruta, Y. Hirai, Y. Nishimura, T. Eguchi and T. Nakagiri. The display layer on the substrate is composed of an organic clathrate monomolecular layer or a laminated multimolecular layer.
- Japan Kokai Tokkyo Koho 60 239,742 (1985) Recording media CANON K. K. H. Matsuda, M. Haruta, Y. Hirai, Y. Nishimura, T. Eguchi and T. Nakagiri. The recording media contain carriers on which are formed layers of unimolecular membranes or laminated membranes of unimolecular layers of inclusion complexes.
- Japan Kokai Tokkyo Koho 60 240,490 (1985) No-carbon copying paper MITSUBISHI PAPER MILLS, LTD. M. Ishiguro, F. Okumura and S. Murakami. A pressure-sensitive copying paper especially useful in impact printers contains a microencapsulated leuco dye.
- Japan Kokai Tokkyo Koho 60 240,491 (1985) Heat-sensitive recording materialsFUJI PHOTO FILM CO., LTD. M. Kiritani, T. Usami and T. Tanaka. Heat-sensitive recording materials showing high colour density and low fog have layers carrying microencapsulated diazo compounds and coupling components.
- Japan Kokai Tokkyo Koho 60 241,465 (1985) Cores for thread-wound golf balls SUMITOMO RUBBER INDUSTRIES, LTD. K. Horuichi and S. Nakaide. Golf balls with cores formed by moulding and curing liquid rubber mixtures with microencapsulated fillers have the impact feel and stable flight characteristics of liquid-core balls.
- Japan Kokai Tokkyo Koho 60 242,093 (1985) Multicolor heat-sensitive recording materials FUJI PHOTO FILM CO., LTD. T. Tanaka and T. Usami. The materials consist of microencapsulated colour-forming components and colour developers on a support.
- Japan Kokai Tokkyo Koho 60 244,511 (1985) Reaction-injection molding of plasticsASAHI GLASS CO., LTD. H. Kojima and S. Shibata. A thermally expandable microcapsule containing a blowing agent in a thermoplastic shell is used to reduce mould shrinkage in reaction-injection moulding of plastic.
- Japan Kokai Tokkyo Koho 60 252,347 (1985)Photosensitive imaging sheetsMITSUBISHI PAPER MILLS, LTD. S. Senoo. On one sheet a coloured image is optically recorded. The second sheet produces a hidden image which is developed by pressure transfer of leuco dye microcapsules on to a receptor containing the colour developer.
- Japan Kokai Tokkyo Koho 60 252,634 (1985) Thermoplastic foams HITACHI CABLE, LTD. S. Otani, T. Hatta, T. Sato and S. Kato. The preparation of foams by mixing molten thermoplastics with microencapsulated nucleating agents is described.
- Japan Kokai Tokkyo Koho 60 254,049 (1985)Toner microcapsules KONISHIROKU PHOTO INDUSTRY CO., LTD. K. Matsumoto, H. Yamazaki, T. Nagai, S. Suzuki and S. Ikeuchi. Microcapsules having high fluidity and uniform and stable surface properties were prepared.
- Japan Kokai Tokkyo Koho 60 264,279 (1985) Recording material FUJI PHOTO FILM CO., LTD. S. Ishikawa, M. Imagawa, M. Maeda and F. Shinozaki. A microencapsulated recording material giving a clear black dye image with only one-twentieth of the conventional amount of exposure was prepared.
- Japan Kokai Tokkyo Koho 60 299,980 (1985) Vinyl chloride polymer plastisol sealers AISIN KAKO CO., LTD.; TOYOTA MOTOR CO., LTD. S. Ito, S. Shibata, T. Ikeda and N. Nagata. The preparation of thermally hardenable sealers containing thermally expandable microcapsules is described.
- Japan Kokai Tokkyo Koho 61 00,438 (1986) Decomposition of excess formaldehyde in microcapsule solutions JUJO PAPER MFG CO., LTD. M. Sakamoto and E. Sugyama. The removal by decomposition of excess formaldehyde remaining in microcapsule solutions is described.
- Japan Kokai Tokkyo Koho 61 05,009 (1986) Magnetic diposomes for treatment of tumors MOCHIDA PHARMACEUTICAL CO., LTD. S. Yamaguchi and N. Mochida. Liposomes consisting of Fe304 particles coated with a lipid membrane are readily absorbed by tumours. An external magnetic field creates heat which destroys heat-sensitive tumour cells.
- Japan Kokai Tokkyo Koho 61 05,983 (1986) Diazo thermal recording materials FUJI PHOTO FILM CO., LTD. T. Usami, H. Kamikawa and T. Tanaka. Materials with high storage stability and high thermal sensitivity, fixable by light radiation and easily prepared have the diazo compound in the recording layer contained in plastic microcapsules.
- Japan Kokai Tokkyo Koho 61 05,984 (1986) Diazo thermal recording materials FUJI PHOTO FILM CO., LTD. T. Usami and T. Tanaka. Materials with high storage stability and high thermal sensitivity, fixable by light radiation and easily prepared have a microencapsulated diazo compound in the recording layer.
- Japan Kokai Tokkyo Koho 61 07,845 (1986) Electrostatographic microcapsule toners KONISHIROKU PHOTO INDUSTRY CO., LTD. H. Yamazaki, T. Nagai, S. Suzuki and S. Kawakami. Electrostatographic pressure-fixing type microcapsule toners have improved pressure-fixing characteristics.
- Japan Kokai Tokkyo Koho 61 13,116 (1986) Color indicators for the detection of temperature change in frozen meat MATSUMOTO KOSAN K. K. T. Ono, I. Takahara and M. Nakai. A colour indicator for temperature change is prepared by binding dye-containing microcapsules on to a sheet of paper which is attached to frozen meat. The colour changes with rise in temperature.
- Japan Kokai Tokkyo Koho 61 13,117 (1986) Color indicator for temperature change in cold storage of food MATSUMOTO KOSAN K. K. I. Takahara, T. Ono and M. Nakai. A microencapsulated colour indicator was bound on to a sheet which can be attached to frozen meat and which changes colour at 20°C.
- Japan Kokai Tokkyo Koho 61 15,690 (1986) Stable alkaline phosphatase color test elements KYOWA HAKKO KOGYO CO., LTD. M. Nagashima, M. Azuma and S. Noguchi. A multilayer test element for alkaline phosphatase determination in clinical specimens contains dry microcapsules in the development layer. It is thus very stable and can be kept at 5°C for more than 3 months.
- Japan Kokai Tokkyo Koho 61 15,733 (1986) Microencapsulation of nutritious and medicinal fats and oils MIYOSHI OIL AND FAT CO., LTD. K. Ito. The bitter taste and unpleasant odour of nutritious fats or oils are masked by encapsulation first with gelatin-gum arabic and then with a mixture of coagulable proteins.
- Japan Kokai Tokkyo Koho 61 15,734 (1986) Microcapsules for pressure-sensitive copying paper KANZAKI PAPER MFG CO., LTD. S. Irii, M. Tanaka and T. Shiozaki. Microcapsules were prepared for use in pressure-sensitive copying paper which showed good solvent resistance.
- Japan Kokai Tokkyo Koho 61 22,001 (1986) Biodegradable chloridan microcapsules TOY° JOZO CO., LTD. T. Matsumura and M. Morishita. Microencapsulated chloridan is a controlled-release insecticide readily suspended in water, biodegradable and free from aggregation.
- Japan Kokai Tokkyo Koho 61 22,003 (1986) Microencapsulated diazinone and chlorpyriphos TOY° JOZO CO., LTD. T. Matsumura and M. Morishita. Microencapsulated diazinone and/or chlorpy-riphos is a controlled-release insecticide readily suspended in water, free from aggregation, and effective against cockroaches.
- Japan Kokai Tokkyo Koho 61 22,020 (1986) Glyceryl phosphocholine-containing liposome as an antitumor agent TAKEDA CHEMICAL INDUSTRIES, LTD. S. Nojima and M. Nomura. Antitumour formulations containing phospholipids in liposomes were prepared, and their efficacy against mouse sarcoma-180 was demon-strated in mice.
- Japan Kokai Tokkyo Koho 61 24,519 (1986) Preparation of antitumor liposomes containing glycerol derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. S. Nojima and M. Nomura. The antitumour activity of the liposomes formulated from phospholipids and glycerol derivatives was demonstrated in mice.
- Japan Kokai Tokkyo Koho 61 28,440 (1986) Microcapsules with pH response LION CORP. T. Okabe, M. Takizawa and H. Takahashi. Microcapsules substantially insoluble in alkaline solutions, but soluble in neutral and acidic solutions are useful as additives in alkaline detergent compositions.
- Japan Kokai Tokkyo Koho 61 28,441 (1986) Microcapsules with pH response LION CORP. T. Okabe, M. Takizawa and H. Takahashi. Microcapsules substantially insoluble in alkaline solutions, but soluble in neutral and acidic solutions are useful as additives in detergent compositions.
- Japan Kokai Tokkyo Koho 61 45,250 (1986) Electrophotographic microcapsule toner and preparation TOSHIBA CORP. T. Okuyama, Y. Suzuki, S. Fujiwara and T. Uehara. The preparation of a microcapsule toner without the use of solvents gives a material showing excellent fixability by pressure.
- Japan Kokai Tokkyo Koho 61 47,410 (1986) Microcapsules containing pigments for cosmetics AGENCY OF INDUSTRIAL SCIENCES AND TECHNOLOGY; SUZUKI YUSHI KOGYO K. K. Y. Nakahara and M. Mizuguchi. Microencapsulated pigments for use in cosmetics are stable and homogeneous after long storage.
- Japan Tokkyo Koho 61 01,091 (1986) Soil amendment composition NITTO CHEMICAL INDUSTRY CO., LTD. Y. Kawamura, Y. Miyama and A. Hongo. A soil amendment which produces improved germination rate and root growth in a seedling bed contains partially water-soluble urea resin hollow microparticles.
PCT
- PCT Application 85 04,326 (1985) Polymeric liposomes as stable gas carriers BIOCOMPATIBLES LTD. D. Chapman and J. A. Hayward. Liposomes containing haemoglobin which could reversibly bond with oxygen, nitrogen and carbon dioxide under physiological conditions may be used as erythrocyte substitutes.
- PCT Application 85 04,841 (1985) Pressure-sensitive copying paper MITSUBISHI PAPER MILLS LTD. T. Kosaka, M. Ishiguro and H. Senoh. The copying paper with excellent colour-forming properties, no smudges and long-term storage stability consists of a microencapsulated top sheet and a coated bottom sheet.
- PCT Application 85 05,113 (1985) Fiber-reinforced syntactic foam composites HUGHES AIRCRAFT CO. P. S. DuPont, J. E. Freeman, R. E. Ritter, A. Whittmann and S. L. Oldham. The composites, prepared from a heat-curable thermosetting resin, hollow microspheres and fibres are useful in spacecraft applications, e.g. as antennae and waveguides.
- PCT Application 86 01,102 (1986) Encapsulation of antineoplastic agents in liposomes LIPOSOME CO., INC. M. B. Bally, P. R. Cullis, M. J. Hope, T. D. Madden and L. D. Mayer. The preparation is described of liposomes with nearly 100 per cent trapping efficiency.
- PCT Application 86 01,103 (1986) Dehydrated liposomes LIPOSOME CO., INC. A. S. Janoff, P. R. Cullis, M. B. Bally, M. W. Fountain, R. S. Ginsberg, M. J. Hope, T. D. Madden, H. P. Schieren and R. L. Jablonski. Liposomes dehydrated in the presence of sugars are stable during dehydration, storage and rehydration.
- PCT Application 86 01,112 (1986) Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging FOX CHASE CANCER CENTER. T. Brown. For imaging tumour tissue, ferromagnetic microparticles couple to monoclonal antibodies, which bind to the tumour via tumour antigens.
- PCT Application 86 01,404 (1986) Using nutrient-containing liposomes in hyperalimentation A. J. Mixson. The nutrient fluid contains liposomes comprising phosphatidylcholine encapsulating oligosaccharide, together with amino acids and glucose.
- PCT Application 86 01,714 (1986) Liposomal sustained-release aerosol delivery system RICER LABORATORIES, INC. B. Carman-Meakin, I. W. Kellaway End S. J. Farr. Drug-containing liposomes are prepared by the use of a phospholipid-containing aerosol.
UK
- UK Patent Application 2,158,958 (1985) Heat-sensitive recording material FUJI PHOTO FILM CO., urn. T. Usami, T. Tanaka and S. Yoshida. A heat-sensitive recording material for high-speed printers consists of a microencapsulated colourless dye precursor, a colour developer and a binder.
USA
- US Patent 4,547,490 (1985) Synthetic whole blood NEOMED CORP. C. S. Ecanow and B. Ecanow. Synthetic whole blood useful as a substitute for natural blood is composed of a two-phase coacervate, and a composition useful as a substitute for erythrocytes consists of the coacervate phase of the two-phase system.
- US Patent 4,551,288 (1985) Liposome drug delivery systems SANDOZ INC. L. A. Kelly. A liposome drug delivery system uses a gel filtration column such that the non-liposomal effluent may be recycled for continuous operation.
- US Patent 4,562,137 (1985) Photosensitive material employing an encapsulated radiation-sensitive composition MEAD CORP. F. W. Sanders. A photo-sensitive material containing an encapsulated radiation-sensitive composition is useful for copying images from microfilm, a recorder-printer or a cathode-ray tube.
- US Patent 4,565,696 (1986) Production of immunogens by antigen conjugation to liposomes UNIVERSITY OF CALIFORNIA. T. D. Heath, P. Shek and D. Papahadjopoulos. Immunogens covalently linked to liposomes provide a method for potentiating an immune response.
- US Patent 4,567,034 (1986) Esters of diatrizoic acid as X-ray contrast agents SQUIBB, E. R. AND SONS, INC. J. Charles and M. Robinson. Esters of diatrizoic acid are used with a carrier, such as a liposome, in X-ray contrast media.
- US Patent 4,568,559 (1986) Composite core coated microparticles BIOTEK INC. E. S. Nuwayser and W. A. Nucefora. Coated microparticles of hydrophobic drugs were prepared which in vitro and in vivo testing showed controlled release of up to 200 days.
- US Patent 4,571,332 (1986) Iodine-125 and iodine-131 labeled phospholipids LITTON BIONETICS, INC. A. J. Schroit and I. J. Fidler. Radioiodine-labelled phospholipids incorporated into vesicles are useful for the determination of the homing properties of particular liposomes.
- US Patent Application 714,711 (1985) Magnetically localizable polymerized lipid vesicles containing pharmaceuticals, and a method of releasing them UNITED STATES DEPT OF THE NAVY. E. L. Chang. Liposomes containing therapeutic agents and ferromagnetic particles can be injected and then targeted by an external magnetic field.