Patent Briefing

PATENT BRIEFING

EUROPE

• European Patent Application 152,083 (1985) Powder of microcapsules KANZAKI PAPER MFG. CO., LTD. S. Shioi, G. Matoba and M. Miyake. A dried powder of chiefly single core microcapsules of hydrophobic materials was prepared.
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• European Patent Application 152,102 (1985) Composite laminate film KUREHA CHEMICAL INDUSTRY CO. LTD. Y. Okada and Y. Igarashi. Multilayer films containing microen-capsulated hardening accelerators have good transparency and short manufacturing cycles.
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• European Patent Application 152,209 (1985) Storage stable one-pack compositions LOCTITE (IRELAND). F. R. Martin, S. M. Grant and J. Sheenan. A one-pack curable composition with extended shelf-life is prepared by encapsulating one component in resin. Rapid curing is induced by heating to the melting point of the resin.
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• European Patent Application 152,285 (1985) Process and apparatus for the production and collection of microcapsules
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• SOUTHWEST RESEARCH INSTITUTE. W. W. Harlowe, L. M. Adams and M. C. Marshall. An apparatus is described for producing liquid-filled microcapsules with insignificant breakage during manufacture.
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• European Patent Application 152,379 (1985) Pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY A.-G. R. Muntwyler and H. Hauser. Aqueous pharmaceutical dispersions of unilamellar liposomes containing an amphipathic drug and a phospholipid were prepared.
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• European Patent Application 154,055 (1985) Accelerating the breakdown of phenolic resin bonded cores KUSAKA RARE METAL PRODUCTS CO., LTD. 0. Madono. The breakdown of phenolic resin bonded cores, especially in aluminium casting, is accelerated by the addition of a basic salt of an alkali metal, microencapsulated in resin, to phenolic resin-coated sand.
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• European Patent Application 158,449 (1985) Microcapsules and microencapsulation STAUFFER CHEMICAL co. H. B. Scher and M. Rodson. A substantially water insoluble liquid material was microencapsulated within a porous shell thereby effecting a slow release rate.
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• European Patent Application 160,266 (1985) Liposome composition TERUMO CORP. J. Aoyagi, Y. Yamamoto, T. Akaike and Y. Nozaki. Liposomes showing slow sustained drug release in simulated gastric juice were prepared.
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FR GERMANY

• German Offenlegungsschrift 3,336,583 (1985) Product for diagnosis and therapy of malignant tumors U. Ehrenfeld. Liposomes containing dyes and/or radioactive tracers can be used for diagnosis md- therapy.
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• German Offenlegungsschrift 3,407,686 (1985) Analytical device for gases by an indicator strip DRAEGERWERK A.-G. J. MarcoII and B. Westrup. The gas measuring device contains indicator strips impregnated with three different microencapsulated chemical reagents which change colour when the gas passes through. The microcapsules are pressed for activation.
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• German Offenlegungsschrift 3,412,793 (1985) Liposomes with inhalable allergens for the treatment of allergies
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• BASOTHERM G.m.b.H. H. E. Kompa. Inhalable allergens in liposomes are taken up preferentially by the reticuloendothelial cells involved in the immune response thus giving enhanced hyposensitization. The liposomes can also be administered orally.
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• German Offenlegungsschrift 3,502,748 (1985) Encapsulated electrophotographic toner CANON K. K. M. Yamazaki, K. Wakamiya, T. Matsumoto, I. Ohsaki, T. Nakahara and H. Ushiyama. Encapsulated electrophotographic toners with good fixing characteristics consist of a thin shell and a core containing a long chain organic binder with an ester of a high alcohol and a higher carboxylic acid.
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• German Offenlegungsschrift 3,512,926 (1985) Use of interleukin-2 liposomes in therapy SANDOZ-PATENT G.m.b.H. T. Kissel, J. Reinhardt and H. Schrank. Liposomes containing 50 per cent interleukin-2 showed unaltered biological activity.
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GERMAN DEMOCRATIC REPUBLIC

• German D.R. Patentschrift 218,471 (1985) Microfine polyolefin powder and polyolefin wax powder C. Bischof, H. Herma and M. Raetzsch. The powders were prepared in high yield as nonagglomerating spheres of which 96 per cent had diameter 30 pm.
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JAPAN

• Japan Kokai Tokkyo Koho 60 78,634 (1985) Microencapsulation of pharmaceuticals with chitosan ICHIMARU FARUKOSU K. K. Pharmaceuticals, such as theophylline and aspirin, are granulated and treated with a solution of chitosan to form microcapsules.
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• Japan Kokai Tokkyo Koho 60 87,225 (1985) Preparation of accelerators of fibrin formation UNITIKA LTD. Cellulose microcapsules treated with thrombin and blood coagulation factor XIII produce materials that accelerate fibrin formation when applied to wounds.
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• Japan Kokai Tokkyo Koho 60 92,211 (1985) Sustained-release antitumor substance preparations UNITIKA LTD. Antitumor substances and blood coagulation agents immobilized on cellulose microcapsules produce sustained-release preparations.
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• Japan Kokai Tokkyo Koho 60 103,359 (1985) Microcapsule toners CANON K. K. Microcapsule toners having soft cores with relatively high water (or other solvent) content which helps toner fixability were prepared.
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• Japan Kokai Tokkyo Koho 60 107,383 (1985) Pressure-sensitive recording sheet FUJI PHOTO FILM CO. LTD. A pressure-sensitive recording sheet showing excellent lightfastness contains a microencapsulated colourless dye in a colourant layer.
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• Japan Kokai Tokkyo Koho 60 110,257 (1985) Microencapsulated oils for noodle quality improvement KIKUSUI KAGAKU KOGYO CO., LTD. Noodles having texture and flavour similar to the high quality somen noodles which are produced by year-long ageing are prepared from dough containing microencapsulated oils.
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• Japan Kokai Tokkyo Koho 60 115,497 (1985) Composite materials of transparent substance with magnetic or dielectric substance S. Kawashima. Composite materials useful as red and blue display panels contain freely rotatable particles of iron having blue N poles and red S poles. The iron particles were microencapsulated and adhered to a polyethylene film support.
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• Japan Kokai Tokkyo Koho 60 117,254 (1985) Toners for electrostatic image development CANON K. K. Microencapsulated toners giving high resolution images without fog and with good durability, flow characteristics and fixability were prepared.
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• Japan Kokai Tokkyo Koho 60 120,366 (1985) Encapsulated electrophotographic toners FUJI PHOTO FILM CO., LTD. Encapsulated toners showing good powder properties and good fixing performance, even after long storage, consist of a core containing a coloured material and a binder and a shell of one or more resins.
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• Japan Kokai Tokkyo Koho 60 120,811 (1985) Soft gelatin microcapsules for oral or pharyngeal application R. P. SEALER K. K. Soft microcapsules that adhere to the mucous membranes for the prolonged release of the active ingredients were prepared.
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• Japan Kokai Tokkyo Koho 60 121,456 (1985) Microcapsulated toners CANON K.K. Microcapsule toners especially useful for developing electrostatic images and with improved durability, pressure-fixing performance and stable positive-charging properties were prepared.
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• Japan Kokai Tokkyo Koho 60 131,462 (1985) Microparticles for the determination of cell functions TORAY INDUSTRIES INC. The determination of cell functions is based on changes in intensity of the fluorescence of microparticles coated with fluorescent substances in response to cellular enzymic reactions, phagocytosis or membrane mobility.
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• Japan Kokai Tokkyo Koho 60 139,331 (1985) Microencapsulation of solid impact-sensitive organic peroxide SANKEN KAKO CO. LTD. H. Imamura. Impact-sensitive solid organic peroxides, useful as catalysts in polymerization and hardening reactions, are stabilized by microencapsulation in unsaturated polyester resin.
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• Japan Kokai Tokkyo Koho 60 139,332 (1985) Microencapsulation of solid impact-sensitive organic peroxide SANKEN KAKO CO., LTD. H. Imamura. A solid impact-sensitive organic peroxide is stabilized by being microencapsulated twice in an unsaturated polyester resin.
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• Japan Kokai Tokkyo Koho 60 147,746 (1985) Microcapsule toners CANON K. K. K. Wakamiya, M. Yamazaki, T. Matsumoto, I. Osaki, T. Nakahara and N. Ushiyama. A microcapsule toner was prepared which gives high density images even from low potential electrostatic latent images.
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• Japan Kokai Tokkyo Koho 60 147,748 (1985) Microcapsule toners CANON K. K. K. Wakamiya, M. Yamazaki, T. Matsumoto, I. Osaki, T. Nakahara and N. Ushiyama. A microcapsule electrostatographic toner having high mechanical strength prevents adhesion to sleeves and rollers and gives high density images without greasing.
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• Japan Kokai Tokkyo Koho 60 149,642 (1985) Cellular polymer sheets ACHILLES CORP. Y. Sogabe, K. Uchida and K. Harada. A thin leather substitute with supple handle and useful for garments is prepared by forming sheets from microencapsulated compositions.
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• Japan Kokai Tokkyo Koho 60 151,648 (1985) Electrostatographic magnetic toner and preparation Riccm CO., LTD. A. Suzuki and M. Shimada. A microencapsulated toner with high fluidity and uniform particle diameters consists of a core with a coating of a colourant and fine polymer particles and overcoated with one or more layers containing polymer particles, and optionally, a colourant.
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• Japan Kokai Tokkyo Koho 60 151,652 (1985) Electrostatographic magnetic toner RICOH CO., LTD. A. Suzuki and M. Shimada. A microencapsulated toner with high fluidity and having uniform particle diameters consists of a core containing a magnetic powder or colourant and a coating containing a magnetic powder or colourant and fine polymer particles.
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• Japan Kokai Tokkyo Koho 60 152,410 (1985) Preparation of drug-liposome inclusion compounds POLA CHEMICAL INDUSTRIES, INC. H. Komatsu. Pharmaceutical-liposome inclusion compounds in transdermal pharamceuticals release the drugs into the skin rapidly.
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• Japan Kokai Tokkyo Koho 60 152,414 (1985) Poultices containing drugs stabilized in liposomes POLA CHEMICAL INDUSTRIES, INC. H. Komatsu. A poultice was prepared containing a drug stabilized in a liposome in the base material. The drug was slowly released on to the skin.
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• Japan Kokai Tokkyo Koho 60 155,109 (1985) Liposomes containing, pharmaceuticals TERUMO CORP. H. Haruo, T. Maruyama and N. Saito. Stabilization and sustained release of drugs was effected by incorporation in liposomes.
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• Japan Kokai Tokkyo Koho 60 155,119 (1985) Liposomes containing fatty acid-bound amino acids, peptides and glycosides for induction of antibodies TOBISHI PHARMACEUTICAL CO., LTD. I. Yamashina. Amino acids and low molecular weight peptides and glycosides become antigenic when incorporated with fatty acids into liposomes which produce antibodies for use in immunoassays.
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• Japan Kokai Tokkyo Koho 60 159,652 (1985) Reagents for immunochemical analysis TOSHIBA CORP. Y. Ishimori, N. Yoshio, M. Notsuke and M. Koyama. A second antibody immobilized on microcapsules or liposomes containing labelling substances forms a reagent for immunochemical analysis.
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• Japan Kokai Tokkyo Koho 60 160,840 (1985) Health food microcapsules containing unsaturated fatty acids for the control of cholesterol level in blood MIYOSHI 011, AND FAT CO., LTD. K. Ito, M. Kawashima, Y. Sano and M. Sonehara. The preparation of microencapsulated polyunsaturated fatty acids derived from deodorized sardine oil is described.
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• Japan Kokai Tokkyo Koho 60 161,920 (1985) Feed containing plant growth hormones for silkworms M. Kamata. Animal growth promoting agents, stable at different temperatures and resistant to enzymes, are prepared b> encapsulating plant goiwth hormones with sterols in liposomes.
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• Japan Kokai Tokkyo Koho 60 175,538 (1985) Microcapsules JAPAN OXYGEN CO., LTD. M. Koishi, T. Sada, M. Taniguchi, T. Kimijima and Y. Satomi. Compounds which undergo chemical or physical reactions at room temperature can be encapsulated in high yield by preparing the microcapsules at a temperature below room temperature.
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• Japan Kokai Tokkyo Koho 60 179,132 (1985) Hollow microspheres MITSUBISHI CHEMICAL INDUSTRIES CO., LTD. H. Yanagawa and K. Kojima. Hollow microspheres of amino acids with NH2, OH or COOH in the side chain are heat resistant and useful as carriers, permeating membranes and microcapsules.
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• Japan Kokai Tokkyo Koho 60 179,500 (1985) Density-controlled microcapsules cr (mox ro. Microencapsulated coloring or whitening agents are dispersed in bleaching solutions.
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• Japan Kokai Tokkyo Koho 60 184,004 (1985) Cosmetics containing hollow polymer spheres POLA CHEMICAL INDUSTRIES, INC. K. I yanagi, M. Horino, M. Hanbayashi and N. Munehiro. Cosmetics containing hollow polymer spheres spread easily on the skin, are long-lastand have enhancedtransparency.
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• Japan Kokai Tokkyo Koho 60 185,716 (1985) Liposomes as oil-in-water-type emulsions containing carbamoy1-5-fluorouracil for injection MITSUI PHARMACEUTICALS, INC. H. Sezaki and M. Hashida. The liposome emulsions prepared for use in cancer chemotherapy had good biomembrane permeability and tissue affinity.
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• Japan Tokkyo Koho 60 32,496 (1985) Microencapsulation and tightly sealing of microcapsules PENTEL CO., LTD. M. Iwata and Y. Ko. Tightly sealed microcapsules which showed no sign of leakage after 10 days were manufactured.
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• Japan Tokkyo Koho 60 34,473 (1985) Pressure-sensitive copying paper KANZAKI PAPER MEG. CO., LTD. S. Shioi, T. Tada and J. Kono. Pressure-sensitive copying microcapsule sheets gave a copying paper having excellent pressure- and abrasion-blemish resistance.
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ROMANIA

• Romanian Patent 85,310 (1984) Microencapsulation of materials immiscible with water, such as herbicides MONSANTO co. G. B. Beestman and J. M. Deming. Materials immiscible with water, mostly pesticides, are microencapsulated in polyurea.
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USA

• US Patent 4,530,946 (1985) Resinous emulsion comprising microparticles for coating use NIPPON PAINT CO., LTD. K. Kanda, K. Ishii, K. Kida, S. Ishikura and R. Mizuguchi. Microencapsulated emulsions of cross-linked polymers stabilized with resins are useful as coatings.
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• US Patent 4,532,217 (1985) Biological uses of shift reagents for the nuclear magnetic resonance of physiological metal cations STATE UNIVERSITY OF NEW YORK, RESEARCH FOUNDATION. C. S. Springer Jnr, M. M. Pike, J. A. Balschi, D. M. Yarmush and S. C. K. Chu. Anionic Dy and Tm chelates causes concentration-dependent shift in the NMR spectrum of alkali and alkaline earth metal anions and can be used to measure transport of the ions through membranes.
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• US Patent 4,536,524 (1985) Microencapsulated epoxy adhesives CAPSULATED SYSTEMS INC. R. L. Hart, D. E. Work and C. E. Davis. Microencapsulated epoxy adhesives for threaded fasteners consist of hydrophobic curing agents in epoxy resin capsules.
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• US Patent 4,542,019 (1985) Antacid compositions J. Lezdey. A magnesium aluminate hydrate-type active ingredient incorporated into a phospholipid liposome provides a controlled-release antacid.
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