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Journal of Microencapsulation
Micro and Nano Carriers
Volume 6, 1989 - Issue 2
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Research Article

Liposomes as Cyclosporin a Carriers: Positively Charged Lecithin-Cholesterol Liposomes Associated with Cyclosporin a do not Inhibit Biosynthesis of Mitochondrial Poly Glycerophosphates and Microsomal Phosphatidylinositol

Lidija Stuhne-Sekalec The Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, M5G 1L5, Canada
&
Nikola Z. Stanacev The Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, M5G 1L5, Canada
Pages 177-182 | Received 14 Mar 1988, Accepted 30 Mar 1988, Published online: 27 Sep 2008

References

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  • Davidson J. B., Stanacev N. Z. Biosynthesis of phosphatidic acid in mitochondria and microsomes via the acylation of sn-glycero-3-phosphate. Canadian Journal of Biochemistry 1972; 50: 936–948
  • Drug Carriers in Biology and Medicine, G. Gregoriadis. Academic Press, New York 1979
  • Kiyasu J. Y., Pieringer R. A., Paulus H., Kennedy E. P. The biosynthesis of phosphatidylglycerol. Journal of Biological Chemistry 1963; 238: 2293–2298
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  • Shek P. N., Yung B. Y. K., Stanacev N. Z. Comparison between multilamellar and unilamellar liposomes in enhancing antibody formation. Immunology 1983; 49: 37–44
  • Stuhne-Sekalec L., Chudzik J., Stanacev N. Z. Encapsulation of cyclosporine by phosphatidylinositol-cholesterol liposomes. Transplantation 1986; 41: 659–660
  • Stuhne-Sekalec L., Stanacev N. Z. Evidence that the effect of soya bean phosphatidylinositol-cholesterol-cyclosporin liposomes on the biosynthesis of acidic phospholipids in isolated subcellular membranes from rat liver and heart is attributable to the soya bean phosphatidylinositol-cholesterol liposomes. Journal of Microencapsulation 1988a; 5: 47–58
  • Stuhne-Sekalec L., Stanacev N. Z. Interaction of cyclosporin A with 1,2-dimyristoyl-sn-3-phosphatidylcholine unilamellar vesicles studied by ESR. Chemistry and Physics of Lipids 1988b, in press
  • Tomlinson E. Theory and practice of site-specific drug delivery. Advanced Drug Delivery Reviews 1987; 1: 87–198

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